Basic Information

Gene Symbol
-
Assembly
GCA_036172665.1
Location
CM069870.1:22346220-22359874[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 21 0.012 0.77 11.3 1.0 2 23 187 209 186 209 0.96
2 21 1.1 71 5.1 0.6 1 19 345 363 345 366 0.89
3 21 5.8 3.6e+02 2.9 0.1 6 20 428 442 426 444 0.92
4 21 1.7 1.1e+02 4.5 3.6 1 19 450 468 450 473 0.91
5 21 1.8e-05 0.0011 20.2 1.0 3 23 543 563 541 563 0.96
6 21 1.9e-05 0.0012 20.1 1.6 3 23 579 599 577 599 0.97
7 21 1.4 90 4.8 0.1 2 23 607 629 606 629 0.92
8 21 0.0041 0.26 12.8 0.1 2 23 634 655 634 655 0.96
9 21 0.00013 0.0081 17.5 0.1 2 23 678 699 677 699 0.97
10 21 0.028 1.7 10.2 3.3 1 23 720 742 720 743 0.95
11 21 0.022 1.4 10.5 0.9 1 23 754 776 754 776 0.98
12 21 2.4e-05 0.0015 19.8 8.7 1 23 802 824 802 824 0.98
13 21 3.4 2.1e+02 3.6 3.8 3 23 846 866 844 866 0.96
14 21 0.0032 0.2 13.1 0.6 1 23 893 915 893 915 0.97
15 21 0.072 4.5 8.9 0.0 2 23 930 952 929 952 0.95
16 21 0.00059 0.037 15.4 0.5 1 23 969 991 969 991 0.95
17 21 4.2 2.6e+02 3.3 0.2 1 23 1029 1052 1029 1052 0.93
18 21 0.0057 0.35 12.3 0.5 2 23 1063 1084 1063 1084 0.97
19 21 2.2e-06 0.00014 23.0 1.3 1 23 1093 1116 1093 1116 0.97
20 21 0.00012 0.0078 17.6 2.2 1 23 1124 1146 1124 1146 0.98
21 21 0.00097 0.061 14.8 0.4 1 23 1164 1187 1164 1187 0.98

Sequence Information

Coding Sequence
ATGGCAGAAGGAAGATCTGCAAATTACAGTTCCTGTTGCCGACTCTGCTTGTCGGATAAGTACAATACATTGAAGCCAATATTTGAAGATGAAGCGGATAGTCGGGCATTGTCCCAAAAGATCTTGCACTTCCTGGGAGTTGAGGTGTCCACCAATGACAAATTATCCACCCTGATATGTACTGAGTGTTTAAACCAAGTCAACAATTGGGATAGTTTCAAGAAGGAATGCTCAGAAAACCAAATCAAACTTCAAGAGTGGATAAGTCTTTGGACCACAAGTGGATCTGATTTAGGGAACATGAGCATACAAATTAAAGACGAACCAGTCGACCATGAGGAGCACCAAAGATTGGAGAATGGTGATGTGAATAATTCAGAACAATCCGTTGTCATCAAATCAGAACCCATCGTCGAAATAGAAGAATTCTATGAGAATCCTCCCCCTTTAACTCCGCATCCCCCTGACATCTTAATAGAGGGTGATGAGGAATTAAGTTTAGAagAGTTTCATATCAATGGAAATGGCGATGGCAGCACCAGGAGGAAGGATGGTAAGCAGTGTTCTTTTTGCAGTAAAGAATTTAGTACAGTTGGTAATCGCATGAAGCACGAAAGAATTATACACAGCAATAAACGGAAGTCAGCTCATCATGCAAGCGATTCAGTGACTTCTAATCAAGACGATTCATCACAGCATTCTATGGAATCTCTAGCTAGCAGTTCGGCCATTACAGAAGCGTCCACGGTGCCCCACGATTCGGAAAACGAACATTCCTCCACGGAGCGCGCGGAGACGGACATTCAAAAAATCCAGTTCGCAGCCGGCTTACACCTCAAGCAAACATCCGCGTCCTCAACAGACAAGTACATCGATGACCCCCTGTCTAAAATAGAGTTAGCTTACTTAGATAGGTGCAAAGCGATGGTGTCGATGTTGCACTCGTTCAAATGCTCCTGTCACAACGTCACCTTCCCGACAATCAAGCGATTATTCGCGCACCTCCGAATGTGTTACACGTGGTTCCCAATATTTACGTGTTACAATTGCGTAATAACGTTTTCCAACAGATCTCTCAGCATGAAACACACCGGTAAGTGTCCGAAGCAATACCTAGAAAACATTATGCGGATGGCAGAGCTACGAAAGCGAATGGAATCAAAGCAGCGCATATACCAGTACTGTAGGTGTGTGAAATGCGCAAACTTGTATTCGTTTTATGACGATTACTGCGACCACATCGACAAGGAGCACATGTCGGAGCCCCCGTACGTCTGCCTGTGTTCGAAAGAGTTCGGAAGCGCTGAAGAATACAAGCAACACCTGTacatatcatgttatttaagtTACTATTGTGATGTGTGCTATACCACGTTCGATAatataaacgattttaaaacgCACTGCGAGTCCACACATGATGTGGTCGAGGAGTACACGTTCGTTACCTTCGAGGCCTCCTTCAAGCTAGTGAATCACGAAGATATAATCGCGGCGAATAAAAAGCGTGTGTATGAAGAAGTGACTCCCCCGGATTTAGCCCCGGGGGAAGAAGACGGTAACGATAAGAAGAAGATAAACTTGGGGTCGGCGAGGGGGGTTGTGTATCATCAAGAGCCGGTGAACTGCGAGATATGTGACCGGAGATTCTCGAATTATTACACGCTGAAGAAACACTTGAAGGGGCACCGCAAGAATAATTTCAGCAACGGCTGGAAGAATAAGCCGTCGAATTGTGATAAGTGCGGCAAGGTGTTCTCGACATTCTATAACATGCTGCGGCATAAGAGGGTGCATGACGACTCGGAGAAGACTTTGCAGTGTGCTCTGTGCACTGACAGGTTTCGATTGGTTTCTCAACTAAAGGATCATTTAATACTTGTGCACGGGCAGGCGAATGTGTGTCAGGAATGTGGTAAACAGTTTGAGTCCGTGGAGGAACTCGATCAACACAGGAGCGTTCACTTGAATATTAAGGTGTATCGAGATTCGAAGACGGATTCATATCGAACGTCCGCACAACGATTACTAACTTGTGAGATTTGTGATCGCACTTTCGAGAGCGAAATGGacttaaacgaccacataatcAAACATGAGACCATGCCTGTGTTGGATGCGgaatgtgaaataaaagaaaggaaaccGTTTCACAAATTTTCTTGCCCCGACTGCGAGAGGCACTACGTTAGCTACAAGGGGTTATGGCTACACAATAAAAGGCACCACCCCGAAAGGAAAAAGGCTTCGCAGCAGCCTTACCAGTGCAGATACTGTGATAGGATCTTGCAGACCAACGCAGCTTATCAAATGCACAAGCAGATGCATGAACGGATGATGAAGCAGGGTTTCAGCGGACCTTCAACCGTCAAGAACGGTGgtgacgaagaagaagaatccTACCACACCTGCAAGCACTGCTTCAAAGTGTTTTCGAGCAAATACAATTTGAAGACACACCTGAAAACACACGGCATAAATATCTCCCCCGGCCGTGCTTATTCGAAGACGGGCAAGTTTGTCAAAACGTTCTGGTGCGACACCTGCCATCAAGCGTGCCAGGGCTTCAGCGAATTACAAAAACACAAGCAGGAGCACATCGATGAGAAAATGCAAGAGGCTGCGCCCGAGCTGGAAAACCAAGAGGAAGACGCCATCGAGCACAAGCCCCATCTCTTCCCGTGTGATATTTGTGCGACAGTGTTTACTTCTAAGTTCGCAGTGAAAAAGCACAAGGAGAAGCACGAGCTTGAAAGTCGGGGGCTGGGCACCAAGCACAAGTTCGTCTATTGCAAGTACTGTAAAATCCCATTCTTGGACGTGGACGCTCTGAACAATCACATGGAAGTAGAACACGAAGAAACCATGAAGGCccagaaaattaagaaagacaCCTCCAAGAAATTCATGTGCGATCTGTGCAAGAAGGTTTTCGATACGGCCGGTGCCCTCTGTTCGCATCAGGGCTGGCATAAGCGAGGCAAATCCGCAGACAAGACCTTAAAATCCCAGCAGAAACTCTTCAGGAAAATCGTTCACGACCTTCCCATTCCCAAACCCCCCTCCACCACCGGCGTCAATAAACACGAGTGCACCTCCTGCTCGTTGATGTTCTTAACCGACACTGCCCTTCAAATCCACATTTTAGAAGCGCATAGAAATATCAATGCAACCGTCGTACCTCCTCGCTGTACAATATGCAACTTAGATTTTAATACGCAGGAAGCCTACGAGAATCATTCCCGCCTACATAAAATGGTCGACAGTTCTAAAGCGTACCCCTGCAAGTACTGCTTCAAAGGTTTCAGCCGGAGCGACTCCCTGAATGCACACATAAGACAATTCCACAATGAATACCTGGAGACCTCCTTTAAATGCCGTCACTGTGATCGCATATTCGAGAAACAGAACGCCCTCACAATTCACTTGAAAGTCCACGAGAGACAGAAGGTGACCGGCTTGCCGGTTAAGCAGGCGAAAACCCACCTTTACTCCTGCTCCATCTGCCACTTAGGTTTCGACATACCCAAAGATCTTAGAAATCACATAATCACGTCGCATCCCTTTTAA
Protein Sequence
MAEGRSANYSSCCRLCLSDKYNTLKPIFEDEADSRALSQKILHFLGVEVSTNDKLSTLICTECLNQVNNWDSFKKECSENQIKLQEWISLWTTSGSDLGNMSIQIKDEPVDHEEHQRLENGDVNNSEQSVVIKSEPIVEIEEFYENPPPLTPHPPDILIEGDEELSLEEFHINGNGDGSTRRKDGKQCSFCSKEFSTVGNRMKHERIIHSNKRKSAHHASDSVTSNQDDSSQHSMESLASSSAITEASTVPHDSENEHSSTERAETDIQKIQFAAGLHLKQTSASSTDKYIDDPLSKIELAYLDRCKAMVSMLHSFKCSCHNVTFPTIKRLFAHLRMCYTWFPIFTCYNCVITFSNRSLSMKHTGKCPKQYLENIMRMAELRKRMESKQRIYQYCRCVKCANLYSFYDDYCDHIDKEHMSEPPYVCLCSKEFGSAEEYKQHLYISCYLSYYCDVCYTTFDNINDFKTHCESTHDVVEEYTFVTFEASFKLVNHEDIIAANKKRVYEEVTPPDLAPGEEDGNDKKKINLGSARGVVYHQEPVNCEICDRRFSNYYTLKKHLKGHRKNNFSNGWKNKPSNCDKCGKVFSTFYNMLRHKRVHDDSEKTLQCALCTDRFRLVSQLKDHLILVHGQANVCQECGKQFESVEELDQHRSVHLNIKVYRDSKTDSYRTSAQRLLTCEICDRTFESEMDLNDHIIKHETMPVLDAECEIKERKPFHKFSCPDCERHYVSYKGLWLHNKRHHPERKKASQQPYQCRYCDRILQTNAAYQMHKQMHERMMKQGFSGPSTVKNGGDEEEESYHTCKHCFKVFSSKYNLKTHLKTHGINISPGRAYSKTGKFVKTFWCDTCHQACQGFSELQKHKQEHIDEKMQEAAPELENQEEDAIEHKPHLFPCDICATVFTSKFAVKKHKEKHELESRGLGTKHKFVYCKYCKIPFLDVDALNNHMEVEHEETMKAQKIKKDTSKKFMCDLCKKVFDTAGALCSHQGWHKRGKSADKTLKSQQKLFRKIVHDLPIPKPPSTTGVNKHECTSCSLMFLTDTALQIHILEAHRNINATVVPPRCTICNLDFNTQEAYENHSRLHKMVDSSKAYPCKYCFKGFSRSDSLNAHIRQFHNEYLETSFKCRHCDRIFEKQNALTIHLKVHERQKVTGLPVKQAKTHLYSCSICHLGFDIPKDLRNHIITSHPF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00465234;
90% Identity
-
80% Identity
-