Basic Information

Insect: Pterostichus niger
Gene Symbol: MBD-R2
Assembly: GCA_947425015.1
Location: OX380339.1:6015250-6019274[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.3e-14 2.5e-10 41.3 0.0 6 69 416 477 411 485 0.87

2 2 5 3.8e+04 -4.1 0.0 42 57 1080 1095 1080 1100 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.3e-14	2.5e-10	41.3	0.0	6	69	416	477	411	485	0.87
2	2	5	3.8e+04	-4.1	0.0	42	57	1080	1095	1080	1100	0.84

Sequence Information

Coding Sequence: ATGGGTCGTAAATGTAATGTGTTAGATTGTCCATCTGATTCCAGACGCCCCGAAGATAATGGTGTAACGTTTCATAAAATGCCTTTTCATCCTGATTTGCGACCAAAATGGATTGAGTTATGTCGCATTCCAGAAGAAAGACAAATAAATAAAGTGATTTATGTTTGCTCAAGGCATTTCCGGCGAACAGATTTTTGTAATTTTAAAGGTACAAAATACATGCTCAGGCAGGGAGCTTTGCCCTCTGTTTTCCCATGGACCAAAAGCCTTATTAAATCAGCACAACAAACTCCCAAGCTTGCAATTCCAATGGAAGAGGATTCTGAAAATGTAGAAATTAAAACTGAACCGCTAGATGAGGATGAGCAACCCAGTATTGATGATATGGCAGATAAATTAGAATTAGAAACAGAACTACCAGAAGAACCTGAGGATGAAAAGCCTAAAATTAAGAAAGAACCATCTACTTCAGTTAAAAAAGAACCTCCTATACCAATAAAAAAGGAACCTATTGATGAAATATTGATCCCTGCTCCTGAGATTAAAACAGAACCTATAACTTTTTTACCAGGATCTCGAATAGAAGCCAGTGATTTTAACGAAAAATGGCACCCTGCAACTATTTTAGAAGTAGATTACGATGAAAATGAAGTATTCGTTGAATTTGACAAACAATTAAATAAAGCAAATGAATGGATACCGATGGACAGTTCCAGATTGAGGCCTTTTCAACCTCCAAGTAGTGTTGAAACATACGCTGTTGGAGAAAAAGTAATGGCAACTTGGGTAAAAACATGCAGTAAATTTCCAGCAACAATACGAAAAGTTTTAGATACAGACACTTACGAAGTTTTATTTGACGATGGTTTCTCAAAAATATTAAAACATCACAAAATAGATAAAGTTAGTTCTGCTGCTTCTTCTATCCAAAAAGCTCCATTGCATCACGTATCACCATTATTTGATCCAGTAGTAGGATCAAAAGAAGAACGACGAGAAAGGAAACGAAAATTAAATGTAGCCGAGTTATTCGGCATTGGAAAAATTAGTAATAAGAAATATAAATCAGATGATTATTTTAAATCTGAACCAGAAGATGATGTACAATCGCAAGAGGATTTTCGAAGTACAGGTTCATCTAGTCAATGTGAAGGTGAAGAATGGACTTGTCGATGGTTAAATGGCGAACCAGTTGGCATCGAATCTGAATTAGAAGGAGTGGATGGTCCTAGACGTTCAATTATTGTTGCTGATCATCGGCTACCTCCTGGCTGGGAAAAACATTTAACACAAAGATTGAATGGAACTTATGCTGGAAAATGGGATGCAATTATAATCAATCCACATGGAAAAAGATTTGCTCATCGACATATGGTAAAGTCATGGTTGGAAGAAAACAAACTAGATTACAATATCGATCGATTTGATTTTTGTTTACATTTGCATCGTGCTCGAAAATTAGGATTATATGAAGTGACTGATCCGGAAGCTTTGGCCGCCGCGAAAGCTACAGCTTTAGCTAAAAGGTCAGCAACGAAAGGTACCAAAGAATCATCCAAATCCCATAGTAACAAAATGTCAACGCCTAAGAGTGGAAGTACTATTAATTTACCAGTAACTCCGGAAAGCATTGAACCTGAACCTATAGAAGAAGATACTTCAGGATGTTTGAAAATAATCCACGAAGACGGAAGTTATAAATGTCCAATAGATGGATGTGGAAAAATTTTTCGTAAAGAAAATCTAGCGCAAATGCATGTTAAACATTACCATCCAGAATCTGCAAAACTTCTTGGTTCAACTCCCAACGTAGCTGACTTGGCTTACGCTAGAACAGTTGGTGAACACATAGACGATATAATACCTAAATCAAGATCCGTTGGGTCACCTCTAGAAAAAGAAAAGATCATTAAGACAGAATCTACTCCAAAACCAAAGTCAACAATAAAAGTTTTGACACCAAAAGTTGTACCAAAAATAGAGGAAACTGAAACGAAAAAACCGGAAAAACCTGCTGTACTTTCACCTACAATTTCGTCTCCTAAGCCTGTTATAAAGGATTCAGAAATTATCAGATTATTAAACAGTGAACCAAAATCCAAAACAATTGATTCCATCTTTGATACAGTTACTTCTAAAACAAATGATACCCTACATAAACAAACTGAAGAAACGTCAACAATTCAGCCATTAACAGTTGATAAATATCCAGAAATAAAACTTAAAGACCTTCTACATAAAGCAGAACCAATTCCAATCAAAAAAGATGATCATCGGCCAACAGGAATAAAAACTCTTCTTCCAGTTGTTCGACCACATGTTGAAGAAGAACTAGAAGATCCTGAAATAAGTTTGAAACATCACGCGATTTCGAAAGTTGTTGAGAAATTAAAACCAACTAGAAAACGACAATCTTCTGATAACAGTGAAGCAATGAAGAGAAGAAGACAATCTTTTAAATATGATACTGATGACATGTCAGACTTCTTTGATGGCGACAGTCAATCACAAGAATCATTCAAAGATAAGAAACCAGTTGACTTACAACCTGTTGCTACAGTTGCCGAATCTCCACAAGTTATTATTGAAGAAGGCGAGGTTATTCGCTTAGTTCACATGCGAAGTGAAGAAATAATCAATTGCACTTGTGGAATAACAGAAGAAGATGGACTTATGATCCAGTGTGAATTATGTTTATGTTGGCAACATGCTCATTGTAACAATATCCAGCGAGAAAACGAAGTTCCCGATAAATACGTGTGTTACATCTGTAGAAATCCTCAAAGAATGCGTGCTTCGAAGAAATATATTCACGATCAAGAATGGTTGAAGCAAGGAGTTCTTCCAACAGCAAGTTTCCACTCCAAAGACGAACCAGCACTTAAGCAAAAATTTGAGAAGTTGAGAAAATCCCATGAACTTAGCGGATGTATCATCGAAATGAATGAATATATTCATAATCTTAGAGTCAAACTCAACGTTGCAGAAAATAAAGATCATCCAAAGTTATATTTGTGGAACAAATCTTGGGAAAAGCCGATGCCACACGAAAATTTAAATGCAATGCTGTCAAAATCAGATATCAAACAAGATGTTAAAGAAGAAAATTTCAACTCTAGTTTTTCAGGATCCGATCATAGTTACATTAAAACAAGCACTTTTGGTGATGTTGCTCTAAAAAGCTTGTTAGAACCACCTGTTGAGGAAATAAAAACTGAAGTAAAACATGATGACACTAAAATTAAATCCGAATCAGAATTACTTTCAATTCTTGAAGATAACGAAACTAGCCTAACTGAAAATCAGGATAAATCTGTACCAGAACCAGCAGAGTTCCCGAAAATTGATCTTAATTCAATGATTGCCAATAACCTCCCCGAAAAAATCGAATCCAAAGATGAAAATATCCCAGAAGACAATAAAGAAAATGCCTTAAGTTCTATTACTAGCGGTCTTTTAAGTTCTGGATCGCTGGAATTAGCGTTGTCACAAACAGATCTTGTTTCGTCATTTGCACAGTTAAATGAAGTTGAGCCTGTTCATATACCACAACCGGAAGCTGTTATTGATCCCTCCGATTGTAAAATGAACTTACTTGAACATGTTGCTCATTTCCAGAATTTAGTTGATGAAAGATTAAATTCCATTGAAGCAGAGATAAGTGAATTAGAAGACCAGGATTCGAATTTAGGTCCAGATGATGATGAAGACACTTATCCAAAAATAAAACAAACGTTACAAATGTTACTCAAAGATCTTACTACAATGCGACAAATAGCTGCATTAAGCAATTAA
Protein Sequence: MGRKCNVLDCPSDSRRPEDNGVTFHKMPFHPDLRPKWIELCRIPEERQINKVIYVCSRHFRRTDFCNFKGTKYMLRQGALPSVFPWTKSLIKSAQQTPKLAIPMEEDSENVEIKTEPLDEDEQPSIDDMADKLELETELPEEPEDEKPKIKKEPSTSVKKEPPIPIKKEPIDEILIPAPEIKTEPITFLPGSRIEASDFNEKWHPATILEVDYDENEVFVEFDKQLNKANEWIPMDSSRLRPFQPPSSVETYAVGEKVMATWVKTCSKFPATIRKVLDTDTYEVLFDDGFSKILKHHKIDKVSSAASSIQKAPLHHVSPLFDPVVGSKEERRERKRKLNVAELFGIGKISNKKYKSDDYFKSEPEDDVQSQEDFRSTGSSSQCEGEEWTCRWLNGEPVGIESELEGVDGPRRSIIVADHRLPPGWEKHLTQRLNGTYAGKWDAIIINPHGKRFAHRHMVKSWLEENKLDYNIDRFDFCLHLHRARKLGLYEVTDPEALAAAKATALAKRSATKGTKESSKSHSNKMSTPKSGSTINLPVTPESIEPEPIEEDTSGCLKIIHEDGSYKCPIDGCGKIFRKENLAQMHVKHYHPESAKLLGSTPNVADLAYARTVGEHIDDIIPKSRSVGSPLEKEKIIKTESTPKPKSTIKVLTPKVVPKIEETETKKPEKPAVLSPTISSPKPVIKDSEIIRLLNSEPKSKTIDSIFDTVTSKTNDTLHKQTEETSTIQPLTVDKYPEIKLKDLLHKAEPIPIKKDDHRPTGIKTLLPVVRPHVEEELEDPEISLKHHAISKVVEKLKPTRKRQSSDNSEAMKRRRQSFKYDTDDMSDFFDGDSQSQESFKDKKPVDLQPVATVAESPQVIIEEGEVIRLVHMRSEEIINCTCGITEEDGLMIQCELCLCWQHAHCNNIQRENEVPDKYVCYICRNPQRMRASKKYIHDQEWLKQGVLPTASFHSKDEPALKQKFEKLRKSHELSGCIIEMNEYIHNLRVKLNVAENKDHPKLYLWNKSWEKPMPHENLNAMLSKSDIKQDVKEENFNSSFSGSDHSYIKTSTFGDVALKSLLEPPVEEIKTEVKHDDTKIKSESELLSILEDNETSLTENQDKSVPEPAEFPKIDLNSMIANNLPEKIESKDENIPEDNKENALSSITSGLLSSGSLELALSQTDLVSSFAQLNEVEPVHIPQPEAVIDPSDCKMNLLEHVAHFQNLVDERLNSIEAEISELEDQDSNLGPDDDEDTYPKIKQTLQMLLKDLTTMRQIAALSN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01275370;
90% Identity: iTF_01275370;
80% Identity: iTF_01275370;