Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0075 1.1e+02 4.7 0.0 19 45 133 159 125 163 0.79

2 6 0.0078 1.1e+02 4.6 0.0 27 49 172 194 168 197 0.91

3 6 0.37 5.2e+03 -0.7 0.3 22 44 195 217 191 223 0.74

4 6 0.00043 6 8.7 0.0 15 45 260 290 247 294 0.85

5 6 7e-05 1 11.2 0.0 27 48 303 324 301 327 0.89

6 6 0.089 1.3e+03 1.2 0.4 18 30 322 334 321 337 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0075	1.1e+02	4.7	0.0	19	45	133	159	125	163	0.79
2	6	0.0078	1.1e+02	4.6	0.0	27	49	172	194	168	197	0.91
3	6	0.37	5.2e+03	-0.7	0.3	22	44	195	217	191	223	0.74
4	6	0.00043	6	8.7	0.0	15	45	260	290	247	294	0.85
5	6	7e-05	1	11.2	0.0	27	48	303	324	301	327	0.89
6	6	0.089	1.3e+03	1.2	0.4	18	30	322	334	321	337	0.83

Coding Sequence: ATGGATCAATTTACAATATACGATCCTTTAGATAGCAACGACCAAAAATTCGGCGAGATCTATTGCAATTATCAAGGAAACCTAACGTTTCGTTGTGTCTTTTGTCCAATCAAACTGAAAGATGCATCGGAATTCATCATTCACTACATCGTTCACGTGAAGGAAGTTTTTGAAATCGAAAAAGAGGAGGAAAAGCAATCGTTTCTGTTGGAACCAGAAATTGATATCGATGAAACGCAATTTTATTCGACAGAAATTAAAAGCGAACATTCCTTCGACGAAGACGATAGAGTGATACAAAAAGAGGACCTTGAGAAAGTTCAGTCGGAATTTGATGATGGAAAGAGTCACGACTCTTACGGAACTGCCATTAAGACTAGTTTAAAAGAAAGTGATAAAAAATTCGACCAGCCAAATCGTTGCCATATCTGCTCTCAAGAATTTATCTTAAAATCAGCcttagatagacacatagaaaGTCATGGAATAggattttttcccactaaatttGAATGTGATATTTGTGGTTCGAAAGTAAAGTTAAAGAAGGATTTGCGAACGCATATGAGACGCAAGCACATTGAGGAGAAAGTGCCATGTTCCATTTGTGGTAAAGTGTTTTGTCGAAGGAATTACTTAAGCGAACACATGAAAACTCACGTGAAACCCGAAAATCGAACgttcaaatgtaaaatttgcaATAAAAGTTTTGTGACACAAAAAGACGTGGAAGTGCACGTCAAACGACACCAAACCGTTCATTCGAATCACGTTAAAAAagagagtgacaaaaagtttgaaaatccaGCCAATTGCCATATATGTGGTCAGCAGTTTATCGTGAAAAAAGCACTTGACAGGCATATAGAGAGTCACGGTATTGGAATCATTCCGCTGATATACGAATGTGATATTTGTGGTGCAAAGATTAAGCAGAAAAAAGATTTGCGCACTCACATGCAAAGGATACATAGTGGACACAAAGCTACTTGCGCCATATGTGGAAAACAATTCGCTAGA
Protein Sequence: MDQFTIYDPLDSNDQKFGEIYCNYQGNLTFRCVFCPIKLKDASEFIIHYIVHVKEVFEIEKEEEKQSFLLEPEIDIDETQFYSTEIKSEHSFDEDDRVIQKEDLEKVQSEFDDGKSHDSYGTAIKTSLKESDKKFDQPNRCHICSQEFILKSALDRHIESHGIGFFPTKFECDICGSKVKLKKDLRTHMRRKHIEEKVPCSICGKVFCRRNYLSEHMKTHVKPENRTFKCKICNKSFVTQKDVEVHVKRHQTVHSNHVKKESDKKFENPANCHICGQQFIVKKALDRHIESHGIGIIPLIYECDICGAKIKQKKDLRTHMQRIHSGHKATCAICGKQFAR

Sequence clustering based on sequence similarity using MMseqs2