Basic Information

Gene Symbol
ZFHX3
Assembly
GCA_004785975.1
Location
SMLS01071449.1:24616-39344[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.0012 0.18 13.1 0.2 1 23 117 140 117 140 0.96
2 15 3 4.5e+02 2.4 2.5 2 21 228 247 228 251 0.86
3 15 0.057 8.5 7.8 1.3 1 23 263 288 263 288 0.91
4 15 0.0032 0.48 11.8 1.6 1 23 306 328 306 328 0.97
5 15 0.00069 0.1 13.8 0.7 2 23 335 357 334 357 0.94
6 15 0.00018 0.027 15.7 3.1 1 23 464 488 464 488 0.92
7 15 0.0054 0.81 11.0 0.6 1 22 508 529 508 532 0.89
8 15 0.0011 0.16 13.2 0.2 1 23 580 604 580 604 0.93
9 15 0.0026 0.38 12.1 0.1 3 21 668 686 668 687 0.96
10 15 0.32 48 5.5 2.5 2 19 811 828 810 833 0.90
11 15 0.00012 0.017 16.3 2.5 1 23 1411 1433 1411 1433 0.99
12 15 0.00051 0.076 14.3 0.3 1 23 1525 1547 1525 1547 0.98
13 15 0.0063 0.95 10.8 0.4 2 23 1695 1717 1694 1717 0.96
14 15 0.00022 0.033 15.4 3.4 1 23 2146 2168 2146 2168 0.99
15 15 0.58 87 4.6 0.3 1 12 2260 2271 2260 2274 0.89

