Basic Information

Gene Symbol
-
Assembly
GCA_951394005.1
Location
OX596076.1:451885-455659[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.9e-13 2.2e-09 37.9 0.1 9 72 288 347 282 349 0.88

Sequence Information

Coding Sequence
ATGGAAGTAGACGATGCAATAGTTCAAGCAGAGCCTGTTGACGAAACAACTGTACTTGCTGGTGATGGTGGCGTAGGTGACGATGACATTGACGACAGAGAGCAGCAGACAACACCAAGTGCTTCTACGTCGTCATCGTCTAAGCAGAAACGTGCTAAAATTAAACACGATAAAGAAGAACCACCTGGTTTGTTGGAATCGCAAAATAATGACTCGGTTTTGACTGCTACCCCTTTTAAGTTAGAGGTATCGGGTTCAGAAGATGAAAAAGAAGATATGGAAGAAGGTGATAATGCCTCTAAAGTAGCAATTAGACGCAAATTATTATCAACTCCCATGGAGGAGGACTCAGCCGCCAAAGATGGTTTAGAAGAATTAGAGGAGGTGGCTATTAAAAGGAAACGCTATGAAGTAAGGAGATCTGGTTCTGAAGAGTGTTTACTGGGTTTTGATGAACTTAGCGGTGAAGCTGAATTGGTTAAAGCAGAAGTGACGGAAGAGCCTGTAGTATTAGCAGAAGAACAACCCATTGAGAGTGTTGAAGAACCTTTTAAGAGTGTAGAAATTGCTAATGAGGCTACTGAAAGTCCTTTAAATTCTCCCAAGCCCTCtaaaaagGCATCTCCTGTAACAAAAATTGCCTCGCCTGCTTTACAATCCACAAGATCGGCCTCAAAATCACCTAAAGCTCTAAAACCAAAAACACCACCTTTGGAGCCTCCTCAGCAATCTAAAACAGCTCAAAAATCTCCTCCCAAGCCTCATATAGTTGCTGATGGTGAGGAAATTAATGGCATGACACCTATAAAATCTAGTGCTACAACCAGGAAACCCATATCTCCGCAagatgaattttataaaaaaccatTTGAATATGGTTGGAAACGAGAATTGGTGTGGCGTGCCAATCCAGAGCAAAGTAAAGACAAAGCAGATGTCTACTTTATATCACCAGCTGGTAAAAAACTTAGGGCTCGTAGCGAAATTATACCATTGCTAGAGGGCGATTTGACCATCGATCATTTCTGCTTTACACGTGAGCCCTTAGGAGCTGGTCCTGAATTGGAAATTGTAAGAAGTGCTAAACCTTCTTCTAGAGCCTCAGTGCCAGCTGCTACATTGACTCCCGCTTCTGCTCCTCCCAGTATGGGAAAACGTGTTTCAAAACCGAAAGGTCCCAAAGGTGCAAGTCCTCCCCCACAAGGCTGGACCCCCAGCAAGGCTCTTAAAGTTAATAATGCTGCTTTATTAAGTAGTACTGGGGGAGTTGGAAGAGTTAGTGCAGCGCATCATTCAATACCAAGCACACCGCCCAGTAGTCGAAAACATGATATTTCTCATGGCAATGCAGCTCATTCCGCCAAGAATTCTAAAGCAAAAAaATCATCCATCAACAAAACAGAGGCGTCTTCAACGCCAGATGTTAAGAAAACAACTATAAATGTTGAATCTAAAGAACCTTGCACCGTAAATTGTCCAAAAGCTCAAGGACAAGTGCCACAACTTCAATGTACTAAATGTTTATGTCTACATCACCATGAATGTGTGGGTCTCAATCAATTCAACTCGGAATATCGAACCGCCAGCAATAGTCGTGGCAAGGAGTATATATGCGAGGCTTGTTTATCCAAGACACCAAATCAAATGTCTTCAACAGTTGCTAGCATGTCACCAGCAGTCTTAGTAAAGCCACCAGCAAATATGGTTAGCAATAAAAGACCAGAGAATAAATTTCCTCAGACTATTGCTGTGGTAAAAGGCAAGAAATACGTTATGGTGGCTAAACCTTTAGCACTGCCCAACGAACATGTcaatgatattgaaaatgatttgaaacAAATTAATGAGAGTATACGTAAAAATCGCAAACATTCAAACAATTCACTAGATGGTTCTGTACAGGCTCACAATTCTCATAATTCCATAGCGGTCGATCATTCGAATAAGTTATTTGCTACAAATTTCTTTGCCAATGTTTCATATGCTTATGATtcattgttgtgtattttaaaatatttaaaaatacatGAACGTCCTCGTGCTGCTGCAGTATGTAAATTATGGAATTTGGCTGCTAAGGATACATCACTTTGGCAAACTGTGCGTATGAAAAATTCAAAGGTTTGCAGTTGGTCTGGTTTTGCTGGAGCTTTGCGTCGTGGTGAAACTAAGCATTTGGATTTACGTAAAATGTTATTGCCTAGTGGACGTAGTGAGGATATGTGGAATGATTTCTGTGCAAATATAGGTACTGTGTGTTCTCTAGAAACCATAGATCTGTGTCGTTGCTCTGCCAGAGTTGTAGAGAGTTTATTCCAGAGCAACCGCAATTTGAAAGTAATCAACGCTTTGGCTATAAATGATGACACCATTAATCTAGAACACATTTCCCTGCTGCACTCCTTAGAAGAGCTACGTTTGCGTACTTGTGAAGCTGGAGTTTTGGCGGGAGATCTTACACCCATGGCTTCACTCTCTCAACTGACACATCTTTCTTTGACATCCATTAAAGGTTTGGGAGCTAAGAGTGTTGAGGTTTTAGGAGAATTGACAACCTTAAAATCCTTAGAATTGGGAGAATGTGGTGACTTTGATTCAACATTTGCCGAAGCTGTGTTAcccaaattaataaatttgcaaAGACTTCGTTTGGAAAACAGTCAAGTTACAAATGTGTGTACTTTGGAAATTCTTGATGCTGTGGCTAGATTGGTGCAATTAAATCAATTGGAATTGgttaattttgatataaaaccAGGGTTTGATGAGAAATTAAGTTTATGTATGAATATTAGCAAATTGCTCATCATTCCTACCTACATTTCTCAGTCGGCCACCACCAATCAAATTGTTCTCAGTGCCGTACAGCAAGTGTCTGAAACTCTTAAAGTATTCACCTGGTGTGTAACCGTTGAACTGCTCCGAGTTACAGCCCTCTATGTTGATCAGTGTGAAGAATCtacgaaaaaagaaaaacatcatTTCGATGAATGTATACCGGTATTGAAACCGGTACCGGGAGCCACCACCGGCGATGAAGATGAAGAGGAAACCGCTAAAGCTAAATCGCCCGCAGTCAAAACAGAGGACAGTTCTACTGCGACGGAAGTTCcccaaattgaaattttacctTTGGATAAAGTAGAATCTATATTAGCGGAAAATTTACCCAACACCAAGTTTACCATTGTCAAGGTGCCCTACCATGCGACTTGTAAACAACAATTAGTGGAGTTAAattag
Protein Sequence
MEVDDAIVQAEPVDETTVLAGDGGVGDDDIDDREQQTTPSASTSSSSKQKRAKIKHDKEEPPGLLESQNNDSVLTATPFKLEVSGSEDEKEDMEEGDNASKVAIRRKLLSTPMEEDSAAKDGLEELEEVAIKRKRYEVRRSGSEECLLGFDELSGEAELVKAEVTEEPVVLAEEQPIESVEEPFKSVEIANEATESPLNSPKPSKKASPVTKIASPALQSTRSASKSPKALKPKTPPLEPPQQSKTAQKSPPKPHIVADGEEINGMTPIKSSATTRKPISPQDEFYKKPFEYGWKRELVWRANPEQSKDKADVYFISPAGKKLRARSEIIPLLEGDLTIDHFCFTREPLGAGPELEIVRSAKPSSRASVPAATLTPASAPPSMGKRVSKPKGPKGASPPPQGWTPSKALKVNNAALLSSTGGVGRVSAAHHSIPSTPPSSRKHDISHGNAAHSAKNSKAKKSSINKTEASSTPDVKKTTINVESKEPCTVNCPKAQGQVPQLQCTKCLCLHHHECVGLNQFNSEYRTASNSRGKEYICEACLSKTPNQMSSTVASMSPAVLVKPPANMVSNKRPENKFPQTIAVVKGKKYVMVAKPLALPNEHVNDIENDLKQINESIRKNRKHSNNSLDGSVQAHNSHNSIAVDHSNKLFATNFFANVSYAYDSLLCILKYLKIHERPRAAAVCKLWNLAAKDTSLWQTVRMKNSKVCSWSGFAGALRRGETKHLDLRKMLLPSGRSEDMWNDFCANIGTVCSLETIDLCRCSARVVESLFQSNRNLKVINALAINDDTINLEHISLLHSLEELRLRTCEAGVLAGDLTPMASLSQLTHLSLTSIKGLGAKSVEVLGELTTLKSLELGECGDFDSTFAEAVLPKLINLQRLRLENSQVTNVCTLEILDAVARLVQLNQLELVNFDIKPGFDEKLSLCMNISKLLIIPTYISQSATTNQIVLSAVQQVSETLKVFTWCVTVELLRVTALYVDQCEESTKKEKHHFDECIPVLKPVPGATTGDEDEEETAKAKSPAVKTEDSSTATEVPQIEILPLDKVESILAENLPNTKFTIVKVPYHATCKQQLVELN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2