Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_014839585.1
Location
QVOB01014127.1:1-6588[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.1e-15 6.7e-12 45.2 0.4 8 69 402 463 396 471 0.91

Sequence Information

Coding Sequence
TGTATAGAATTATCAAAGTTGGAGCATTCTGCTTCACCATTATCGTCGGAAGCAAGAACACCTAAATCAGACAGTTGTGGCGAGACCTGTTACTCAAGACCGGAATCATCTGCAGACTCATTAACCAGCTTGGAAGTAGCAGATAACGAGTGTAAAATGACAACTCCAAAAGAAGAAATGAAAGACAAAACCGCTGAAAATTCTGATAGCAAATTGAACACGGTGGCGATGCAACTTGGTATTGTTGAGTCGGGACCAACAATGGAAACCAGTACCAAAGATCTAATGTTAAAGGAAGAATTGAAGACCATCGAATTGTGTCCGAACAACAAGGAGTTTCAAAAAACTGAGGAATTAAAACCAAAAGTTTTAAATTGCGGTGGATTAGACTTTTCGCCCGGTGCCAAATTGGAAGCAAAAGACTTCAATGAAAAATGGTATTCTGCAAAAGTAGTGGAAACAGATTGGGATGAAAGAGAAGTTTTAATACATTTTGACAAGTGGAGTTCAAGATTTGATGAGTGGATACCAATGGATAGTTCCAGACTTCGACCAGCAAACGACCAACTGTGGATCCTGCCATCTTTGGAAACGGAGTTTTTGGTGGGAGAAAGGATACTTGCTACATGGGCCGACGGTAGAAAATATCCAGCAAAAGTCCGTGCGATTTTGCCAAATGACAGATATAACGTGTTGTTCGATGATGGATACGAGAAGATCATCAAGTCATCAAAAATGGAAAAAATCACCGCAACCCCGATCAAGCAATTGAATGAAGCAGACGGATATATTGGTAGCAAACAAGAAAGAAGAGATAAGAAAAGGAAACACACAGTCATGGAATTGTTTCATTCAAGAAAACGTACAAAATCGGACAAAAGTAGTGCTGATAAGATACCAAAGAAAGAAGAGACTATTGTGAAAGAAAGTGAGGAAATTTATGTTGAAAACAAGATCAAAGTGGACGGCACGCTCTATGACGCTTGCTACGATCCAGGCACAGACTTATTAAGAGGCTTTGATGTGGCTACTCCTGCAAAACTTAAATCATACTCAAAAAAAAGCAAGAAAGAAACACCCAAACTTGATACAGATTTGGAAGAAGATGTCGGTCCTGAATGGATCGACGGAGAACCACAAGGAACAGAGTCTTATATTGTAGATGGTAACGATGGACTACCACGTCGATCTATAATAGTGCCAGACAGAAGACTACCTTTCGGTTGGGAAAAGCACTTCACTCAAAGAAAAACTGGTTCATCTGCTGGGAAGTGGGATGTCTTATTTATACATAAACAGACTGGGAAAAAATTCAGATCCAGAAATGACATCAGAGTATTTATGGAGAATCAAGGACAATATGACTTTGATTCTGAGAAATTCGATTTCTGTATACACCGCAGAAAACGGAATAATGTTCATCGCGTGAAACACGATGTTACACCAGAAGTACCAAAGAAAATAAAAACTTTACTACCTAAAACAAAACCACACACAGTGCCTACGTCCGAAAATATGTTACTTACTACAGTGACAAACAGTAGTATTGATAGTCCATTCAATACTTCTACTTCAACTCCTACAACCTCTGCCGACGGCGCGGTTTTCATCGGACTGTGTGGCGGACTTCGCGTGGAAATGGAAGACAATGCTTATAAGTGCCCCAAGGAAGGATGTAATAAAAACTTTCGGAAAGAAAATTTATTGCAAATGCATATTAAGCATTATCATCCTGAATATTCCAAATTCCTGGGATCTACGCCGAAAGTTGAAGACTTGGCTTACGCAAGAACAATTGGAGAATCCATAGAAGATATTATTCCAAAAAAATCGTCAACGTTCTTAGAGAAGATCAACAAATTCGGGAAGAAAAAATCTCTACCGGAAAAGTCATCGCCTGGTTTGTTGCAACAATCGACATTGAACACTGTACAACCGTCATCTCCATCGATATCACTTGCGCCCGAACTGGATGAGGAAATTGATCAGTCAGAAAAGTGCATTGATTTGCAAAAGGAAGATATGAAAATCGAGACAATGTCTTCAATATCGAATCATAGCATGGAGATAGATGAAGATATTGAAAAGAAAAGAGAAAATAACTGTGCGTTATCTCCTGGTACTTTGTTCGACATGAAAATCAAAGAGGAAAAACCGCAAGGTGGAATTAAAACATTGTTGCCTGTGAGGCCACCTGGATCATCGGAGATACAGAAATTTGACAAGGCAAAATCTCTGGATGAAACACCGCACATCGAACGTCCCAAGATGCAAAAGAGAAAGCAACTTCCTGAGCATGGCATGAACTTGCCAGCTAAGGGAAAGAAACGACACGGTATATCAGATCTTGTCGATAGCTTTGGTGATCTGGACGACAGTGCTATGGACGCCGAAGGACCTACCGCGCTTATGTACAGATATAGCAGGAGAAAATCCGACTCCAAGAGTGACGAAAATAGTCAAAATAGTCAACTAAATGATTCTCGCATTGAAAAAAGCGATCCCTTAAAAGGGGATGTAACCAAAACAGATATTAATAATGATACAGAAGAAAGCGAAGGAGTGATGATGATGATCAATGGCGAATTGGTCAAAGTAGAACAACTTCGGAAAGAGGAAATAATAAATTGTACATGTGGCTACATGGAAGAAGACGGCCTAATGATACAATGTGATCTTTGTCTCTGTTGGCAACACGGCCACTGTAATGCAATTGAAAGGGAAAGGGATTATGTAATAAATCAAAGGACTGCGACGCTGAAACGTTCCTACGATCTAGTTGCGGCACTTTTACAAATACAACGACTTCTTCATAGTCTGCGTGTCAAAATCAATGTGGCTCAAAAGAAAGATCATCCCAAATTGTATCTCTGGGCGAAGAACTGGGAGAAGACGGATTTACCAAAAATAGATATCGAACCGGTACCAATAATGGAAATAACAAAATCAACTGGCAGCGCTGACACGGGATCGGAGAGTGTACGACATACTGAGATAAAAACGGAAGTCAAGTCGTTTATAAAAGACGATCAAGATGAAAAATCAATTGCTTCGGATTCGGAATTAATGAAAATTTTGGAAGAGGACAGCACACATTCTGACGAATCTAAAAAGGAAGACTTGATGAGTTCGCAAGAGAGTCATATACTTTTAGACGCATTAACAAGCGGCACTTCTGACGCAAAAGAAAAGAACAACGTGCAAGATGTTACGTCAGACGTTAAAACGGAGAGCCTAGATTTATCAACCGAGAAAACCACAATCGATCCTACATCGGAGAAGCTTGACTCAGGACCGTTTAGTAATAGTATGCAACACGAGCCGAGTACAGCTAATGTAGAAAACGAAATTTCTACACCACTGCAACCTTTCATACCAGAGCCTGAGGCACCGATCGATCCAACTGAATGTCGAATGAGATTGTTGGAGCACATTGAACATTTTCAATGTCACATCGATTCTAAGTTGACGTCAATAGAAGCACAGATTTGTGCTCTGGAGGCAATGGATCCAGATGAATTTGAGTCAGATCCACAAGTTCAACCTCGTACCAAACAAACAGTTCAGATGTTACTTCGCGATTTGGGTACACTCAGAAAATTAGCAGCGTTATGCTGA
Protein Sequence
CIELSKLEHSASPLSSEARTPKSDSCGETCYSRPESSADSLTSLEVADNECKMTTPKEEMKDKTAENSDSKLNTVAMQLGIVESGPTMETSTKDLMLKEELKTIELCPNNKEFQKTEELKPKVLNCGGLDFSPGAKLEAKDFNEKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRPANDQLWILPSLETEFLVGERILATWADGRKYPAKVRAILPNDRYNVLFDDGYEKIIKSSKMEKITATPIKQLNEADGYIGSKQERRDKKRKHTVMELFHSRKRTKSDKSSADKIPKKEETIVKESEEIYVENKIKVDGTLYDACYDPGTDLLRGFDVATPAKLKSYSKKSKKETPKLDTDLEEDVGPEWIDGEPQGTESYIVDGNDGLPRRSIIVPDRRLPFGWEKHFTQRKTGSSAGKWDVLFIHKQTGKKFRSRNDIRVFMENQGQYDFDSEKFDFCIHRRKRNNVHRVKHDVTPEVPKKIKTLLPKTKPHTVPTSENMLLTTVTNSSIDSPFNTSTSTPTTSADGAVFIGLCGGLRVEMEDNAYKCPKEGCNKNFRKENLLQMHIKHYHPEYSKFLGSTPKVEDLAYARTIGESIEDIIPKKSSTFLEKINKFGKKKSLPEKSSPGLLQQSTLNTVQPSSPSISLAPELDEEIDQSEKCIDLQKEDMKIETMSSISNHSMEIDEDIEKKRENNCALSPGTLFDMKIKEEKPQGGIKTLLPVRPPGSSEIQKFDKAKSLDETPHIERPKMQKRKQLPEHGMNLPAKGKKRHGISDLVDSFGDLDDSAMDAEGPTALMYRYSRRKSDSKSDENSQNSQLNDSRIEKSDPLKGDVTKTDINNDTEESEGVMMMINGELVKVEQLRKEEIINCTCGYMEEDGLMIQCDLCLCWQHGHCNAIERERDYVINQRTATLKRSYDLVAALLQIQRLLHSLRVKINVAQKKDHPKLYLWAKNWEKTDLPKIDIEPVPIMEITKSTGSADTGSESVRHTEIKTEVKSFIKDDQDEKSIASDSELMKILEEDSTHSDESKKEDLMSSQESHILLDALTSGTSDAKEKNNVQDVTSDVKTESLDLSTEKTTIDPTSEKLDSGPFSNSMQHEPSTANVENEISTPLQPFIPEPEAPIDPTECRMRLLEHIEHFQCHIDSKLTSIEAQICALEAMDPDEFESDPQVQPRTKQTVQMLLRDLGTLRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
iTF_01268339;
80% Identity
-