Basic Information

Insect: Pyrausta despicata
Gene Symbol: KLHL2
Assembly: GCA_963921415.1
Location: OY992863.1:143821-162684[-]

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 1.9e-10 8.9e-08 33.3 0.0 3 60 70 133 68 136 0.87

2 5 2.2e-08 1e-05 26.7 0.0 20 58 136 172 125 179 0.73

3 5 3.6e-08 1.7e-05 26.0 0.0 23 58 276 309 264 316 0.79

4 5 3.6e-08 1.7e-05 26.0 0.0 23 58 413 446 401 453 0.79

5 5 8.8e-21 4.1e-18 66.6 0.0 23 107 550 633 538 636 0.90

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	1.9e-10	8.9e-08	33.3	3	60	70	133	68	136	0.87
2	5	2.2e-08	1e-05	26.7	20	58	136	172	125	179	0.73
3	5	3.6e-08	1.7e-05	26.0	23	58	276	309	264	316	0.79
4	5	3.6e-08	1.7e-05	26.0	23	58	413	446	401	453	0.79
5	5	8.8e-21	4.1e-18	66.6	23	107	550	633	538	636	0.90

Sequence Information

Coding Sequence: ATGGAAGGAGGCGACGACCAGGACAGAGACCGCGCGCAGTTGGGTGTGGACTACAGTGCAGCGGAGGGAGATGGAGACCGTGGGAGGTACAGTTTGCTGGTACGTTGCGCGTCGCAGTCGTCCCTGGACGAGTCGTCGCAGCGGCCGCCGGCGGGCGAGGCGGGCGCGGACACGCAGCACGCGGGCAAGCTGCTCGACGCGCTCGCCCGCCTGCGCCACCTCGCCGCGCTCTGTGACGTGCAGCTGCAGgcgcagctggACAGTGCGGATTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGCTGGACAGTGCGGACTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGGTACACAGCTGGACAGTGCGGACTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGGTACACAGCTGGACAGTGCGGACTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGGTACACAGCTGGACAGTGCGGACTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGGTACACAGCTGGACAGTGCGGACTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGGTACACAGCTGGACAGTGCGGACTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGGTACACAGCTGGACAGTGCGGACTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGGTACACAGCTGGACAGTGCGGACTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGGTACACAGCTGGACAGTGCGGACTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGGTACACAGCTGGACAGTGCGGACTCGCCGAGCGAGGGCGTGTGGGCGCACCGCGCGGTGCTGGCGGCCGCCTCGCCGTACTTCCTCGCCATGTTCACGCAGTTCGGCGAGCGCACGCAGCCCGCCGTCACCATACAGAATATAGAGCCACAGGCACTAGAAGCAATCATCGAATACATTTACAACCCGGAATCTCTCGTGATCACTGAAGATAATGTACAGAGCCTGCTGTCGGGCGCGTCGCTGGTGCAGGTGTGGGGCGTGCGCGCGGCGTGCTGCGCGTTCCtggcgcgcgcgctcgcgccCGACAACGCGCTCGGCATCCGCGCCTTCGCCGACCTGCACGCCTGCGCAGACctcgcgcgcgccgcctcgcGCTACATCGACGCGCACGCGCAGCAGGTACGTACAGACGCGCCCGACAACGCGCTCGGCATCCGCGCCTTCGCCGACCTGCACGCCTGCGCAGACctcgcgcgcgccgcctcgcGCTACATCGACGCGCACGCGCAGCAGGTACGTACAGACGCGCCCGACAACGCGCTCGGCATCCGCGCCTTCGCCGACCTGCACGCCTGCGCAGACctcgcgcgcgccgcctcgcGCTACATCGACGCGCACGCGCAGCAGGTACGTACAGACGCGCCCGACAACGCGCTCGGCATCCGCGCCTTCGCCGACCTGCACGCCTGCGCAGACctcgcgcgcgccgcctcgcGCTACATCGACGCGCACGCGCAGCAGGTACGTACAGACGCGCCCGACAACGCGCTCGGCATCCGCGCCTTCGCCGACCTGCACGCCTGCGCAGACctcgcgcgcgccgcctcgcGCTACATCGACGCGCACGCGCAGCAGGTACGTACAGACGCGCCCGACAACGCGCTCGGCATCCGCGCCTTCGCCGACCTGCACGCCTGCGCAGACctcgcgcgcgccgcctcgcGCTACATCGACGCGCACGCGCAGCAGGTGTTGGAGACAGAAGAGTTCCTCTCGCTCGCACCCGACGTGCTCTGCCAGCTGTTAGACAGCGATCGCATCACGGTacccaatgaagaggtgatccTAGACGCTGTCATTCGTTGGATGCAGCACGATCCTGAGTCCCGCTCCGAGTCGCTGGGCGCGGTGCTGGAGCACGTCCGCCTGCCGCTGCTGCCGCAGGACGTGCTCgtggcgcgcgccgccgccgagcCGCTCGCCTCCGCGCCCGTGCGCGTCAAGGACCTAGTGATCGAGGCGTTATCATTCCACCTGCTGCGCCCGGAGCGTCGCGTGGCCGCCGCGGCGGGCTGCGTGCGGGCGCGCCCGCGACACGCCGCGCGCGTCACGCCCGCCGCTGCCTTGCTCGTCGTGGGCGGGCAGGCGCCCAAGGCGATCCGCGACGTGGAAGCGTTCCACCTGGGGTGCGGGCGCTGGCGCGCGGCGGCGTGCCTGCCGGCCCGGCGCTGCCGCGCGGGGCTGGCGCGCGTGGGCGGGCGCGTGTGGGCCGTGGGCGGGTTCAACGGCACGTTGCGCGTGCGCTCCGTCGACGTGTACGACGCCGCCAGCGACGCGTGGACGCCGGGCCCGCCGCTGGCCGCGCGCCGCTCCACGCTGGGCGTCGCCGTCATTGGGAACGTCATCTATGCGGTCGGCGGGTTCGACGGAGTGACGGGGCTGAACACGGCGGAGGCGCTGGACACGTCCGAGGCCGAGGGGGCgacgggcgcggggggcgcgggggctgcggggggcgcggcgggcgcgtggCGCGCGATCGCCCCCATGTCCACGCGCCGCTCGTCCGTGGGCGTGTGCGTGCTGGACGAGCGCCTCTACGCCGTCGGTGGCTACGACGGCGCGTCCCGCCAGTGCTTGCAAACGGTTGAGAGATACGACCCGACCCGCGACGTGTGGGAGCCGTGCCCGGAGATGGCGGCGCGGCGCTCGGGCGCGGGCGTGGGCGCTGCGGGGGGCGCGCTGTACGCCGTGGGGGGGCACGACGGGCCCGCCGTGCGCCGCTCCGTCGAGCGCCTGCGCCCCGGGGCCAGCGCCTGGGCCCCTGCGCCGCCCATGCACACTGCGAGACGGAATGCGGCGGTCGTGTCGCACGGGGGGAAATTGTATGTGGTGGGTGGGGATGATGGTGCGGCTAATCTTGATACTGTAGAGGTGTTCGACCCAGCAACGGAGACGTGGTCGATCCTGAGCGAGCGCATGTCGCCGCGCGGGCCCGAGCCGGCGCCCCtgccgccccccgcgcccctGCCGCCCCCGCCGCGCCCCCACCGCGTGCACGTGCACCTGCACGACGCGCAGCAGGCGCAGCCttacGCGAATGTGGGCATCTACGGGGTAGGGCTGGGCGTGGGCGTGGGCGTGAACGTGGGCGCCGCGCAGCCCCCCGCCGCGCGCTGGCGGGCGCTGTACGCGCGTCGCCCGCTGCGCCCCATCGCCGACCAGGCGCAGCAAGCGGAGAACGTGTACGAGAGCGTGAACTTCCccggggcgggcgcgggctcgGGCGGGGGCTCGTACTGGTGGTGGCGCGTGGCCCCCGCGGCCCCGGCACCCCCCGCGGCCCCCGCGCCCCGCGCCTGCCGCCACGCGCGCGCCAGCCAGACGCTCGAGTTCAACGAGCGCGCGCCCACCGCAGCCCCGCAGGAGTATCAAGGCACGATGCCGCGCGCGAGCCGCGCCGGGCGCGCGGGCGCGTCCCCCGAGGCGGAGTGCGACgccgcggggggcgcggggggcgcggcgggggcgggggcggcggggggcgcggcgcgcgggcgggcgggcgcgcgcCTGTCGGCCTCGTGCGGCACCATCAGCGTGGAGGTGCCGCCGTGCGTGCTGCTGCTGCCGGCCGCCCGCTGGCGCGCGCCGCGGCCcggcccgcccgcgccgcccgcgccccccgcgcccccgcGGCCCTCCTGCTCGTACCACCTGCTGCCCGAGAGCCACCGCGTGCTGCCCTTCGTCTGCCACCAGGTACAGAGCACGAGCCGCGAGTGCTGCTCGGACTCGGAATCGGAGCTTCGCGACTCGGAGGAGGGCGTGCCCTCGGACTCCGAGTCCGAGCAGGCCTCGCGCCCCCCCTCGCCGCCCCcagcgccccccgcgccccacGCGCCCCACGACAACGAGCGCGACGACTGA
Protein Sequence: MEGGDDQDRDRAQLGVDYSAAEGDGDRGRYSLLVRCASQSSLDESSQRPPAGEAGADTQHAGKLLDALARLRHLAALCDVQLQAQLDSADSPSEGVWAHRAVLAAASPYFLAMFTQFGERTQPAVTIQLDSADSPSEGVWAHRAVLAAASPYFLAMFTQFGERTQPAVTIQVHSWTVRTRRARACGRTARCWRPPRRTSSPCSRSSASARSPPSPYRYTAGQCGLAERGRVGAPRGAGGRLAVLPRHVHAVRRAHAARRHHTGTQLDSADSPSEGVWAHRAVLAAASPYFLAMFTQFGERTQPAVTIQVHSWTVRTRRARACGRTARCWRPPRRTSSPCSRSSASARSPPSPYRYTAGQCGLAERGRVGAPRGAGGRLAVLPRHVHAVRRAHAARRHHTGTQLDSADSPSEGVWAHRAVLAAASPYFLAMFTQFGERTQPAVTIQVHSWTVRTRRARACGRTARCWRPPRRTSSPCSRSSASARSPPSPYRYTAGQCGLAERGRVGAPRGAGGRLAVLPRHVHAVRRAHAARRHHTGTQLDSADSPSEGVWAHRAVLAAASPYFLAMFTQFGERTQPAVTIQNIEPQALEAIIEYIYNPESLVITEDNVQSLLSGASLVQVWGVRAACCAFLARALAPDNALGIRAFADLHACADLARAASRYIDAHAQQVRTDAPDNALGIRAFADLHACADLARAASRYIDAHAQQVRTDAPDNALGIRAFADLHACADLARAASRYIDAHAQQVRTDAPDNALGIRAFADLHACADLARAASRYIDAHAQQVRTDAPDNALGIRAFADLHACADLARAASRYIDAHAQQVRTDAPDNALGIRAFADLHACADLARAASRYIDAHAQQVLETEEFLSLAPDVLCQLLDSDRITVPNEEVILDAVIRWMQHDPESRSESLGAVLEHVRLPLLPQDVLVARAAAEPLASAPVRVKDLVIEALSFHLLRPERRVAAAAGCVRARPRHAARVTPAAALLVVGGQAPKAIRDVEAFHLGCGRWRAAACLPARRCRAGLARVGGRVWAVGGFNGTLRVRSVDVYDAASDAWTPGPPLAARRSTLGVAVIGNVIYAVGGFDGVTGLNTAEALDTSEAEGATGAGGAGAAGGAAGAWRAIAPMSTRRSSVGVCVLDERLYAVGGYDGASRQCLQTVERYDPTRDVWEPCPEMAARRSGAGVGAAGGALYAVGGHDGPAVRRSVERLRPGASAWAPAPPMHTARRNAAVVSHGGKLYVVGGDDGAANLDTVEVFDPATETWSILSERMSPRGPEPAPLPPPAPLPPPPRPHRVHVHLHDAQQAQPYANVGIYGVGLGVGVGVNVGAAQPPAARWRALYARRPLRPIADQAQQAENVYESVNFPGAGAGSGGGSYWWWRVAPAAPAPPAAPAPRACRHARASQTLEFNERAPTAAPQEYQGTMPRASRAGRAGASPEAECDAAGGAGGAAGAGAAGGAARGRAGARLSASCGTISVEVPPCVLLLPAARWRAPRPGPPAPPAPPAPPRPSCSYHLLPESHRVLPFVCHQVQSTSRECCSDSESELRDSEEGVPSDSESEQASRPPSPPPAPPAPHAPHDNERDD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -