Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.001 0.45 11.5 0.0 21 48 85 112 77 118 0.90

2 6 0.048 22 6.1 0.1 20 47 141 168 133 175 0.69

3 6 0.73 3.3e+02 2.4 0.1 22 52 171 201 166 203 0.78

4 6 4.9e-05 0.022 15.7 0.0 21 52 226 257 217 259 0.84

5 6 0.37 1.7e+02 3.3 0.0 21 43 254 276 251 283 0.77

6 6 0.00058 0.26 12.3 0.1 21 45 282 306 278 309 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.001	0.45	11.5	0.0	21	48	85	112	77	118	0.90
2	6	0.048	22	6.1	0.1	20	47	141	168	133	175	0.69
3	6	0.73	3.3e+02	2.4	0.1	22	52	171	201	166	203	0.78
4	6	4.9e-05	0.022	15.7	0.0	21	52	226	257	217	259	0.84
5	6	0.37	1.7e+02	3.3	0.0	21	43	254	276	251	283	0.77
6	6	0.00058	0.26	12.3	0.1	21	45	282	306	278	309	0.90

Coding Sequence: ATGGATAAAGAAGATATGTTTGAAACAGTCCAAATATGTGGAAGTCCAAAAGTCGAAATTAAACAAGAAGAGGTTGAATTTGACTCTGAAAATTTGCATCACACTTTTGATATAAAAGATGAGCTCTCTTTTCCGGAAACCAAACTGGTTGACGAAATTGTAGTACAAATTATAAAGCATTTCGAATGCGAAATTTGTGACTATAAAAGTGTCCATCACTACAGATTAAAGGATCACTTAAAAACACACACTGGTGAGAAACCATTTAATTGTGAAATATGCAATCAGAAATTCACCCAAAGCGGAACTTTAACGCGGCATGTTAAAACACAGCATTCTGACGAAAAACCGTTTAGGTGTGATTTTTGTGAGTATAAAAGTAGTCGTAAGAGTGATTTAAGTGATCATGTGAGAAGTCACACTGGTGAGAAACCATTTGAATGTACTATTTGTTACCATAAAAGTGCACGAAAAGGTGACTTTAGTGCTCATTTAAAAACTCACACCAATGATAAACCGTATGTGTGTGAAATTTGTGACTACAGTAGCGCACATAAGTATAGATTAAAGGATCACTTAAAAATTCACTCTGCGGTGAAACCATTCGGATGTACAAAGTGTGACTTCAAATCTGCTTTTAAGAAAATTTTGAAAGAACACTTAAGGACTCATTCAGGTGAAAAGCCGTTTACATGTGAGATATGTAATCAGAAATTTAAGCAAGTTGGAAGTTTGAAACGGCATATTAAAATTCATACTGGAGAAAAACCATTTGTTTGTGATATTTGTGATTATAAGAGTATTCGTAAGCATGATTTGCTTGATCATTTAAAAACCCATACTGGGGAGAAACCGTTTACTTGTGAGTTTTGTTACTATACAAGTGCATTAAGGAGTAATTTGAAAAGACATTTAAGGACCCACGCTGACTAA
Protein Sequence: MDKEDMFETVQICGSPKVEIKQEEVEFDSENLHHTFDIKDELSFPETKLVDEIVVQIIKHFECEICDYKSVHHYRLKDHLKTHTGEKPFNCEICNQKFTQSGTLTRHVKTQHSDEKPFRCDFCEYKSSRKSDLSDHVRSHTGEKPFECTICYHKSARKGDFSAHLKTHTNDKPYVCEICDYSSAHKYRLKDHLKIHSAVKPFGCTKCDFKSAFKKILKEHLRTHSGEKPFTCEICNQKFKQVGSLKRHIKIHTGEKPFVCDICDYKSIRKHDLLDHLKTHTGEKPFTCEFCYYTSALRSNLKRHLRTHAD

Sequence clustering based on sequence similarity using MMseqs2