Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0004 11 8.8 0.2 20 50 52 82 43 84 0.78

2 6 3.3e-05 0.91 12.2 0.3 21 51 81 111 79 113 0.92

3 6 0.0014 38 7.0 0.0 21 45 138 162 130 168 0.91

4 6 4e-05 1.1 12.0 0.1 26 54 171 198 162 198 0.87

5 6 0.0051 1.4e+02 5.2 0.2 26 48 199 221 193 227 0.88

6 6 0.86 2.4e+04 -1.9 0.0 20 27 275 282 253 285 0.67

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0004	11	8.8	0.2	20	50	52	82	43	84	0.78
2	6	3.3e-05	0.91	12.2	0.3	21	51	81	111	79	113	0.92
3	6	0.0014	38	7.0	0.0	21	45	138	162	130	168	0.91
4	6	4e-05	1.1	12.0	0.1	26	54	171	198	162	198	0.87
5	6	0.0051	1.4e+02	5.2	0.2	26	48	199	221	193	227	0.88
6	6	0.86	2.4e+04	-1.9	0.0	20	27	275	282	253	285	0.67

Coding Sequence: ATGAGCCAAAACGGTGGTGCCATGAAAAGATCTGATTTCAAAGATGATGCCAGCAGTTCTCTAAGGGACAGCGGCATATCAATATCAGAAGGACTCTCTGAAAGTGAACCAGAAATCAACGAAAATGCATCTCAGAATAAAAAGATACGAAAAAATGCAGCTCGAAGTAAGGAATGTCACATCTGTATAAGAACATTCAAAAATGGTACTGACTTACGGCGTCACTTGCTCATTCATACAAATGAGAAACCGCACGAATGCGAAATATGCAAGAAATCTTATCGACAAGAAATTAATTTGAATAATCATATCATAATGGCGCACACCAACAAAAGAGATTTTAAATGTCAGTTCTGCAGAAAGGCGTTCGGCTTAAAGACACATTTAAAATATCATTTGCGGATACACACAGGAGAAAAGCCTTATTCGTGTCCTCACTGTGAAACGAAGTTCGCTCAAGCTGGACAActTGAAAAGCATTTGGCTACACACGCTGAGCGGGAAAGGAAATGTTGCGAACTTTGTTTTACTACATTTACCAGTGAGCGTAATTTAAGGCTGCACATGGAACGACATGAGCAAGGACCAGGGATTGTTTGCCACATTTgcaataaaatattcaaaaatgacctaattttgaaaaatcattTGAGGTTGAACCATGGGAAAGTAAAACCTGAGTGTCAGATATGTGAGTTGCCTGTTGAAGGCGACATGCACACTCACATGAAAACTCATTTTCCAGACAGGTCAATTGAGTGTGAGGTATGCCATATTGCATTTGCTTCGAAGGCTCAGTACAATGTTCACAAGAGGAAACATACTGGAGAAAAGCCATTTACGTGCAGGGTAAGTAATCTTAAAGATGGTTTGTAA
Protein Sequence: MSQNGGAMKRSDFKDDASSSLRDSGISISEGLSESEPEINENASQNKKIRKNAARSKECHICIRTFKNGTDLRRHLLIHTNEKPHECEICKKSYRQEINLNNHIIMAHTNKRDFKCQFCRKAFGLKTHLKYHLRIHTGEKPYSCPHCETKFAQAGQLEKHLATHAERERKCCELCFTTFTSERNLRLHMERHEQGPGIVCHICNKIFKNDLILKNHLRLNHGKVKPECQICELPVEGDMHTHMKTHFPDRSIECEVCHIAFASKAQYNVHKRKHTGEKPFTCRVSNLKDGL

Sequence clustering based on sequence similarity using MMseqs2