Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 4.1 2.4e+03 -0.3 0.2 20 44 9 33 4 37 0.78

2 10 0.0028 1.7 9.8 0.2 17 44 34 61 29 66 0.87

3 10 0.25 1.5e+02 3.6 0.0 21 48 66 93 63 97 0.85

4 10 0.07 42 5.3 0.0 21 41 94 111 92 119 0.76

5 10 1.7 9.9e+02 0.9 0.0 21 44 147 170 143 177 0.82

6 10 0.044 26 6.0 0.3 7 45 188 226 185 234 0.80

7 10 0.56 3.3e+02 2.4 0.0 21 43 230 252 227 257 0.85

8 10 0.015 9.1 7.4 0.1 21 44 258 281 255 289 0.86

9 10 0.029 17 6.6 0.1 21 48 286 312 283 314 0.90

10 10 0.00083 0.49 11.5 1.6 17 49 310 341 309 345 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	4.1	2.4e+03	-0.3	0.2	20	44	9	33	4	37	0.78
2	10	0.0028	1.7	9.8	0.2	17	44	34	61	29	66	0.87
3	10	0.25	1.5e+02	3.6	0.0	21	48	66	93	63	97	0.85
4	10	0.07	42	5.3	0.0	21	41	94	111	92	119	0.76
5	10	1.7	9.9e+02	0.9	0.0	21	44	147	170	143	177	0.82
6	10	0.044	26	6.0	0.3	7	45	188	226	185	234	0.80
7	10	0.56	3.3e+02	2.4	0.0	21	43	230	252	227	257	0.85
8	10	0.015	9.1	7.4	0.1	21	44	258	281	255	289	0.86
9	10	0.029	17	6.6	0.1	21	48	286	312	283	314	0.90
10	10	0.00083	0.49	11.5	1.6	17	49	310	341	309	345	0.89

Coding Sequence: ATGTGGCGACACAAGTTAAGGCACACCGAGGAGAAGCGGTTCAGTTGTACTCTTTGCCAATACAAGTGTCTCGAAGCAGCGCAATTAAAACGGCACATGTCAACACACAACGACGAAAAGCCGTTCATCTGTGAAATTTGCAATATGAAGTTCAGGCGACAAGAGACTCTGAGGCATCACTTGTTGACGCACACCGGTGAGAAGCCATTCAGTTGCGATGTTTGCGATTACAGGAGCCGAAAACACGAAACCTTGAAACAGCACATGATGATACACAACGACGAAAAGCCGTTCACGTGCGGAATTTGCGGTAAGAAGGTCAGACGCTTGAGACCCCACATGTTAACACACACCGTCGACAAGCTATTCGgttgcgatctctgcgattacaagtgtcgAGCGAACTCGTTGTTGAAACAGCACGCTttaacgcacaccggcgagaagccgttcagttgcgatctctgcgattacaaggGTCGAGACAGGACAAAGCTGAAACACCACATGTTAATCCACACCGGAAAATCGTTGAGCTGTGACgtctgcgattacaagtgtGAATTTCCCGACGGTATGGAGAGGCACAAGTTAAGACATACCAACGAGAAGCGGTTCCATTGTACTCTTTGCGAATACAAATGTCTCAGAGCGATACAATTAAAACGGCACATGTTAACACACACCAACGAAAAGCCGTTCGCCTGTGAGATTTGCGATAAGAAATTCAAACGTGTCGGATACCTGAATCGTCACGCGTTAACACACAGCGGGGAGAGGCCCTTCACTTGCGATTTCTGCGATTACACGTGTCGAGAGAGCTTCAGGTTGAAACAGCACATGCTAACACACACCGGAGAGAAGCCGTTCGGCTGCGATCTTTGTGATTACACGTGTCGAAATAGCACGAAGTTGAAACAGCATAGGTTGAGACACACCGGGgaaaagccgttcagttgcgatctttgcgattacaaatgccgacagcACCAAAGTTTGAAACGGCACGTCTTAAGGCACGCCGGAAGGTCAACGACGCACTCTACCGACCACGCGGAAGCAATTAATTTGTAA
Protein Sequence: MWRHKLRHTEEKRFSCTLCQYKCLEAAQLKRHMSTHNDEKPFICEICNMKFRRQETLRHHLLTHTGEKPFSCDVCDYRSRKHETLKQHMMIHNDEKPFTCGICGKKVRRLRPHMLTHTVDKLFGCDLCDYKCRANSLLKQHALTHTGEKPFSCDLCDYKGRDRTKLKHHMLIHTGKSLSCDVCDYKCEFPDGMERHKLRHTNEKRFHCTLCEYKCLRAIQLKRHMLTHTNEKPFACEICDKKFKRVGYLNRHALTHSGERPFTCDFCDYTCRESFRLKQHMLTHTGEKPFGCDLCDYTCRNSTKLKQHRLRHTGEKPFSCDLCDYKCRQHQSLKRHVLRHAGRSTTHSTDHAEAINL

Sequence clustering based on sequence similarity using MMseqs2