Paka012765.1
Basic Information
- Insect
- Propsilocerus akamusi
- Gene Symbol
- -
- Assembly
- GCA_018397935.1
- Location
- CM031471.1:2277409-2281110[-]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 9.2 7.5e+03 -3.2 0.2 43 77 122 157 112 161 0.52 2 4 0.28 2.3e+02 1.7 0.5 19 51 174 207 166 210 0.85 3 4 3.1e-09 2.5e-06 27.2 0.0 1 50 245 293 245 297 0.83 4 4 6.2 5e+03 -2.6 0.0 25 37 479 491 465 498 0.67
Sequence Information
- Coding Sequence
- ATGATTATTGGAGAAGTCGATCAACGATTGAGTAATAACTATTATGAAACACCCCCTCCACTGCATCAACAACCACAAGAAAAATTTGAAGTCCTTAAAAGGAAATTTTCTAGCGATAATGAAAATTTAAATAATTTCTCTGATCGATCGGCGACGGTTCAATATGAAAATCATCACCAACAAAAGTCCAATCACAAAATGCATTACACAGAAAGTGGATTAAATGAGAATTATCAAACGTATCAAACTGTAACAGAAATTCATCAAGATGGTAGTCAAAGTTTTATAAATCTTACTGTTATGACACCCACAACGACAATGGATCAATCAAATCATCAGCAACAAATGATTTATACAAGCAATTTCCATCAGCATCAGCAACGAGAAATAACGAAAACACCATCAATGGTTCGAGCTTATCAGCAGCAATCAGATAATGTTGAGGATAATGAAGACAAGAACTTATCGTGGCTATTCAATTTCAAATTGGATGATATTGCTAATTTATCGCCGGAAATTAAGAGAAAACGGACGAGCACAAATCACATTGAAAACCATCAGCAACACCATCAGAACTATTACAATGCATCAGTTCAACAACAAGCGCCACAAAATTCTATTTATGATGATGCAAATCAACGGAAGGAGCCGTGCATCGAAGATGATCTTAATGTAGCTGAAAATGTTGTCATAAGCACAAATTCATCATATCCTTCATCAAGTCACACTCCCAAAAAGCCACCCTTCACCTACACGGAACTGATTGAATATGCCTTAGAGGACAAGGGCGAGCTGACAGTATCCGGCATCTATCAGTGGATCTCTGATCGATTCCGCAACAAAGCAAAAGCTGGCGCTGGACACTTGTGGAAGATCTCGAGCCGTGAATCTGAAGCAAATTTCCTCGCATGGGAACATAAGAAACAGCGCCTTGAATTGTTTTTCAAAATGGAAGCGGCCAATAATTTGAAACACCAAAATGCCAATCGCACAGATTTGATGGAACTTAATGATCAGAAAGATCCAGAAAATATTGAAGCACAATCGTATGATGCTGAATTAAATGCAGCAACAGCATCAATTATCAGTTTACCACTTGATGCAACGACGCCAATTATTACGACACATGGTGATTCTGATTCTCCGATAAGCGGACAACAATTGTTTCAATATCACGAAATCCTGCCCGTCACTCATCAGCAATCAGATGATTTACGAAGGACAGCTGGTGAGATTCTCAGTGGCGTTCGTCGCAATGTTGAAGTTCAAATAATGCATCCAAATGAGCTTCAATCTTACTCGATTTTGAATTCCGAAGATTACCTGAATCCCATCTCAAAAGAAGAAATTATGCAAGAAAGCGGTTTGGGCTTTCGACGACATGACGAATTTTATCTAATTGATTCAGGCATTAATAGCACAAATGCTGATGAGGCAACAGAGATTTATGAAATTTTCCATGAGGATTTTAATCTCAATTATTTCGGCAACAACAATATCATTGCATGA
- Protein Sequence
- MIIGEVDQRLSNNYYETPPPLHQQPQEKFEVLKRKFSSDNENLNNFSDRSATVQYENHHQQKSNHKMHYTESGLNENYQTYQTVTEIHQDGSQSFINLTVMTPTTTMDQSNHQQQMIYTSNFHQHQQREITKTPSMVRAYQQQSDNVEDNEDKNLSWLFNFKLDDIANLSPEIKRKRTSTNHIENHQQHHQNYYNASVQQQAPQNSIYDDANQRKEPCIEDDLNVAENVVISTNSSYPSSSHTPKKPPFTYTELIEYALEDKGELTVSGIYQWISDRFRNKAKAGAGHLWKISSRESEANFLAWEHKKQRLELFFKMEAANNLKHQNANRTDLMELNDQKDPENIEAQSYDAELNAATASIISLPLDATTPIITTHGDSDSPISGQQLFQYHEILPVTHQQSDDLRRTAGEILSGVRRNVEVQIMHPNELQSYSILNSEDYLNPISKEEIMQESGLGFRRHDEFYLIDSGINSTNADEATEIYEIFHEDFNLNYFGNNNIIA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -