Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.71 5.3e+03 -2.0 0.0 58 66 6 14 2 17 0.73

2 3 1.4 1.1e+04 -3.0 0.2 14 25 68 79 65 83 0.72

3 3 2.7e-13 2e-09 37.8 10.7 4 69 92 157 89 158 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.71	5.3e+03	-2.0	0.0	58	66	6	14	2	17	0.73
2	3	1.4	1.1e+04	-3.0	0.2	14	25	68	79	65	83	0.72
3	3	2.7e-13	2e-09	37.8	10.7	4	69	92	157	89	158	0.96

Coding Sequence: ATGGAGATCACTGGAACATGTCGACTTTGTGGAGGAAAATTAAGTTTCAGAGCTGATAATCCTTACATTCTCGGGGAACATGTAATCAAAAAGCATCCAGAAGTTGAGATGACATATATTTTAGGTGACGAAGAACCCTTAAAACGTTCATCAAGAAAAAGTCGAAGCAAAATTTCTCTATTTGGAAGGAGATCCTCGTCTAGAAGTAGGACGAAGACCAAGAAGAAAAATAATTTTTATAAAACAACAGTTGAAAGTTGGCGACCAGGTGCGGCTCCTCTTTCATGCCCTTCATGTGGATGCTGTGAACAACCCTACTTACGAAAACAAAGAAATAAAGTTGCCTATAATTCTCTTGGAGCCTTCTTCTTGATGGGTTGTTGGCCGCTTTGCTTCATTCCAATGACAATGTGTGGGACTAGCGTTACTGCAGCCTGCTGCAGAAAGTGTGGTCACGTCTTTGGCGTGTATAATAGACGTAAAGGAAAACTAGAATCCCCACCTAACAATCTGAAAAGAATTAACACACCAGCTCCTCCAATTTGTTAA
Protein Sequence: MEITGTCRLCGGKLSFRADNPYILGEHVIKKHPEVEMTYILGDEEPLKRSSRKSRSKISLFGRRSSSRSRTKTKKKNNFYKTTVESWRPGAAPLSCPSCGCCEQPYLRKQRNKVAYNSLGAFFLMGCWPLCFIPMTMCGTSVTAACCRKCGHVFGVYNRRKGKLESPPNNLKRINTPAPPIC

Sequence clustering based on sequence similarity using MMseqs2