Basic Information

Gene Symbol
Mbd2
Assembly
GCA_963942525.1
Location
OZ012639.1:5068280-5069679[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.4e-25 5.7e-22 77.0 0.0 1 74 5 73 5 76 0.95
2 2 0.0017 4.2 7.0 0.0 29 72 118 169 79 173 0.78

Sequence Information

Coding Sequence
atgaatatatcaatagagagaaaaaagaCAGATTGCACAGCTCTGCCAAAAGGTTGGCAACGTGAAGAAGTCCTACGAAAGACTGGATTATCCGCAGGCAAAgctgatatttattattatagtcCAACAGGTAAACGTATTGATACGAAACCACAATTATCACGTTATTTGGGTGATGCCATTGATTTATCAACATTTGATTTTCAAActggaaaattaataaattctcagCAAATGTTATTTCAACGAtcgacaataaaaaaaaatttaccaaataCAACGATACAtccaacaacagcagcagcagttgCCGCAGCAGCAGCCAAACATCAATTTGATTACAGtcGCGGAATCCGTACAGATGCATCATTAGTGCCGCCAATTCGACAAACCGCATCGATATTTAAACAACCAGTTACCGTGTATAAAACACAAGAGGCAAAAGTGAAACCAGACTTAAAGCATGGAACTCAGGATAAACCGAAACAATTATTTTGGGAAAAACGTTTAGAAGGTATGCGTGCATGTGATGTTGATGGTTCTGAGTTTGGTCCCGTTGAATTACCAAAAACATTAAAGCCAGTCGGTCCAAATGTTAATGAGGGTACACTTTTACAATCAATTGCCACCGCATTACATGTCTCAACACAACCGGTTACTGGTCAAACAGCAcataaaacaacattaaatacaaattctgGTGTTTTCTTAAATCCAGATCAACCATTAATGCATGCTATTAATATCACCGATGATGATATACGTCGACAAGAGGATCGTGTGCAATTAtctagaaaaaaattacaagacgctttaattgtttaa
Protein Sequence
MNISIERKKTDCTALPKGWQREEVLRKTGLSAGKADIYYYSPTGKRIDTKPQLSRYLGDAIDLSTFDFQTGKLINSQQMLFQRSTIKKNLPNTTIHPTTAAAVAAAAAKHQFDYSRGIRTDASLVPPIRQTASIFKQPVTVYKTQEAKVKPDLKHGTQDKPKQLFWEKRLEGMRACDVDGSEFGPVELPKTLKPVGPNVNEGTLLQSIATALHVSTQPVTGQTAHKTTLNTNSGVFLNPDQPLMHAINITDDDIRRQEDRVQLSRKKLQDALIV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01276261;
90% Identity
iTF_01276261;
80% Identity
-