Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 9.3e-42 2.9e-38 131.7 0.1 1 88 78 164 78 164 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	9.3e-42	2.9e-38	131.7	0.1	1	88	78	164	78	164	0.98

Coding Sequence: ATGCAAAGTGGTAATGCTAACATGACAATATCTCCAGTTTCGAGCTTCAACATATCTGGGGGATCTGCAAATGCTTTAACAGGAGGAAATAGCAATAACTCTCACACTTCGGTGGAATCGACCGACGAACCGGTACGTGCAGCCAGCACCAGCTCCAGTCATTCGCCGCAACCCCAACCATCGTCCTCAACGGCGTCATCAACTACTAATAGCAGTTCAAACAGCAGCCAAAGCAAACCGCCATACTCGTACGTAGCCCTTATAGCAATGGCGATACAGTCGTCCCACTTAAAAAGAGCGACCTTGTCAGAAATTTACCAATACATCACCTCCAAGTTTCCATATTTCGAACGTAACAAGAAGGGCTGGCAGAACTCCATTAGACACAACTTGAGCTTGAACGAGTGTTTTGTCAAAGTCCCTAGGGAAGGAGGTGGTGAACGAAAAGGCAACTACTGGACGCTGGACCCTCAATACGAAGACATGTTCGAAAATGGCAACTACAGGAGGCGAAGGCGAATGAAGAGACCATATCGTTCTGCTCAGCCGTACCCCAAAGCGTTCTTCACAGAGACTCTAGGGCAACACGGTCTTCCTTTGGCAAGGAATATTTTCACTCCTCCCACGTATCCTCCCCCATACTCTCGTTACGAAACCACTTGGCTGGGGCAGTCCCAGCTTGCATCGTACACGAGTTGCAATTCTGGAGGTTATCCTCAACAAGGCTACCCCTCACCGGCAGCCTTTAGCCCTTGTAGCGTGAGACAAGAAGCAGCGGCGCGGTACCCGCCTTACTGGCCACCTGAGAGTGAGTACTCCCCCGGTCCCCACAATTCGCCCCCTGCTGATCCCCAGCTCCTGTTGCAGTGGTGA
Protein Sequence: MQSGNANMTISPVSSFNISGGSANALTGGNSNNSHTSVESTDEPVRAASTSSSHSPQPQPSSSTASSTTNSSSNSSQSKPPYSYVALIAMAIQSSHLKRATLSEIYQYITSKFPYFERNKKGWQNSIRHNLSLNECFVKVPREGGGERKGNYWTLDPQYEDMFENGNYRRRRRMKRPYRSAQPYPKAFFTETLGQHGLPLARNIFTPPTYPPPYSRYETTWLGQSQLASYTSCNSGGYPQQGYPSPAAFSPCSVRQEAAARYPPYWPPESEYSPGPHNSPPADPQLLLQW

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01014053; iTF_00110345; iTF_00165865; iTF_01121385; iTF_01295785; iTF_01283115; iTF_01329591; iTF_00327663; iTF_00328960; iTF_01162897; iTF_01277489; iTF_01310131; iTF_00395060; iTF_00755255; iTF_01368824; iTF_00885707;
90% Identity: iTF_01295785; iTF_01368824; iTF_00885707;
80% Identity: -