Basic Information

Gene Symbol
FOXL2
Assembly
GCA_018397935.1
Location
CM031468.1:7889187-7892469[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 4 3.2e+03 -2.0 0.1 5 17 10 22 6 60 0.58
2 5 7.9 6.4e+03 -2.9 0.0 18 31 50 63 47 77 0.74
3 5 8.7e-42 7e-39 131.5 0.1 1 88 107 193 107 193 0.97
4 5 0.18 1.5e+02 2.3 0.2 2 36 262 296 261 310 0.87
5 5 9.9 8e+03 -3.3 0.0 44 64 344 364 337 367 0.65

Sequence Information

Coding Sequence
ATGACGACAAAATTGAAGCAACATGAGACATCATATTCAAATATCATTAATATGGTACCGACATCATACGACGACTCATTGAAGACTCCATTAATCATTCCAGCGTCAGTGATTGAGCGCGAAAATGAAAAGTACAATAACAACAATAACAATAATAATGACATTACTTTGAGCAGCATTTCCAACACCAACAATTCGTCGCTAAAAGCCGAGGAGGTGTCGAATGAGACGAGCAATTTGATGATTGAAGATCGTCATAACAACACAGCATCCAGCACATCGACGGCATCAACAACAAATTCAGAGCGTAATGGAAATAGTAAACCGCCGTATAGTTATGTTGCTTTAATAGCAATGGCGATCGCTCACTCGCCAAATAAGCGTGCAACACTGAGTGAAATCTACAACTACATCACTCAACGATTCCCATATTTTGAGAAAAATAAAAAGGGCTGGCAGAATTCAATTCGTCACAATTTGAGTCTCAATGAATGTTTCATTAAAATTCCACGTGAAGGTGGTGGTGAGCGGAAAGGAAATTATTGGACTTTGGATCCACAATATGACGACATGTTTGAGAATGGAAATTATCGGCGTCGGCGCAGAATGAAGCGACCTTACCGCACTGGATCTCATCATTTCAATAAAATGTTTGGTGACGGATATTCCAATTTTGCTCGTGGTGTTTTCCCGCAGCCCACTTACCAAACATATCCACCTCGCTATGACACTGGACCTTGGATGCCACATAGCTCACAGTTGAGTTATAATAGCTGTTCGTCGCGTCCAAGCTATTCATATTCATCTCAACTACAACAGGCAACACAGTCTGTGCCACTGATAAACAATTCATACGGAACAATATCAAATAACATTACTGATTATTATCTTCCAACAGTGCCACAAAGTACCACTTCTCCTTCCATATCGTGTTCAGCCAATACCGTACGTCGCTTTGATGGCGGAAATCACACGAGTTTCTACAATTGGGATTCAGCATTATCGCTACAACCGGTTATTAAGGAAGAGCCTTCATCTGTTTCGGGATCAATTCAGAATGTTTCATCAACACAACAAAGCTACCAGAAATATGCATCTCAGCCATAA
Protein Sequence
MTTKLKQHETSYSNIINMVPTSYDDSLKTPLIIPASVIERENEKYNNNNNNNNDITLSSISNTNNSSLKAEEVSNETSNLMIEDRHNNTASSTSTASTTNSERNGNSKPPYSYVALIAMAIAHSPNKRATLSEIYNYITQRFPYFEKNKKGWQNSIRHNLSLNECFIKIPREGGGERKGNYWTLDPQYDDMFENGNYRRRRRMKRPYRTGSHHFNKMFGDGYSNFARGVFPQPTYQTYPPRYDTGPWMPHSSQLSYNSCSSRPSYSYSSQLQQATQSVPLINNSYGTISNNITDYYLPTVPQSTTSPSISCSANTVRRFDGGNHTSFYNWDSALSLQPVIKEEPSSVSGSIQNVSSTQQSYQKYASQP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-