Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 1.6 7.2e+02 1.3 0.1 25 46 62 83 49 89 0.79

2 10 9.1 4.1e+03 -1.2 0.0 23 44 88 109 84 112 0.77

3 10 0.028 12 6.9 0.1 21 46 114 139 111 145 0.84

4 10 0.0067 3 8.9 0.1 21 44 142 165 138 169 0.78

5 10 0.001 0.46 11.5 0.3 21 46 170 195 162 201 0.86

6 10 1.4 6.4e+02 1.4 0.1 21 45 198 222 194 231 0.70

7 10 1.9 8.5e+02 1.0 0.1 21 44 226 249 222 253 0.68

8 10 0.00011 0.05 14.6 0.4 21 47 254 280 246 285 0.82

9 10 0.014 6.5 7.8 0.0 21 45 282 306 279 310 0.89

10 10 0.0019 0.84 10.7 0.1 21 45 310 334 306 337 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	1.6	7.2e+02	1.3	0.1	25	46	62	83	49	89	0.79
2	10	9.1	4.1e+03	-1.2	0.0	23	44	88	109	84	112	0.77
3	10	0.028	12	6.9	0.1	21	46	114	139	111	145	0.84
4	10	0.0067	3	8.9	0.1	21	44	142	165	138	169	0.78
5	10	0.001	0.46	11.5	0.3	21	46	170	195	162	201	0.86
6	10	1.4	6.4e+02	1.4	0.1	21	45	198	222	194	231	0.70
7	10	1.9	8.5e+02	1.0	0.1	21	44	226	249	222	253	0.68
8	10	0.00011	0.05	14.6	0.4	21	47	254	280	246	285	0.82
9	10	0.014	6.5	7.8	0.0	21	45	282	306	279	310	0.89
10	10	0.0019	0.84	10.7	0.1	21	45	310	334	306	337	0.89

Coding Sequence: ATGGAACGCATCGACGAAGTATCGGAACCTCTCAATAATTCTAGTAGCTGTGAAATTAAGGTCGAAGATGAGAAGTTTAATATAGAAGATTTACATCACTCGATAGACATCAAAGACGAGATCGAGAGCGATGCAGAACAACTAGCACTGGAGAAACCCGTAAGAAAAACTAAAAACTTAAATTTTATATGTCAGTTTTGTGATTATAAATGTGAACAGAAATCAAATTTAAAAATACATTTAAAAATTCACGTAGGCGAAAAACGTTTTGCTTGTGAGATTTGTGATTATAAATGTGCAAAAAAAGGCGATTTGAAAAAACATTTAATAACTCACACAGGCGAAAAACCTTTTGTTTGTGAGATTTGTGACTATAAATGTGTACAAAGAACAAATTTAAAAATACATTTGAGAACTCACACAGGTGAAAAACCTTTTACTTGTGATATTTGCTACTATAAATTTTCACTAAGATCACATTTAAAAACACATTTAAGAACTCACACAGGTGAAAAACCTTTTGTTTGTGTGATCTGTGACTTTAAATGTGCACAAAGAGCAAATTTAAAAAGACATTTAAGAACGCACACAGGCGAGAAACCTTTTTCGTGTGAGATTTGTGACTATAAATGTGCGCACAGAGAAAGTTTAAAAAGTCATTTCAAGACTCACACAGGCGAGAAACCTTTTGTTTGTGTGATTTGTGACTATCGATTTGTAACAAGAGAACATTTAAAAACACATTTGAGAACTCACACAGGTGAAAAACCTTTTACTTGTGATATTTGCTACTATAAATGTTCACGAAGATCACATTTAAAAAGACATTTAAAAACTCACACAGGTGAAAAACCTTTTACTTGTGAGATTTGCGACTATAAATGTGCAGAAAGAGGAGATTTAAAAAGACATTTAAAAACTCACACAGGTGAAAAACCCTTTACCTGTGAGATTTGTGACTATAAATGTGCACACAAAGTAAATTTAAAAAGACATTTAAGAACTCACAGGCGATAA
Protein Sequence: MERIDEVSEPLNNSSSCEIKVEDEKFNIEDLHHSIDIKDEIESDAEQLALEKPVRKTKNLNFICQFCDYKCEQKSNLKIHLKIHVGEKRFACEICDYKCAKKGDLKKHLITHTGEKPFVCEICDYKCVQRTNLKIHLRTHTGEKPFTCDICYYKFSLRSHLKTHLRTHTGEKPFVCVICDFKCAQRANLKRHLRTHTGEKPFSCEICDYKCAHRESLKSHFKTHTGEKPFVCVICDYRFVTREHLKTHLRTHTGEKPFTCDICYYKCSRRSHLKRHLKTHTGEKPFTCEICDYKCAERGDLKRHLKTHTGEKPFTCEICDYKCAHKVNLKRHLRTHRR

Sequence clustering based on sequence similarity using MMseqs2