Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0054 23 6.1 0.1 20 46 109 135 92 137 0.85

2 7 0.0051 22 6.2 0.4 21 48 138 165 134 168 0.86

3 7 0.26 1.1e+03 0.7 0.1 18 44 164 190 158 194 0.74

4 7 0.042 1.8e+02 3.3 0.0 22 49 196 223 188 226 0.84

5 7 0.0071 30 5.7 0.1 21 45 223 247 221 251 0.90

6 7 0.0017 7.1 7.7 0.1 21 45 251 275 247 278 0.89

7 7 0.001 4.4 8.4 0.4 21 46 279 304 274 307 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0054	23	6.1	0.1	20	46	109	135	92	137	0.85
2	7	0.0051	22	6.2	0.4	21	48	138	165	134	168	0.86
3	7	0.26	1.1e+03	0.7	0.1	18	44	164	190	158	194	0.74
4	7	0.042	1.8e+02	3.3	0.0	22	49	196	223	188	226	0.84
5	7	0.0071	30	5.7	0.1	21	45	223	247	221	251	0.90
6	7	0.0017	7.1	7.7	0.1	21	45	251	275	247	278	0.89
7	7	0.001	4.4	8.4	0.4	21	46	279	304	274	307	0.88

Coding Sequence: ATGGAAAACTCATCTGAAAAAACTGAAGAACATTTTGTTGTTAACATCTCTCCAGAAGATGTTAAAGTGGAACTCAGTTGTGAACCTGATCTTCATGATTATAACTCGGATACAGTTTCGTTTAGTGGTGTAATGTATAATTCTGAAATCAGCTGTGCACATTCCCAAGAATATTCCTGCTCCGTATACAATAATACGGTTCAAGAAAACTCCGAAGCTCACACAACACCAGGAAAAACTGCAGAGGACGAAATATTTCCTTGCACATATTGTGAGAAGACCTTCAGCAAAAAATTCGGATTAGAGCGACACCTACGTACTCATACTAAAGAAAagccattttcttgtacaatatGTGGTAAAAGTTTCTCAGATTGTGGAAGCATGAAGCGACATTTAAGGATCCACACTGGAGAACAGCCCCACTCTTGCTCAATTTGTGAGATGAAGTTCAACAGGCTTTACAATTTGACACTTCACATGAGAACAAGTCATTCGAAGGAAAGGCCTTTTGCATGCAcattttgtgaaaaaaaattcGCAGAAAATTCAAGGCTTCAAGAACACTTAAGAACCCATACTGGAGACACACCTTACCTGTGTACATTTTGCCAGAAGGGCATGAAAAGCAGTACAGATTTGAAAATTCACCTAAGGATTCATACCGGAGAGAAACCGTTCCTTTGTACCATTTGCGAGAAAAGATTTTCCCAGAGCCAACATTTAAGTACTCATATAAGAGTTCATACAGGGGAGAAACCATATTCTTGCTCAATATGTGGAAAGGTTTTTTCACAAAACGTAGCATTACAATTTCACTTACGGAAGCATTCTGGAGAGAGTCCCCATGCTTGCCATCTTTGTGGAAAAATATGTAGATCGAAATCTGATCTAATGAGACATTTAAGAGTTCACGATAAAGAGCaagtttaa
Protein Sequence: MENSSEKTEEHFVVNISPEDVKVELSCEPDLHDYNSDTVSFSGVMYNSEISCAHSQEYSCSVYNNTVQENSEAHTTPGKTAEDEIFPCTYCEKTFSKKFGLERHLRTHTKEKPFSCTICGKSFSDCGSMKRHLRIHTGEQPHSCSICEMKFNRLYNLTLHMRTSHSKERPFACTFCEKKFAENSRLQEHLRTHTGDTPYLCTFCQKGMKSSTDLKIHLRIHTGEKPFLCTICEKRFSQSQHLSTHIRVHTGEKPYSCSICGKVFSQNVALQFHLRKHSGESPHACHLCGKICRSKSDLMRHLRVHDKEQV

Sequence clustering based on sequence similarity using MMseqs2