Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_030444845.1
Location
JAUDTA010000012.1:4093343-4101248[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.5 3.2e+04 -3.9 0.0 45 60 411 426 410 441 0.76
2 2 7.2e-18 9.1e-14 52.3 0.3 8 69 555 616 549 624 0.92

Sequence Information

Coding Sequence
atGAAGCGGCGGCGTATACCGCGCTCGCGTGCCGTGGGGAGGGTATCGTCCGCTGTAACCGCGGCGGCATCGGCGGCGGGGGCGATGGGAATGGCGCGCAAATGCTGCGTGCGTAGCTGCGAGGCGGACGTGCGGGAGGCGCGCGCCAAAGGATTGCCGCTTCACAAGTTTCCCAAGGACGTCGCGCTGAGGGACAGGTGGTTGACCAGCGGCGGATTCGACGAGAGTTTCAAGCCGACGCCGGGCCAGGTCGTCTGCCATAGGCATTTCAAACGCGCCGACTACGACCACGCCGCACGGGGCGGTCACAAGTTCCTGCTCAAGAGGGGCAGCGTACCCTCGGTCTTCGCGGACTATGACAATCATCCCGATCCAGTGGTTATATCAGTGAAATCTTCTACATCTTATGCACAAGAAGACCTGGATCTGATCAACTCGGAAATACTAAATTTGGAACATTCTGCCTCGCCATTATTGTCAGAAGTGAGAACACCTAAATCCGATAGTTGTGGTGAAACGTGTTACTCCAGACCTGAATCGTCCACGGACTCTTTAAATCTCCCTGATAATTCAGAAGTGGATAACGAATGCAAAATGGCAAAGTTGAAGGAAGAAATTGTAGCATCGGTGAAAGACAAATTGGTTGAAAATTCAAACAGTAAAGTAAACACAGTAGCGATGCAGCTTGGTATTGTTGAGCCAGGAGTGACAATGAAGGCTGATGGtaaagatttaataataaaggaggaattaaaaaacattaagTTATCCGATGACAAGGAGTTTGATAAATCAGAGGAATTAAAACCAAAGTTAAATCGTGATGGCACAAAGTTTTCTCCTGGTGCTAAATTGGAAGCGAAAGACTTTAATGATAAGTGgtaTTCTGCAAAAGTGGTAGAAACGGATTGGGATGAAAGAGAAGTTTTGATACATTTTGACAAATGGAGTTCGAGATTTGACGAATGGATACCAATGGATAGCTCCAGACTTCGTGTATTGCAAACCCCATCACACGAACAAGCTTGGATCCCGCCATCTCCGGAGGCAAAGATGCGAGAGTTTTCAGTGGGCGAAAGGGTGCTCGCTATGTGGGCGGACGGTAGAAAGTATCCAGCCAAAGTTAACGCAGTCTTGACGAACGACAGGTACGATGTATTGTTTGATGATGGATATGCGAAAGTTGTCAAGTCCTCGAAAATGACCAAGATCGCCGAAAGTCCGACCAAGCAGTTGAGTGAATTGGAAGGGTATATAGGCAGCAAACAGGAAAGAAGAGATAAAAAACGGAAGCATACAGTTATGGAGTTGTTCAACACTCACTCGAGGAAACGTACGAAAAATGATGCCGACAAAGCACCAAAACGAGAGGAGACGGTTGTCAAGGAAAGTGCGGAAAGTTCTATAGAAAATAAGGTCGAATTAGATGGTACCTTATTTGGTGCCTGTTACGATCCAGGTACAGATTTATTAAGAGGCTTCGAGAGTAATCcctcaaaaattaaatcgtaTTCGAAGAAAAGTAAGAAGGAATTGcctaaaaatgaaaatacgGATCACGAAGAAGAGGTTGGTCCTGAATGGATTGATGGAGAACCGCAAGGAACAGAATCTTATATTGTAGATGGCAATGATGGACCACGTCGCTCTATAATAGTGCCAGATAGAAGATTACCTCCTGGTTGGGAAAAACATTTTACGCAAAGAAGAACTGGCACATCTGCTGGAAAGTGGGATGTTATATTCATACaTAAGCAGACTGGGAAGAAGTTCAGATCCAGAAATGACATCAGAGTATTCATGGAGAATCAAGGGCAATATGATTTTAATCCTGAAAATTTTGATTTCTGCATACATCGTAGAAAACGAAATCATGCGCAAAATCGCTCGAAACAAGAAGCTACAccagaaaaaaagattaaaacttTATTGCCTAAATCGAAAACATTGCCCACATCTGAGAATACATTACAAGTGACAAATAGTATCACTACAACACCTAACATCTCAACACCTGTTACATCTGCTACGGATGGTGCCGTTTTCATTGGACTTCGTGGTGGACTTCGTGTAGAAATGGAGGACAGCGCCTATAAATGTCCCAAGGAAGgctgcaataaaaattttcgaaaagaaaatttactgCAAATGCACATCAAGTATTATCATCCTGAATACTCCAAATTTCTGGGCTCTACTCCAAAAGTAGAAGATTTGGCTTATGCAAGGACGATCGGGGAATCCATAGATGATATTATTCCAAAGAAATCGCCGACATTCTTAgacaaaataaacaaatttgcTAAAAAGAAATCTCTTTCGGAAAAATCATCTACATTGCAACCAACATTGAATACTACGCAACCGTTGTCTCCTTCAATACCTGGCCCGATTATGCCGGAATTAGAAGAGGAAATGGATCAAATAGAGAAGTGCAATGATTTGCAGAAGGAGGATATGAAAATTGAAACATTGTCTTCAATATCTAATCACAGTATGGAGATAGATGACAAtatagagaagaaaaaagaacatACCTGTGCATTGTCTCCTGGTACATTATTTGACATGAAAGTTAAAGAAGAAAAGGCACAAGGTggaattaaaacattattaccTGTCAGGCCATCCACAACATCAGAGGTGCAAAAAAGCGATAGAGCAAAACCTTTAGATGAAATCACGCACGTTGAGCGTACGAAAAACCAAAAGAAGAGACAACTCTCCGAACACAGTGTAGATTTACTGACTAAAGGAAAGAAGCGACATgGTACATCGGATCTTACTGACAGTTTTGGTGATCTGGATGACAGTGCTATGGATGCCGAAGGACCTGCAGCACTTATGTACAGATATAGCCGTAGAAAATCCGATTCAAAGAGTGATGAGAACAGTCAAAACAGTCAACTAAATGATTCTCGTATTGATAAAGGCGATCCCTTAAAAGGGGATATAATCAAAacagatattaataatgatacaGAAGAGAGCGAAGGAGTGATGATGATGATCAATGGCGAAATGGTAAAGGTGGAACAACTTCGGAgggaagaaataataaattgtacatgTGGTTTTATGGAAGAAGATGGTCTAATGATACAGTGCGATCTTTGTCTCTGCTGGCAACACGGTCATTGCAATGCGATTGAAAAGGAGAAGGATGTTCCTGAAAAATACATATGTTATACATGTTTACATCCGTATCGGCAACGGCCATCTAAGAAATACTTTCACGATCAGGATTGGATTAAGGAAGGGAAATTGCCGagTTTGCCTAATCGAACTCGAAATCAGCATATAATAAATCAGAGAACTGCAATGTTGAAGCGTTCTTATGACTTGGTTGCTGCACTTTTACAAATACAACAACTTCTTCACAGCTTAcgtgtaaaaattaatgtggCGCAaaaaaaagatcaTCCCAAATTATATCTTTGGGCCAAGAATTGGGAAAAAATGGAAATACCAAAAATAGATATAGAACCAGTACCAGTAATGGAAATAGTGAAGGCAGAACCGAGTTTTACCGATGTGAGTTCGGAGATTTCACGACGAGCTGAGACGAAAACGGATGTCAAACTGCCTATAAAGGACGATCAAGATGAAAAATCAATCGCTTCGGATTCggaattaatgaaaattttggaAGAGGATAGCACGCATTCTGATGAATCTAGGATTATCAATAAAAGGGAAGGCTTCATGAATTCAAAGGATAGTCACATACTTTTGGACGCATTAACCAGCTCAGACATAAAGGAAAGAAACATCGCTATGTCAGATATTAAAACAGAAAACACAGATTTACTAGCTGATAAAACTATGAATGATAATTCTACATCTGGGAGTCTTTCTCTCAACTCGGGACCGCTTATTGATAATATTCAACAAGAATCAAGTATAGCCGACGAAGTCTCTGCTCTCCCGCAACCTTTTATACCAGAGCCCGAAGCGCCGATTGATTCAACCGAATGCCGAATGAGATTGTTGGAGCATATTGAACATTTTCAATGCCATCTTGATTCGAGATTAACATCTATAGAAGCGCAAATTTGTGCTCTAGAGGCAATGGATCCAGATGAACTCGCATCAGATCTAAATGTTCAGCCTCGTACTAAGCAAACTGTACAGATGCTCCTTCGTGACTTAAGCACGGTCCGGAAGCTGGCAGCATTATGTTGA
Protein Sequence
MKRRRIPRSRAVGRVSSAVTAAASAAGAMGMARKCCVRSCEADVREARAKGLPLHKFPKDVALRDRWLTSGGFDESFKPTPGQVVCHRHFKRADYDHAARGGHKFLLKRGSVPSVFADYDNHPDPVVISVKSSTSYAQEDLDLINSEILNLEHSASPLLSEVRTPKSDSCGETCYSRPESSTDSLNLPDNSEVDNECKMAKLKEEIVASVKDKLVENSNSKVNTVAMQLGIVEPGVTMKADGKDLIIKEELKNIKLSDDKEFDKSEELKPKLNRDGTKFSPGAKLEAKDFNDKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRVLQTPSHEQAWIPPSPEAKMREFSVGERVLAMWADGRKYPAKVNAVLTNDRYDVLFDDGYAKVVKSSKMTKIAESPTKQLSELEGYIGSKQERRDKKRKHTVMELFNTHSRKRTKNDADKAPKREETVVKESAESSIENKVELDGTLFGACYDPGTDLLRGFESNPSKIKSYSKKSKKELPKNENTDHEEEVGPEWIDGEPQGTESYIVDGNDGPRRSIIVPDRRLPPGWEKHFTQRRTGTSAGKWDVIFIHKQTGKKFRSRNDIRVFMENQGQYDFNPENFDFCIHRRKRNHAQNRSKQEATPEKKIKTLLPKSKTLPTSENTLQVTNSITTTPNISTPVTSATDGAVFIGLRGGLRVEMEDSAYKCPKEGCNKNFRKENLLQMHIKYYHPEYSKFLGSTPKVEDLAYARTIGESIDDIIPKKSPTFLDKINKFAKKKSLSEKSSTLQPTLNTTQPLSPSIPGPIMPELEEEMDQIEKCNDLQKEDMKIETLSSISNHSMEIDDNIEKKKEHTCALSPGTLFDMKVKEEKAQGGIKTLLPVRPSTTSEVQKSDRAKPLDEITHVERTKNQKKRQLSEHSVDLLTKGKKRHGTSDLTDSFGDLDDSAMDAEGPAALMYRYSRRKSDSKSDENSQNSQLNDSRIDKGDPLKGDIIKTDINNDTEESEGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPEKYICYTCLHPYRQRPSKKYFHDQDWIKEGKLPSLPNRTRNQHIINQRTAMLKRSYDLVAALLQIQQLLHSLRVKINVAQKKDHPKLYLWAKNWEKMEIPKIDIEPVPVMEIVKAEPSFTDVSSEISRRAETKTDVKLPIKDDQDEKSIASDSELMKILEEDSTHSDESRIINKREGFMNSKDSHILLDALTSSDIKERNIAMSDIKTENTDLLADKTMNDNSTSGSLSLNSGPLIDNIQQESSIADEVSALPQPFIPEPEAPIDSTECRMRLLEHIEHFQCHLDSRLTSIEAQICALEAMDPDELASDLNVQPRTKQTVQMLLRDLSTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00730116;
90% Identity
iTF_00867398;
80% Identity
iTF_01254851;