Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.018 11 7.2 0.1 26 49 116 139 110 142 0.86

2 6 0.17 1e+02 4.1 0.0 21 44 139 162 135 171 0.89

3 6 0.79 4.7e+02 2.0 0.1 25 45 171 191 165 195 0.85

4 6 0.012 7.3 7.8 0.1 21 46 195 220 192 223 0.91

5 6 0.04 24 6.1 0.3 21 47 223 249 219 254 0.84

6 6 0.00011 0.067 14.3 0.1 23 51 253 280 249 282 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.018	11	7.2	0.1	26	49	116	139	110	142	0.86
2	6	0.17	1e+02	4.1	0.0	21	44	139	162	135	171	0.89
3	6	0.79	4.7e+02	2.0	0.1	25	45	171	191	165	195	0.85
4	6	0.012	7.3	7.8	0.1	21	46	195	220	192	223	0.91
5	6	0.04	24	6.1	0.3	21	47	223	249	219	254	0.84
6	6	0.00011	0.067	14.3	0.1	23	51	253	280	249	282	0.90

Coding Sequence: ATGTCTTCGGAGGAAGTCCTGGTGCAAATCGCAGAGCCCGTAGTGGAAATGCTGGAAGAAAATTACACGTTGCTTCCCTACATCAAAGTGGATGATGAGGGGCTTATGGTTTTGAACGAGGAGATTTATGAGGAGCCAGGCAGCGATGAGCAAGTGCTTTGTGTCCCCATCGCCGAGACACTATTTGACTGTAGCATTGAGGGTGATATAATCGAGGAACAGGTGGAATCAGGCGGTTTCCTCAGTGAACATAACTATCATACTATTTCCAGTGGAGAGAACCAGTTGGATATGTATCTTGAGGATGTGCTCAGCAGGGATAGTCTCATTGCTAGTTCGAAACTGCAGTGTCCCTTGTGTATGAAGGTGTTGAAGGCGACTGATGCTTTCTATCGACATTTGAGGATTCATTCGGGGGAAAAACCATATCAATGTGAGCTTTGTGATAAGAAGTTTTCACAGCAGAGTAATTTGTGGAAGCACATCCTTATACACACAGGAGAAAGAAGATTTGAATGTCCCCAGTGCGCCAAGAAATTCTCTCAGAGAGCCAACATGCAAAAGCACATGATGGTTCATACCGGCGAAAAACCTTTCGAATGCTACATTTGCTCGAGGTTGTTCACTCAAAGAGCGAACTTGAACAAACACATTAGAATACACACAGGAGAGAAACCTTACACTTGTAAATACTGCAGCAGACAATTTGCACAACAATCGAACATGCAGAAGCACGAACTTCTTCACAAAGGCCTTAAACCGTTTGCGTGTGGAATTTGTTCGGCTGCCTTCGCTCAGCAGAGCAACCTGAAGAAGCATCTCGTGACGCACTTCAACAAAGAGAGGACCCACAAGTCCATCGCAACACGTGATTTGTCTAAGTCATATTCTGTAGTTTGTGAAAACCCTTATACCAAAACTGGGTTTTTTCACGGACAAGTAAAAGACTGTATAGTTGAACCGGGAACGTTCCTAGACACATTTGGCACTGGTAGAAACCAAGTCTACTTTGATTCGTCCAGCAACGTGAAAATCGAGATCGAGGTCGAACCAAAGAGATCATTTTAA
Protein Sequence: MSSEEVLVQIAEPVVEMLEENYTLLPYIKVDDEGLMVLNEEIYEEPGSDEQVLCVPIAETLFDCSIEGDIIEEQVESGGFLSEHNYHTISSGENQLDMYLEDVLSRDSLIASSKLQCPLCMKVLKATDAFYRHLRIHSGEKPYQCELCDKKFSQQSNLWKHILIHTGERRFECPQCAKKFSQRANMQKHMMVHTGEKPFECYICSRLFTQRANLNKHIRIHTGEKPYTCKYCSRQFAQQSNMQKHELLHKGLKPFACGICSAAFAQQSNLKKHLVTHFNKERTHKSIATRDLSKSYSVVCENPYTKTGFFHGQVKDCIVEPGTFLDTFGTGRNQVYFDSSSNVKIEIEVEPKRSF

Sequence clustering based on sequence similarity using MMseqs2