Pvib002394.1
Basic Information
- Insect
- Pseudococcus viburni
- Gene Symbol
- -
- Assembly
- GCA_033439095.1
- Location
- JAVBJF010000016.1:1116688-1121200[+]
Transcription Factor Domain
- TF Family
- Homeobox
- Domain
- Homeobox
- PFAM
- PF00046
- TF Group
- Helix-turn-helix
- Description
- This entry represents the homeodomain (HD), a protein domain of approximately 60 residues that usually binds DNA. It is encoded by the homeobox sequence [7, 6, 8], which was first identified in a number of Drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates [1, 2], as well as plants [4], fungi [5] and some species of lower eukaryotes. Many members of this group are transcriptional regulators, some of which operate differential genetic programs along the anterior-posterior axis of animal bodies [3]. This domain folds into a globular structure with three α-helices connected by two short loops that harbour a hydrophobic core. The second and third form a helix-turn-helix (HTH) motif, which make intimate contacts with the DNA: while the first helix of this motif helps to stabilise the structure, the second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions, which occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. One particularity of the HTH motif in some of these proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the β-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 14 0.0051 1.3 9.4 0.1 4 47 17 64 14 70 0.89 2 14 0.7 1.8e+02 2.5 0.0 26 47 121 142 109 146 0.86 3 14 0.00046 0.12 12.7 0.0 4 49 154 199 152 202 0.92 4 14 1.6e-07 4e-05 23.8 0.4 2 55 247 301 246 303 0.92 5 14 2e-09 4.9e-07 29.9 0.1 8 53 318 363 314 367 0.95 6 14 1.2 2.9e+02 1.8 0.0 14 47 486 519 480 526 0.86 7 14 5.4e-05 0.014 15.7 0.0 4 50 589 635 586 636 0.88 8 14 5.8e-12 1.5e-09 38.0 0.2 7 53 657 703 655 705 0.95 9 14 3.6e-12 9.2e-10 38.7 0.9 7 53 766 812 764 815 0.95 10 14 2.6e-07 6.6e-05 23.1 0.3 11 48 862 899 858 902 0.95 11 14 4.9e-10 1.2e-07 31.8 0.2 8 53 924 969 918 971 0.94 12 14 9e-06 0.0023 18.2 0.0 7 52 1108 1153 1103 1154 0.92 13 14 7.6e-09 1.9e-06 28.0 0.3 2 52 1265 1315 1264 1321 0.90 14 14 9.9e-06 0.0025 18.0 0.4 9 54 1337 1381 1333 1384 0.86
Sequence Information
- Coding Sequence
- ATGCTTTTGAATTTGCAGTGTCAGACAAAAATTGTTCATAGCGCAGTTCGTATAACAATAACCAGAGATCAAGCACTCAGATTACAAAAACTCTACCACGAGAAACCCGCCGGCCAGAGAAAATTCACCGACAAAGAAATCCGCAGAAACGCTATTCGCCTGAAAATTCCAGCTGTGAAGATACGCTATTGGCTGGGAAAACGAAATGCCCTGGCCGATGAACCTAATCCGCCGCCATCTACAGCTACATCGTCAGCTCAGCCCATCGACATCGATAAACCGCGTTGTAAGCTATTCGCCGATCTGTCGTTTGAGAAAAAGGTCGCCCTGTTGAGGAAGACTCGTACGGCGACCAAATTTTCGGTTCGTCTGACCCAAGATATCTCGCGAGAATTCCAAATACCCGAAAGTCGGGTGCATAATTGGCTCAGGTATAAAATATATCGTAATTTGCATACGAAAAGATCGCTTACTGTTCAGGAATTGGCAGCTTTGAATGGTAAATTTGTCGAGTTCGATTATTTGGACGACGATACGGCCCTCGTTTTGGCTGATCGATTGAACGTTAGTACGTCTGTGATAAAAAGAGCTTTCCAGCGATGTAAGCCATTGTCGCAGAATGTTACACCGGTCATCGAAGTGAAGAAATTGAATCTGCCGGCCTCTGTGACCATTACGATGGTCCCTAAGGTTACTCCTGATACGGTTACTCCTGATACCTCCGCATCGAACGAGCCGAAAAAGAAGAAGATTTTTAAGGTCGAACAGAAGAATACGTTATTCGAAGCGTTTCGAGAGTCTCCCACTTTGACCAAACCAGATAAGGTAGCTGAGATCGCCGAAGCCACCGGATTGTCCACTATGCAGGTTACCAAATGGTTGAGCGTGTTTCGTGCCAAATGGGCGCAGAGTAACGAATCAGGCTTGAAGAAGGCATTGACTCGAGGCGTGAACTCGGACCAGTTGGTGGCGTTGGAGAAAGCCTACAGAGAAGACAGATTCTTGACCAGCTTCCAGTTGAACGAATTACCTAAAACGGTCAGTATGAGTAAGCAACCCATCCAGGGTTGGTTTTCTAATCGTCGCATTTACGAAATTCGTTCCAACGATAAAGATCTCGTCAACATTGGCCCGAAAACCGTCCCAACGAGCACAGATTTGAATCACATTACGATCCTGAAACCAGTCATAACCATATCTCAGTCAAAGGTACATCAGCAATCTTTAAAAGCTCAACCTGACGTAGAAAGCACcgacgaatttttcgaatcgtTGAGCAAAGAGCAAAAACTGCATTTAAAATCGGCCTGTAAAAATTACAACGTTTCTTATAAGAGATTATCGCGAGCTCTCGGCCTACCCCTCGACAAGGTCCAGCATTTCATCAGAAGTTATCGCCTacaacataatattttcagaacAAGTAATTTAGCGTTACCGGAACGCGTACAAAAAACATTACTCAACCAttacctgaaatttggtaaaatttcgacGAAAACCAGCGTCATATTGGCGAAACGTTTGAAAGTACGCCCGGAACAGATCATGGGTTGGAATAAACATCACACCAAACGACTCCTCCAAGTTGGGGGAATAGTCAAATCGCCACCGACGATTGCTGCCGAACCAGTCGAACCGATCGAAACCCCTGTCGAAGTCGAATCTGTCGAAAATGGCGAACAAGAGTCTGAGCCGTCGGCCGAAATTCCAGCTCCGGTCCGCAaatcgttttctcaaaaagattACGGCAATCGAGGTTCGCGTTATTTCGCCTCTGCGACCGCCAAAGCGGTGTTGttcgaagaatttaaaaaatcgcccACAGCAGCTTCCACCgatatcaaaaaaatcgccaaaatggTGAAATTGACCCCGATGCAGGTCCGCAAATGGCTCTACAATTACGGTAAATCCCTCAGCGAGCAGACCAAATCGAAAGTCGTGGCTTGTCTGAATAATCCGCAGATCAGCGACGAAGCTCGAGCCAGGCTGGAAACGGAATACAGAAAATGTTCGTATATGGAGGAATCGGATATGGAAAATTTGGCCCAGCAATTCGGCTTGACCAGGAGACAGGTAGCTAGCTGGTTTATCAACGCTCGTTATTACGAAGCTCTCGTCGGCCGATCTCCTGGCGACGAAAATTTAACTCGTGCTCAAACGCCGCCGAAGCCTAAACCTTCATTACCTCGTATCGCAGATGATTCCAGTAGCTCTGCTGGTACCAGCCGAACTCGTCGTCGTAGTTTACCGGACGAGTCGAGTCCGACCATCCagctgaattttctcaacttgaccATCAAACAGATGGAAATTTTGGTCACCGAATTCGAATCGAATCCTAATTTGAGCGACGAACGCGCCGCGAATATGGCCAAACGTATCAAAATCACCAAAGATCGTATCAAAGCGTGGTTCGAGAACCGTCGACAAGAGCTACAACTCCAATCTTCCGACGATGCGGAACTAGCGAAACAGAAAATACCTCCTATTAAAATCATCATgccgaaattttccaattccgaCGATCAAATGCCTACGATAGCTTCGCCTGACTCGAGCTCCAAGAAAGTCCCCGTTCAGCAGAACACTCTGTTCGAGGAATTCAAACGAAGCTCAAAATTGACCAGCGAACGATTGATTAAAATCAGCGCAGAAACCAACCTATCTGGCAAACAAATCTCAGCCTGGTTCAACTGGCTAAACTATAAATTGTCGACGATTCCGAAAGAAAGCCTCTCCGAAGAAAATCGTAACAAGTATTTATCTCTGCAGCAGATCGAAGAATTGGAAAGGTATTACGCCGAAAATCGATACGCCCACAGAGCCGCTCGCGAATCTCTCTCCATATCTTTGGACGTTCCTAAAAGCATCGTAAAATCGTGGTTCGCTAGCAGACGTTATTACGAAATATTATCTCAAAACGGAGCCATCGAAGACCGCAACTCGCCCGAATACACAAATTTTGCCGAAGCAGATCCTGGTCAAAGTGAAACCGTCATCGACTACGACTGGGAAGCTGATCCAGCTGCCGTCGATCCCCTCGAACAGAAATTCGACGTTCAGCCTCTCGAGGTCGATCCGTTATTGAATTCTTACTGCAGCGAAGAACCGATCCAAGCTGAAATGGACGTAAACTTTCAGCTCTCCGCGAATACCGCCTTCGACGAAGATTTGACCAGTCTGCCTTACACGCCTCGAGAACGCCTCGTTACGCCGCTGGGTGACAATTTAGAACCGTCGGAAGAAAATGTCGAACGATTGTTCTGGTTCGTCAGCAAAACGCCCAACACAATTAACGAGAAATACAATCAAGAAATCGACGAAGCCAAGACCGCTATTCTAGATAGCGAATTTGGTAAATACCCGTGGCCCGATCTGGACCGAATTTCTCAGCTGTCAGCTCAATTGCTCGTATCGGAACCGAAAATCCATTGGTGGTTTATTAAAAAACGTTGTTTCCTGACTAAAACCATACTGACATTACCGGCGCCTACGGTTTCGAAACCGAAACCAGACCCTAAAAACGTGCTGATCGATTTAACCGACGACGATCATCCGGAGAAACCCGGAGAATTCGAATTCGTTACTTTGGACGAGACGACTCAGATCAAAAGAGAAGAAGAGCCGTTGAACGAAAATGACATTTTACAGAATGGCGACCCTTTCGAAAATAACGTCATCGAGAAATCATTCGACAACGAAGAACCGCCTTACGAGTCGAACGAATCGACTGAAAATGCCAACACTACTCCGAACTCTTCAGCCTCATCGTCggttaaaaagaaaaaagtcaaGATTCCGTTGACGTCTCATCAACGTGCCATTTTAATGCAAGAATATAAACGTAACAAGTTCATATCGAGTTCCCAGGCTCGTATCGTGGCTCAAGATTTAGGCCTGACCGCAActcgaattgaaaattggttCGAGTCTATGAGAAAATCAGCCGCGAAGAAGAAGGCTGGTCTTACGGAGGCCTCCGTTTCTGTCAAAAGTCTCAGTCCCGAGCTCGAATCTAGCCTCGAAGCGGAGTATTTGAAAAGTGCCAACTTGAGCGTCAAAAGAGCCAAAATGATTGCcctgaaattgaaaactaagAAGAAAACTGTCAAGAAGTGGTTCATCGAACGAGCCAAGCGAAAGGACGAGTAG
- Protein Sequence
- MLLNLQCQTKIVHSAVRITITRDQALRLQKLYHEKPAGQRKFTDKEIRRNAIRLKIPAVKIRYWLGKRNALADEPNPPPSTATSSAQPIDIDKPRCKLFADLSFEKKVALLRKTRTATKFSVRLTQDISREFQIPESRVHNWLRYKIYRNLHTKRSLTVQELAALNGKFVEFDYLDDDTALVLADRLNVSTSVIKRAFQRCKPLSQNVTPVIEVKKLNLPASVTITMVPKVTPDTVTPDTSASNEPKKKKIFKVEQKNTLFEAFRESPTLTKPDKVAEIAEATGLSTMQVTKWLSVFRAKWAQSNESGLKKALTRGVNSDQLVALEKAYREDRFLTSFQLNELPKTVSMSKQPIQGWFSNRRIYEIRSNDKDLVNIGPKTVPTSTDLNHITILKPVITISQSKVHQQSLKAQPDVESTDEFFESLSKEQKLHLKSACKNYNVSYKRLSRALGLPLDKVQHFIRSYRLQHNIFRTSNLALPERVQKTLLNHYLKFGKISTKTSVILAKRLKVRPEQIMGWNKHHTKRLLQVGGIVKSPPTIAAEPVEPIETPVEVESVENGEQESEPSAEIPAPVRKSFSQKDYGNRGSRYFASATAKAVLFEEFKKSPTAASTDIKKIAKMVKLTPMQVRKWLYNYGKSLSEQTKSKVVACLNNPQISDEARARLETEYRKCSYMEESDMENLAQQFGLTRRQVASWFINARYYEALVGRSPGDENLTRAQTPPKPKPSLPRIADDSSSSAGTSRTRRRSLPDESSPTIQLNFLNLTIKQMEILVTEFESNPNLSDERAANMAKRIKITKDRIKAWFENRRQELQLQSSDDAELAKQKIPPIKIIMPKFSNSDDQMPTIASPDSSSKKVPVQQNTLFEEFKRSSKLTSERLIKISAETNLSGKQISAWFNWLNYKLSTIPKESLSEENRNKYLSLQQIEELERYYAENRYAHRAARESLSISLDVPKSIVKSWFASRRYYEILSQNGAIEDRNSPEYTNFAEADPGQSETVIDYDWEADPAAVDPLEQKFDVQPLEVDPLLNSYCSEEPIQAEMDVNFQLSANTAFDEDLTSLPYTPRERLVTPLGDNLEPSEENVERLFWFVSKTPNTINEKYNQEIDEAKTAILDSEFGKYPWPDLDRISQLSAQLLVSEPKIHWWFIKKRCFLTKTILTLPAPTVSKPKPDPKNVLIDLTDDDHPEKPGEFEFVTLDETTQIKREEEPLNENDILQNGDPFENNVIEKSFDNEEPPYESNESTENANTTPNSSASSSVKKKKVKIPLTSHQRAILMQEYKRNKFISSSQARIVAQDLGLTATRIENWFESMRKSAAKKKAGLTEASVSVKSLSPELESSLEAEYLKSANLSVKRAKMIALKLKTKKKTVKKWFIERAKRKDE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -