Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.2 1.2e+02 3.9 0.2 18 44 7 33 4 38 0.77

2 7 0.0032 1.9 9.7 0.0 21 44 38 61 34 66 0.90

3 7 0.023 14 6.9 0.1 21 44 66 89 63 96 0.87

4 7 1.1 6.3e+02 1.5 0.1 24 46 124 146 118 152 0.76

5 7 0.29 1.7e+02 3.4 0.0 17 43 145 171 141 176 0.78

6 7 0.0003 0.18 12.9 0.0 21 47 177 203 159 208 0.84

7 7 0.15 88 4.3 0.1 21 51 205 235 202 237 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.2	1.2e+02	3.9	0.2	18	44	7	33	4	38	0.77
2	7	0.0032	1.9	9.7	0.0	21	44	38	61	34	66	0.90
3	7	0.023	14	6.9	0.1	21	44	66	89	63	96	0.87
4	7	1.1	6.3e+02	1.5	0.1	24	46	124	146	118	152	0.76
5	7	0.29	1.7e+02	3.4	0.0	17	43	145	171	141	176	0.78
6	7	0.0003	0.18	12.9	0.0	21	47	177	203	159	208	0.84
7	7	0.15	88	4.3	0.1	21	51	205	235	202	237	0.86

Coding Sequence: ATGAACCTGCACAAGCTGAggcacaccaacgagaagcgTTTCACTTGTGCTCTTTGCGAATACAAATGCCTGAAAGCGTCAGAACTAAAACGGCACATGTTAACGCACAACAACGAAATGCCGTACGCCTGCGAAGTTTGCAATAAGAAGTTCACACAACTCGGAAACCTGAGGCGTCACACGTTGGTgcacaccggcgaaaagccgttcggttgcgatctttgcgattacaggtGTCGCGACAATCGAATGTTGAGACAGCACACGCTGATACACACCGGAAAGTCGCTGAGatgcgacctttgcgattacgAAACCACGCGCTCCCACTACCTGAATCTGCACAAGTTAAAACATGCCGACGAGAAGCGGTTCGGCTGTACGCTTTGCGAATACAAATGCCTCGAATCGTCGCAGTTAAAACGGCACATGTCAACACACaacgacgagaagccgttcgcctGCGAAATCTGCGCTAAGAAATTCAAAAGCCTGGAAGGTTTGAGAGGCCACAAGTTGATACACGACGACGAAAAGTCGTTCGCCTGTGGAATCTGTCGCAATGCATTCAGACAAGTCGGAAGCTTGAGGCGTCACATGTTGATgcacaccggcgaaaagccgTTCGGCTGCGATCTCTGTGATTACAAGTGTCGAGAGAAGACAAGGTTAAAGCAGCACGTGTTAAGAAAGCACGCTGGAAAGTCGTCAACACAAACTGATGGACACCACGTCGAAACATTTATATAA
Protein Sequence: MNLHKLRHTNEKRFTCALCEYKCLKASELKRHMLTHNNEMPYACEVCNKKFTQLGNLRRHTLVHTGEKPFGCDLCDYRCRDNRMLRQHTLIHTGKSLRCDLCDYETTRSHYLNLHKLKHADEKRFGCTLCEYKCLESSQLKRHMSTHNDEKPFACEICAKKFKSLEGLRGHKLIHDDEKSFACGICRNAFRQVGSLRRHMLMHTGEKPFGCDLCDYKCREKTRLKQHVLRKHAGKSSTQTDGHHVETFI

Sequence clustering based on sequence similarity using MMseqs2