Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_036250285.1
Location
CM070076.1:44596514-44603099[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.5e-17 8e-14 52.4 0.1 8 74 425 490 419 494 0.90

Sequence Information

Coding Sequence
ATGGGTAGAAAATGTTATGTTCCTGATTGTCTATCGGAAGAAGGAAGGGAAGAAGATAGAGGTGTAACATTTCATAAAATACCATTACATTCCGATATTCGACCAAAATGGTTATCATTATGTCATGTACCTTCTGATAAACATAACTGCAAAGTTATACATGTTTGTTCTAGACATTTTTTAAAGGtagatttttgtaatttcaaagGTAAAAAGTATATGCTACGTCAAGGTGTATTACCTAGCGTTTTTCCTtggagtaaattaaaaaaggagCCCGAGTTGACCACCATTATAAAGAAAGAGTCTGAAGTTACCACGAAACCAATGCAAGTAGAACCCGAAATTTGTCCCGATATAGTCATGAAAACGGAAATAAAGGAAGAACCGAGTGATTTGATTCTCAATGCGGATATAAAACAAGAAAGTTTTCACGACGATTTCGCACAATGCGAAACAAGTCAACCCGTTGTCGAAAAATCCTCTACAACCATAGAACAAAAAGGCAAATCTATACAAACACCGTCGGGTTTGCTAAATTTCTCAGTCAACACCCGATTAGAAGCCTTGGATTTTAACCAAATGTGGTTCCCGGCGCATATCGTTGAAGTTGATTATGAAGAAAGCGAAGTTCttatacattttgaaaaatattcgaGTAAGTACGACGAATGGATAAGTATGAACAGCTCACGTTTAAGACCGTACCAACCCGTACAGCAACCCCAACTACCTCATACCTCGTATAGTGCAACACAACTGTCGCAACAATCTCAGACGATACAGTCTCATCGGGACTTACCTAAAAAGGGATTAAATAAAGAAGCTTTCGTCGAAGGTGAAAATGTGATGGCGTCATGGAGTGATGCTAGAAAATTTCCTGCGGTCATCAGAAAAGTTTTGGATCATGATACGTACGAAGTTCGTTTTGTTGAcggttttatgaaaatattaaaagggcACAGAATAATGAAGACACACGGTAAAATCGGTTGTGCTCCATTATTCGATCCGGCAAGTGGAACTAAACAAGATCgacgtaataaaaaacgcaaactAAATGTTGCCCAACTGTTTCGTAAACGATTAAGGGCCGATACAAGTGAATGTCTGTCCCCGTCGCCCCCGTCGATAAATATGGATGTCGGCAGTAGTAATAATAGTGGTGAAGAGACGGAAGGGTGGATGCCAAAATGGGAGAATGGGAGGCCGGTGGGTGTCGAGTCAGCTATTGAAACACATGATGGCCTTAAAAAATCCATTATGGTACCAGATCCTCGACTACCTCCTAATTGGGCTAAACATGTCATGCAAAGGAGTACTGGTGCATCTGCCGGAAAATGGGATACTATCATTGTCAGCCCAGAAGGTCGAAGATTTCGAACACGTTCAGAAATCAAGGCATTTTTAGAAGAAAACCCACAACTCAATTACAACGAGGACATGTTCACCTTTTCTCTTTATAGACGTTCAAGAACACGACGTGTAACACATAGTGTGGATGTACCTCAACATACTATAGTTCCACCACAAAAGAAACGTCAGGCACAGGATGACAGcagcaatttaaaaatattattagtcgACGATGCATACAAATGTCCAATTGCAGGTTGTGAAAAAAGTTTTCGTCGCGAAAATTTAGCCCAAATGCATGTTAAACATTATCATCCGAAATTTACAAAGTTTCTGGACTCGACACCTAACGTTGCAGATTTGGCATACGCTCGTACGGTCGGCGAATCTTTGGATAAATCGCCAGAGAGATTGGGAAAATTAACGCCAGGTAGACCTGGTAGACCTTTAGAAAAGGTGGCCACCCCAAAAGTTACAACTCCAAAACCGTCTATATCTAACGAACCTGAAATTTCTCAAGAATGTTTGGATGCGCAGGCAAgtttattacaaaaaaccaaagaTTCCGAAATTCTGAAATTGCTGAACAGTAAGCCATCCGAAGAATCCTCTACAAAGTTTCCACCAGGTTTACCATCGGGAATGTATCCCCCTATCAAACTCAAAGATCTTCTGAACAAATCGGAAGGGATTCCAAAAGGTgaggatttaaatttaaaatctttgAGTGCTAGTACAAGTAGATCTACCGGAATTAAAACGCTTTTACCCGTCGTAAGAACAAATGATGGGAAGAGGTCAGAAGAAAAAGTGTTAGAAGAGCCTTTGTTAAAAAATTCGATCAAACCTAttcttaaacaaaatttgaaacgtAAACGCTTTATTTCTGATAATACTGATGCGCCAACACCGAAAATGGTCGAAACTGAAATGGAAACTCCGGCACCGGCTGTATCCGAACAACTTACTTTACCCGAAAATAACCAAAATTATATTGTTGAAGGTGGAGAAGTTATAAAAATCGTTAGAATGAAACGTGAGGAAATTATAAACTGCACATGCGGCATTACGGAGGAAGACGGTCTGATGATACAATGTGAGCTGTGTCTATGTTGGCAACACgcttattgtaataatatagaACGAGAAAATCAAGTACCGGAGAAATATATTTGTTATATTTGTCAAAATCCCATGCGTCCACGTTCCTCTCGGAAGTATTTTCACGATCAAGACTGGTTGAAAAATGGTACGCTCCCTGTCGGTAGTTATCATTGTAAAGATGAGGATGTACATAAAAAACGAtttgaattgttaaaaaaatcgcACGATTTAAGCGGATTGCTTGTTGAGCTTAGCGATTATATGCATTCTGTTAAGGTTAAGCTGAAAATTGCGCAGACAAAGAACCATCAGAAACTTTATTTATGGTCGAAACCTTGGGAAAAACTCCCGTTACCGGAAAAAATGGAACTTGATCAAGAAAACGAAATTCCATTTAGCAAGAGCGAGTTAGATTTGTTCTCGAACAAAATCGAATCTCACAATGACTCGTCCTTACTTTCGTTATTAAAATCGCCGAAAACTGAACAGAAAATAAAAGAGGAATTATCGAAATTGGACCTAAATACACTTATAGATAACAATTTTGAGCAATTAGCAACTCCGATAATTCCGCAACCCGAAGCCGCAATTAATTCCATtgattgtaaattaaatttactagatcACATAGCACATTCGCAGAATTTAATTGAGGAACGCTTGGAAATGGTTCAAGCTCAAGTTGATGCCTTAGACGGTggtgataataataatgaggAGGATTTCAGTCATGTTTCTAAAACTGTACAAATGTTATTAAAGGACTTAGGAACACTTCAGGAATTAAGTCATAGTAGTAGTTTGTAA
Protein Sequence
MGRKCYVPDCLSEEGREEDRGVTFHKIPLHSDIRPKWLSLCHVPSDKHNCKVIHVCSRHFLKVDFCNFKGKKYMLRQGVLPSVFPWSKLKKEPELTTIIKKESEVTTKPMQVEPEICPDIVMKTEIKEEPSDLILNADIKQESFHDDFAQCETSQPVVEKSSTTIEQKGKSIQTPSGLLNFSVNTRLEALDFNQMWFPAHIVEVDYEESEVLIHFEKYSSKYDEWISMNSSRLRPYQPVQQPQLPHTSYSATQLSQQSQTIQSHRDLPKKGLNKEAFVEGENVMASWSDARKFPAVIRKVLDHDTYEVRFVDGFMKILKGHRIMKTHGKIGCAPLFDPASGTKQDRRNKKRKLNVAQLFRKRLRADTSECLSPSPPSINMDVGSSNNSGEETEGWMPKWENGRPVGVESAIETHDGLKKSIMVPDPRLPPNWAKHVMQRSTGASAGKWDTIIVSPEGRRFRTRSEIKAFLEENPQLNYNEDMFTFSLYRRSRTRRVTHSVDVPQHTIVPPQKKRQAQDDSSNLKILLVDDAYKCPIAGCEKSFRRENLAQMHVKHYHPKFTKFLDSTPNVADLAYARTVGESLDKSPERLGKLTPGRPGRPLEKVATPKVTTPKPSISNEPEISQECLDAQASLLQKTKDSEILKLLNSKPSEESSTKFPPGLPSGMYPPIKLKDLLNKSEGIPKGEDLNLKSLSASTSRSTGIKTLLPVVRTNDGKRSEEKVLEEPLLKNSIKPILKQNLKRKRFISDNTDAPTPKMVETEMETPAPAVSEQLTLPENNQNYIVEGGEVIKIVRMKREEIINCTCGITEEDGLMIQCELCLCWQHAYCNNIERENQVPEKYICYICQNPMRPRSSRKYFHDQDWLKNGTLPVGSYHCKDEDVHKKRFELLKKSHDLSGLLVELSDYMHSVKVKLKIAQTKNHQKLYLWSKPWEKLPLPEKMELDQENEIPFSKSELDLFSNKIESHNDSSLLSLLKSPKTEQKIKEELSKLDLNTLIDNNFEQLATPIIPQPEAAINSIDCKLNLLDHIAHSQNLIEERLEMVQAQVDALDGGDNNNEEDFSHVSKTVQMLLKDLGTLQELSHSSSL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01284707;
90% Identity
iTF_01284707;
80% Identity
iTF_01284707;