Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 8 1.4e+04 -4.2 1.2 60 66 8 14 4 23 0.48

2 4 5.7 1e+04 -3.6 0.4 57 62 169 174 160 176 0.64

3 4 3.9e-16 6.9e-13 48.2 2.3 3 70 240 307 238 307 0.93

4 4 3.6 6.4e+03 -2.9 0.5 55 64 327 336 324 339 0.72

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	8	1.4e+04	-4.2	1.2	60	66	8	14	4	23	0.48
2	4	5.7	1e+04	-3.6	0.4	57	62	169	174	160	176	0.64
3	4	3.9e-16	6.9e-13	48.2	2.3	3	70	240	307	238	307	0.93
4	4	3.6	6.4e+03	-2.9	0.5	55	64	327	336	324	339	0.72

Coding Sequence: atggtGTTACGTGTTCGCTGTCTTTTGTGTAGTAAAATATTAGAGTGTCAACGTAATGACACAACATGTTTATTAGATCATATTAATTTGGAGCATCCTAATGTTACATTATCTCGTATATCCAATCAGtttGATGAAACTGATTTACCATTATTAGAAACCCAAGAAGCAACAATGTCGGAAAATAACAATGACAATAAATTAGCAGGTAATGATAGTTCACACGAAATTTTTCACTCCGCTGATAATATAAATAGGAATTCGGAtacatttaatgaaaaaaagaggacaagttttaacaataataattgttacatCGATTGTGAGTgtcaattaaataagaaaaattcagCAACATCAAAACTATCGACGATACCTGAAACCGAGTCGACACACTCGTCGCGGAATAATAGTAGAAAAGTAAATTCACAATTGGGTTCCCATACGGATGAGGAGTTGCACACATTTATAAAGAGTTTAATAGCTAAGGAGagtgctaaaataaaatcgtgtACCTGTTGTTACGTAAAAAATGACAATAATATGCCAAACGGTGAATTATCTAGTCACGATAAAATGGAGGAGAAAATCATAACCGATAGTACTGACACAAAAgttttgtataaaagaaaatacaaaccGATGAAACCGATTaaatttggtaataaaaataaaagaaaattatataaaacctCAGTTGAAAAATGGCGTCCAGGTAGCTCAAAGATCACATGTCCAGAATGTGGTGAAACTAGACGACCGGTTATACGATCACATGCTGATCGGGTATCACGTTCATCGTTTGGTGCCGCATTAATTCTTACATGCTGGCCGTTGTGCTTTCTCCCCTGTCTGTTTCCACCGCCAACCGCTGAATACTTGCATTGCTCACAATGCAATCACTTTCTTGGACAATACAATCATAAAAGCAACAAAGTACAACCGAATGAAGAGTCCTTTGAGGAGAAACCAGTTGACTGCACCGACTCTTGCGACGGTTGCAAAGCGTTTAGAACCGATAAGGACGAaattaatgtagaaaaatcactaaaatcagaatga
Protein Sequence: MVLRVRCLLCSKILECQRNDTTCLLDHINLEHPNVTLSRISNQFDETDLPLLETQEATMSENNNDNKLAGNDSSHEIFHSADNINRNSDTFNEKKRTSFNNNNCYIDCECQLNKKNSATSKLSTIPETESTHSSRNNSRKVNSQLGSHTDEELHTFIKSLIAKESAKIKSCTCCYVKNDNNMPNGELSSHDKMEEKIITDSTDTKVLYKRKYKPMKPIKFGNKNKRKLYKTSVEKWRPGSSKITCPECGETRRPVIRSHADRVSRSSFGAALILTCWPLCFLPCLFPPPTAEYLHCSQCNHFLGQYNHKSNKVQPNEESFEEKPVDCTDSCDGCKAFRTDKDEINVEKSLKSE

Sequence clustering based on sequence similarity using MMseqs2