Pdes030171.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Pyrausta despicata
Gene Symbol
PAX2
Assembly
GCA_963921415.1
Location
OY992869.1:9634204-9685912[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1.1e-69 1.5e-66 223.1 0.1 1 119 48 166 48 170 0.99
2 3 3.1e-18 4.3e-15 56.8 0.0 78 124 202 248 195 249 0.93
3 3 1.9e-24 2.5e-21 76.9 0.1 70 125 247 302 246 302 0.98

Sequence Information

Coding Sequence
ATGATGTCTATCCGGTTATCCGGTCCGTTTATCCGAAATCAAAACAGCGCGCATCGGGCGAGGGCGTGCCCGATCGATGCCGTCACGCCCGCCGCGCACCGTAGCTTGCCCTTCGCGGAAACATCTTGTGCTGTGTGTGTAGGTCACGGCGGCGTAAACCAACTAGGTGGAGTCTTCGTGAACGGACGACCTTTGCCCGACGTGGTCCGACAGAGGATAGTCGAGCTGGCTCACAGCGGAGTCAGGCCGTGTGACATCAGCAGACAGCTGAGGGTGTCGCACGGATGCGTCTCCAAGATACTGTCTAGGTATTACGAAACGGGCAGTTTCAAGGCCGGCGTCATAGGGGGCTCCAAGCCGAAGGTGGCGACGCCGCCCGTGGTGGACGCCATCGCCGCGTATAAGAGGGAGAACCCCACGATGTTCGCGTGGGAGATCCGCGACAGACTGCTGAGCGAGGGGATCTGCAGCCAGGACAACGTGCCTTCAGTGTCCAGTCCTGACGGGCTACATGACCGAAATCTAACTTACGTCCGTGCAATAACACCCGAGTACACTTGCGGTATTCTATCGCCGCTACTCGTGACAGTTATCTCTGTAGCGGCGACCGTGGTGGACGCCATCGCCGCGTACAAGAGGGAAAACCCCACGATGTTCGCGTGGGAGATCCGCGACAGACTGCTGAGCGAGGGGATCTGCAGCCAGGACAACGTGCCTTCACTGTCCCGTATCAAtagGGGGCTCAAGCCGAAGGTAACGACGCCGCCCGTGGTGGACGTCACCGCCGCGTACAAGAGGGAGAACCCCACGATGTTCGCATGGGAGATCCGCGACAGGCTGCTGAGCGAGGGGATCTGCAGCCAGGACAACGTGCCTTCAGTGTCCAGTATCAATAGGATCGTCCGCAACAAGGCAGCAGAGAAGGCGAAGCACGCGCACAACcagcagcagcaacagcagCAAGAGCAGGAGATCAGCTCAGCGCAGGGCAGTGTTGTTTCTGTGATCACGCATGCCGGTAACGCTCCCGGCACAACAGCTGTTCTGTCCCCCACCACGGACCAGCATGTCACAAACACAGGGAGCTACAGCATCAACGGCATCCTGGGCATCGAGCAGGTCGACGGACTTCATAATGGCACGACAGGGCTGAAGAGGAAGAGACACGAAGATCAAGACGAAAACCGGGACTTCAACAGCCATTCGGAGGACGACGTGAAAAGACAGCGGAGCCATTACAATGGCGATCAAATATATTCCAATCTCTGGTCGTCATCCAAATGGAGTCTGAAGGACGAATACAAACTGCTGTCGGAgctgggcggcgcggcgggggcgggcggcgcgcccGGCTACTACGGCGAGCTGTTCGACGCGCCGTACGAACACGCCGCGCACCCGCACTACACGCCGCACTCTGCAACGAACGACTCCACGGGCTCCAACGGCGGGACGGGTGCGGAGCCCCCATCGGCTGCAGCCAGCCCGGACGCGACGGCGTTGGTGGTGCTCCAGCCGCCTGCGCCCTACCCACCGTACGCGCACTATGATGGTAAGTGGAACTTACTGTTCTACATTCTCACTAGTAGAGAATTCCCAAAAGTACGACTCCACATGCGCCAACTGCGGGACAGGTGCGGAGCCGCCATCAGCTGCAGCCAGCCTGACGGCGTTGGTGGCACAACAACACTGGCGAGCGAGTACGCATACGCGGCGCCTTACTCGCAGTACTCGCCGTACGGAGGGCCGTACTCGCACTCCGCCGCTACGGGTCTGCTGTCCAAGTGGTCGAAATCTCAAGATCAGCAACCCAAACCTGTATGCACCAAAGAGATAACACagaactgcatcccaccaaaggacgatgatgatgatgccccTCGCCCTAAGCCTCCTTGCAAGAAAAGAGTGGAGAGTGCCAAATGTgcgaagaagaagagaaaaagtGCTGGATAG
Protein Sequence
MMSIRLSGPFIRNQNSAHRARACPIDAVTPAAHRSLPFAETSCAVCVGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHSGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIAAYKRENPTMFAWEIRDRLLSEGICSQDNVPSVSSPDGLHDRNLTYVRAITPEYTCGILSPLLVTVISVAATVVDAIAAYKRENPTMFAWEIRDRLLSEGICSQDNVPSLSRINRGLKPKVTTPPVVDVTAAYKRENPTMFAWEIRDRLLSEGICSQDNVPSVSSINRIVRNKAAEKAKHAHNQQQQQQQEQEISSAQGSVVSVITHAGNAPGTTAVLSPTTDQHVTNTGSYSINGILGIEQVDGLHNGTTGLKRKRHEDQDENRDFNSHSEDDVKRQRSHYNGDQIYSNLWSSSKWSLKDEYKLLSELGGAAGAGGAPGYYGELFDAPYEHAAHPHYTPHSATNDSTGSNGGTGAEPPSAAASPDATALVVLQPPAPYPPYAHYDGKWNLLFYILTSREFPKVRLHMRQLRDRCGAAISCSQPDGVGGTTTLASEYAYAAPYSQYSPYGGPYSHSAATGLLSKWSKSQDQQPKPVCTKEITQNCIPPKDDDDDAPRPKPPCKKRVESAKCAKKKRKSAG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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