Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.48 2.5e+02 3.0 0.1 58 90 126 158 107 165 0.87

2 3 6.9e-29 3.6e-26 92.6 1.8 2 109 168 274 167 275 0.94

3 3 0.25 1.3e+02 3.9 0.1 56 92 272 309 271 324 0.74

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.48	2.5e+02	3.0	0.1	58	90	126	158	107	165	0.87
2	3	6.9e-29	3.6e-26	92.6	1.8	2	109	168	274	167	275	0.94
3	3	0.25	1.3e+02	3.9	0.1	56	92	272	309	271	324	0.74

Coding Sequence: ATGTCGGCTCATAAAGTTGATAGTTGCTGTGTCTCTGAAATAAAACCAATTACTTCTCATTGGACTATAAATCCGTTTTTTCTGGAAgcttttacaaataaaaaatcaagTGAATTTTCTGGTCATGATACTGCCGGTAACCAGTTTAAATGGATACTGGAACTAACCATGAACGCACAATCTGGTTTTTGCATATTCATTCAATTGACGTCATCTTCTAAAAATCTGCATGCCTGGGTAAGCTGTtccattttaaataataaaggagAAAAAGATTATACCCAAAACACTGATAGTAAGGAACTCTTTGTTGGTGAACTTTCCACCTATAGTatggattttattaaaaaagatatattaatGAGAAGACGAAATATAATGGTGCCCGAAAATGTTTTGACAATATTGTGTGAAATTTATACTAGCGAAAGTGTCACCAACACTACGAAAGTGCCAAGTTTATTAAAAGCAAACACTGAACAAAACATAATGGATGATTATAGCAAACTCTTTGAAACGGAAAAACTTTGCAAAGTAACGCTAAAACTAAGTGATGGCATTGAAATTCAAGCTTATAAGGCCATATTAGCGGCTCGTAGTAATGTCTTTGCTGCCATGTTTGAGCATGAAATGATGGAGAATGAAGAAAACTGTGTAACCATAACAGATGTTGACAGTAATGTATGTAGAGAAATGTTGCATTTTATTTATACTGGCAAAGTACCCAACATTGAATCTATGGTGGAGCAACTCTTAGCTGTGGCAGACAAGTACAATTTAAACGACCTGAAGATGATGTGTGAAAATTATCTTATCTCAAATGTTTCAATAGACTATGCAGATTCAATACTAACTCTAGCTTATCGCCATAGAttggaaactttaaaaaagcATATACAATATTTGATTACAAGTACCAGAGATTTTATAAATTCCAACGCATTTAAAGACATGTTAACTAAGTATCCTGATTTATATATAGTTTTGAGAAACGgtgataataaataa
Protein Sequence: MSAHKVDSCCVSEIKPITSHWTINPFFLEAFTNKKSSEFSGHDTAGNQFKWILELTMNAQSGFCIFIQLTSSSKNLHAWVSCSILNNKGEKDYTQNTDSKELFVGELSTYSMDFIKKDILMRRRNIMVPENVLTILCEIYTSESVTNTTKVPSLLKANTEQNIMDDYSKLFETEKLCKVTLKLSDGIEIQAYKAILAARSNVFAAMFEHEMMENEENCVTITDVDSNVCREMLHFIYTGKVPNIESMVEQLLAVADKYNLNDLKMMCENYLISNVSIDYADSILTLAYRHRLETLKKHIQYLITSTRDFINSNAFKDMLTKYPDLYIVLRNGDNK

Sequence clustering based on sequence similarity using MMseqs2