Basic Information

Gene Symbol
Aef1
Assembly
GCA_961205885.1
Location
OY540804.1:7117571-7117966[+]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0006 1.1 9.2 0.0 21 51 14 44 6 45 0.86
2 4 5e-05 0.088 12.6 0.0 21 50 42 71 40 73 0.87
3 4 0.0048 8.5 6.3 0.0 21 51 70 100 68 101 0.87
4 4 0.00016 0.28 11.0 0.1 21 46 98 123 95 128 0.91

Sequence Information

Coding Sequence
ATGTCGAGAGCAGTAAGTAGAACTATGAAGATAAATAGTGGCGAAAAGCCGTTTCAGTGCGAGATCTGCGAAAAGAAATTCCGTCAACTAAGTACATTAACCAACCACATGAAAATCCACACGGGTGAAAAACCTTTCAAGTGCACTATTTGCCAGAAAGATTTCCGGCAATCAAGCACATTAACAAATCACGTAAAAATACATACAGGCGAAAAACCATTTCATTGTACTTATTGTGGTAAACAATTTCGACAATTAAGTACGTTAACAAATCATTTGAAAATACATACCGGTGAAAAACCATTTGAATGTGCTGTatgtaaaaaacaatttcgtcAATCAAGTACACTtaataatcatattaaaatacatgcaggagataaaatgtttatgtgA
Protein Sequence
MSRAVSRTMKINSGEKPFQCEICEKKFRQLSTLTNHMKIHTGEKPFKCTICQKDFRQSSTLTNHVKIHTGEKPFHCTYCGKQFRQLSTLTNHLKIHTGEKPFECAVCKKQFRQSSTLNNHIKIHAGDKMFM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2