Pful030174.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Pycnomerus fuliginosus
Gene Symbol
Foxd3
Assembly
GCA_963924575.1
Location
OZ004626.1:5364388-5365257[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.2e-36 8e-33 113.3 0.0 2 87 75 157 74 158 0.96

Sequence Information

Coding Sequence
atgtgcAGTAACGAAACTCCGGCAAACCCTTCACCCAGATTGCCAATTCCCTTCGCTTTGGATGGGAACAATCCTAGGGCCCTTTTGCCAATTGAACAATACCGCCTGCAGCTGTATCAATATGCCGTCGCGGAGCGACTTCGATATCCACTTTTAAATCCTTTTCCAACACCTTTAACGTGTTATCCATTGTTTCCAAGGGCCTTGCAACCGGAAGAACCAAAACCACAACATAGCTACATAGGATTAATCGCTATGGCTATTTTAAGCTCCCCCGAAGGCAAATTAGTGCTTTCCGATATTTACCAACATATCCTGGACCATTATCCTTACTTTCGGACAAGAGGCCCCGGCTGGAGAAACTCGATAAGACACAATTTATCCTTGAACGATTGTTTTATAAAAGCCGGAAGGAGTGCAAACGGAAAGGGGCATTATTGGGCCGTCCACCCGGCAAATGTTGACGATTTTCGAAAAGGCGATTTCAGGAGGCGCAAAGCGCAGCGGAAAGTAAGAAAACATATGGGACTTGCTGTGGATGAGGACGGGGCAGATTCTCCAAGTCCACCACCGTTATCAGTGACTCCCCCCTCCGTCGTTCCGGGACCATCCACGTCTGTTTATCACCAGGTGCCGACGAGGGGTCCGTCGCGGAAACGGCAATTCGACGTCGCGTCGCTTCTAGCACCGGATTCGGGAGAGGACACCAACGAAGAGGACATAGACGTCGTTACTAGCGATCAACAGGAGCAAAATTCGCAAAAACAGTGGCCTATGTTCCCGATTGTTAATTATTACCAAGCTCTGTTGCAAGCGAGGCCGCCGGGGCCTCCTACAGAAAATGTCACAGACAGCTCGGCAGACCCTTAA
Protein Sequence
MCSNETPANPSPRLPIPFALDGNNPRALLPIEQYRLQLYQYAVAERLRYPLLNPFPTPLTCYPLFPRALQPEEPKPQHSYIGLIAMAILSSPEGKLVLSDIYQHILDHYPYFRTRGPGWRNSIRHNLSLNDCFIKAGRSANGKGHYWAVHPANVDDFRKGDFRRRKAQRKVRKHMGLAVDEDGADSPSPPPLSVTPPSVVPGPSTSVYHQVPTRGPSRKRQFDVASLLAPDSGEDTNEEDIDVVTSDQQEQNSQKQWPMFPIVNYYQALLQARPPGPPTENVTDSSADP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00986949; iTF_01366151; iTF_00929385; iTF_01022033; iTF_00813531; iTF_00841659; iTF_00395068; iTF_00853763; iTF_00152071; iTF_01515303; iTF_00267948; iTF_00270865; iTF_00977137; iTF_01293393; iTF_00788338; iTF_00838229; iTF_00927318; iTF_00272279; iTF_00003579; iTF_00151707; iTF_01291292; iTF_00641213; iTF_00398654; iTF_00269568; iTF_01345507; iTF_01210027; iTF_00949612; iTF_00950531; iTF_00030007; iTF_01294775; iTF_00031608; iTF_00030813; iTF_01039043; iTF_01039938; iTF_01040678; iTF_00049075; iTF_00169021; iTF_01368835; iTF_01441764; iTF_01014061; iTF_00110352; iTF_01295792; iTF_00885714; iTF_01310136; iTF_01289563; iTF_00391780; iTF_00392568; iTF_00814213; iTF_00020007; iTF_00328967; iTF_00387873; iTF_00436289; iTF_01046919; iTF_01105385; iTF_00386996; iTF_00791894; iTF_00025847; iTF_00458681; iTF_00910334; iTF_00735295; iTF_00064996; iTF_01498695; iTF_01107002; iTF_00115515; iTF_00330346; iTF_00764490; iTF_00348641; iTF_00130306; iTF_01023655; iTF_00964943; iTF_00998364; iTF_00415703; iTF_00394096; iTF_00852493; iTF_00626884; iTF_01241642; iTF_01128130; iTF_00443755; iTF_01238379; iTF_01186833; iTF_00845685; iTF_01239929; iTF_00195772; iTF_00167502; iTF_01311375; iTF_00413304; iTF_00431295; iTF_00830055; iTF_01566061; iTF_00903919; iTF_00646608; iTF_00056359; iTF_01409768; iTF_01096430; iTF_00740632; iTF_00465804; iTF_00920477; iTF_00639349; iTF_01162902; iTF_01344726; iTF_01121395; iTF_00048476; iTF_00755260; iTF_00327670; iTF_00423550; iTF_01479937; iTF_00870375; iTF_00414873; iTF_00752761; iTF_01567642; iTF_01480671; iTF_00902053; iTF_01185998; iTF_00721814; iTF_00078200; iTF_01215769; iTF_00244027; iTF_00956125; iTF_01120692; iTF_01252543; iTF_01329600; iTF_01283124; iTF_01226431;
90% Identity
iTF_01479937;
80% Identity
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