Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 2.2 6.3e+03 -2.7 0.0 26 43 131 148 126 152 0.72

2 6 0.0067 19 5.4 0.1 26 47 159 180 154 187 0.91

3 6 0.00042 1.2 9.3 0.1 25 52 188 215 182 217 0.88

4 6 0.00044 1.2 9.2 0.0 21 45 240 264 234 268 0.90

5 6 0.0052 15 5.7 0.0 21 48 303 330 295 334 0.85

6 6 0.0034 9.6 6.3 0.4 21 46 331 356 327 357 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	2.2	6.3e+03	-2.7	0.0	26	43	131	148	126	152	0.72
2	6	0.0067	19	5.4	0.1	26	47	159	180	154	187	0.91
3	6	0.00042	1.2	9.3	0.1	25	52	188	215	182	217	0.88
4	6	0.00044	1.2	9.2	0.0	21	45	240	264	234	268	0.90
5	6	0.0052	15	5.7	0.0	21	48	303	330	295	334	0.85
6	6	0.0034	9.6	6.3	0.4	21	46	331	356	327	357	0.91

Coding Sequence: atgatTGAATCATGCAGAAACAAAACAGATTCAGACGACGATGACGAAGTACAATTAGTTATTCCTGATGATCCATTGAATGAGTgctttttagataatttagaAACGAATGATATTAGCTGTGATAAAACTAAAACGAATACAATTTCTGGTgaaaaaattactattaaaaaaaaagaaaaaattggaATGCTAAAGGTGAATGAATTGTTAAAGACCTACAAATGCTCAGATTGTGACAAAGTGTTTAAACGTGGATCATCATTAGCAAATCAccagaaaaatcatttacgTGATAAAACATTTGACTGTAATTTatgtgataaaaaatttaaacgtaATTCGAGTTTAGTATCACACATTAAGGTTCATGCTGGCGAACGttcatataaatgtaaatattgtcCACTTACCTTTTGGAAGTCATCGAATCTATTAAAACATGAAATTTTCCATACTGGTGACACACGTTTACAATGTCGTCTCTGTAAGGTTGTTCTTAGTACTAGTGAGAAGTTGGAGAAACATCTCAAATTACACGCAAATCGAGCATCCGATGTCTTTACATGCGAAGTTTGTGGTAAGATTTTTCACAAAGCTAGAAACCTGTCTATGCATATGCGATTGCACACCGGTCATAAGCCATTCCATTGTGAAATATGCGATAAATATTTCTCACAACGTAGTGTCTACACAATACACAAGCGAATGCACACTGGAGAACGACCGTTCAAATGTACATTGTGCAACAAAGGTTTTCAACAAAGTTCTAACCTTAAAACCCATATGAAAAGCCATGCCAACGAGTTGGGTACCACCGATACGATAAAAGTGCATTCCTGTAATTTTTGCGGCAAGTGTTTTGCTTATAAAAATCACGTTATACGACATAAACGTATTCATACCGGTGAACGaccatttaaatgcaaaatatgTGAGAAATCATTTACGCAGTCCGGTTCACTTGTTGAACATATACGAATTCATACAGGTGAAAAACCTTACAAGTGCAACGTTTGCAGTAGAAGCTTTACTCAATCATGTAGTTTAAAGCaacatattaaaatacattaa
Protein Sequence: MIESCRNKTDSDDDDEVQLVIPDDPLNECFLDNLETNDISCDKTKTNTISGEKITIKKKEKIGMLKVNELLKTYKCSDCDKVFKRGSSLANHQKNHLRDKTFDCNLCDKKFKRNSSLVSHIKVHAGERSYKCKYCPLTFWKSSNLLKHEIFHTGDTRLQCRLCKVVLSTSEKLEKHLKLHANRASDVFTCEVCGKIFHKARNLSMHMRLHTGHKPFHCEICDKYFSQRSVYTIHKRMHTGERPFKCTLCNKGFQQSSNLKTHMKSHANELGTTDTIKVHSCNFCGKCFAYKNHVIRHKRIHTGERPFKCKICEKSFTQSGSLVEHIRIHTGEKPYKCNVCSRSFTQSCSLKQHIKIH

Sequence clustering based on sequence similarity using MMseqs2