Sequence Information

Coding Sequence
ATGTGTAATTTTATTAGTACAGTAGATGTTTCATATATCGGAAGTGTTATAttcatttgtatgaaatatgtgACTAGGATACTAGTAGTCATAATTCGTATAACCAATGATGCGGTTAAACCTGaAAGAAGAGATAGCGTAAATTCAGACTCGAACATCATTGAACAACCCAAAGATCAACAAATCAAAACAGAGCCGAGCGAGGATATCGAAGAAATCAGGCCACCACGTGAAATATCGACGAACAGTCACATATGCCCGTATTGCGAATACTCGAACGATTCAGAAATGCGAATCCAAGCTCACATCCTAGCACAGCACGGTACAAACAGTTCCTCAGAAACACATTTTCAATGTCCATTGTGTCAGGATTCGTTCAAAGAACGGCCGAACCTTGAAAGGCACGTCATGCAAATCCATTCGGTAAACAACGAGGGCCTGCAAAGGCTTCTAATGCTGGTTGACCAAAGCCATTGGTTGAATCACGCCTCCAGAACGTCGACACCAAACAATTCAACGACGAACAATCAGATACAAACTGCGTCGCATCAACTAATATCACCCACATCGGTTTCTTCCAAAGACTCGAATAAATTGGACAAGAATGATTCTACGAATTTGGATGTTGAACCTGATATTATGTCGCCGAATAGTGATGATAATACAGATTTCGAATACGAAAGGTGTGGGACGTGCTTCAAGAACTTCAAGAATATCGACGAATTGTGCTTCCATCAAAATGAAACCGGACATTTGGAGATTAAACAAACCCCAAGCGGCCCGGGATACGTCTGTTGGAAAAAAGGCTGCAACCAATTTTTTCCAACAGCACATACGTTACAGATGCACTTCAAAGACGTCCATGCCAAAAATTCGATAACCACTATGTCGGTATCGGAGAAACACGTGTACAAATATAGATGCAATCAGTGTTCGTTAGCCTTTAAGACGTTAGAAAAACTTCAATTACATTCGCAATATCACCTCATCAGAGATGCTACGAAATGCGTGCTATGTGGGCGCAGCTTTAGATCGCTGGTAGCTTTACACAAACATGTCGAAAGTGTTCATTCAGAATTGACAGATGAAGAACTGGCTGCGTACAAACAAAGTTTAATGAACAATCCGTTGCTATTAGCCGGATTACAAGGGCAAGTCCTAGATAGTTCAACCAATGATCTCTTAAAAAAAGAATCTCTACGCGCAGACGATGTAGAATATAACGATTGTGATGATGGTAAAGATCTGAATACAAGTCACGAAGATAGCAATCAGAATGATGGAGAAAATTCAGATGATAGCATAATTTATAAAGATCAGCAGTTCttagaagattatttaaattctcAAGCGATTGCCGAGGACAGCTACAATGACCCAAATAGAAAGTATAAATGTCACAGGTGTAAAGTAGCATTTACTAGGCAGAGCTATCTGACCGCCCAtaataaaactttgttacaCAGAAAAGGTGAGAAACTAAGCTATCCCATGGAGAAGTACCTGGACCCGAATCGGccttacaaatgtgacgtatgcAAGGAGAGTTTTACgcaaaagaatattttgttaGTTCATTACAATTCAGTCAGTCACTTGCATAAGTTAAAGAGGGCGATGCAGGAACAACAGcagaataacaataataaccCACCTGTCTCGCCGATAATAAGTCAGCCGCAAAATATGACTTTAACGCCTAAGAGTACGTCATCGGAGGAAGACGATAAAAAACGATATCGTTGTAATATATGCAAAGTAGCGTATACTCAGGGTAGCACTCTTGATATTCATATGAGGAGCGTCTTGCATCAGACGCGTGCGAGTAAGTTACAAGATTTGGCGCTCACGGGGCAGATAGATCTCTCGAAACCGCTTATCGAACAGCCCGAAGCCATGCAGTCTCCTAAACAATCGAGTCCTACACCCTGTAGTGGGGAGAAGGGTTCTCCCACCCCGCCGTCACCTGGATTGGGTGCAGGTAGTCAAGGGATGATGGGCTGCCCTAAGTGCGGCGCGTTATTCAGTTCGCAAGACCAGTTGAGTGCACACCAACAATTATATTGTATGTTCGCCGCACCGATGGCTATATTTCAACAGGCGCAAGAGCCTGGACAGGCGAAAAGTCCACCACCCGGCGATCAAGATCTAGTtagcaaattaaatttaccGAAGAAGACCGGGTCGCATATGTATAAACACCTGTTGGAGAGTTTCGGTTTCGATCTGGTAATGCAATACAATGAAAGTCATCAGAGGCGGCAGAGACAAcaacagcagcagcaacagGCGCAACAGCAGCCTCAACAGCAACATCGCGAAGTTGAAGAGAAGATACATTCACCGCCACCCACCCACGATGTCGATCTAGACGCTACGTCGAGGACTGAGGAGGAGATTGAAAGCAGCTTGCCAGAAGTAAGTAGATCCACGTGCCAACATTGCAATAAAGAGTTCTCTAGTGTGTGGGTGTTAAAATCTCACTGTGAAGAAGTACATAAAGATTTAGTGCCACTAGAATTCTTAGAAAAATATGCTCAACAGTTCAAGAACGAATACGAAAAGAAATCTGTGGTGGTGACGGCCGCAACATCGTCTTCAACTTTAAACACCGATCCGAGAGTTACCACCCCGGGCGCTACAACGACCACGACATCGCCAGCGGACACCACGCCGGAAAAGGAAGACGAATCCAAAGAGGCGTTACATGCGAAATTAAACTTACAAAGTACGCCTGAAGTAACGGCCGCATCTACGGCTCCTTCGACACCGACCTCTTCATCGACACCGGCGAGCAGTACGGACTCGTTGCCCGCGAATATACAAGCGATGATTGCGCAAAGTATGGCACAGAATCCGATGGCACTAGCGCAACAAATGTCCGAGATGCAAGCCGCTCTAAACGTCATGCAATTGCAGCAACAGTTAAACTTTAATCCTATGATGCAGATGATGGGCATGGGTCTGCCGCTCGGTCTGAACGCACTGGCCGCGATGAACCTACAGCCGCCTCTCGTTCCTCTCATGATGCCACCGCCACCGTACGATCCGATGTCGCAGTTCGCATCGCAAGATCCACAGACCATGCTAGCGAAGCAACAAGCGATGATTCAGCAACAAGCGGCCGTTAACGCAGCTGCCAATCAGAAACGAGCTAGAACTCGCATTACCGACGACCAGTTGAAGATCTTGCGATCCCATTTCGACATCAACAACTCGCCATCTGAAGAGCAAATACTCGAGATGGCCTCACAGAGTGGCCTACCACCGAAGGTCATAAAGCACTGGTTCAGAAATACGCTATTTAAAGAACGCCAGCGCAACAAAGACAGTccatacaattttaataatccACCATCGACTACACTAAACTTGGAAGAATACGAAAAGACTGGCGAGGCGAAAGTGCTGCCTCTAAACAGCTCAGGTAGTAGTACAGAAGAAAatgccattaaaaataaatccccaCCACCGCCTTTGCAGAACGAAATTAAGAGTGAAATGAAAGAagaactggtggaagatatgcCCTCTACCAAATATCATAATATCGAAGAGCATAAGCATCCATCAGACGATCTTGATGAGAAACCTAATATTTTTAACTTAGCGTCGAACCTACAACCACCTCCGAGTCCAGCTTCTTCGATAAGCGGTTCCGAATCGCATAATATGAGCCATTTATCCACTCCAAATACACCAAACAGTCTCACTCTGACATCCATTATTGCTTCACAACTTGGAGACACAATGACCACGACGAGCACACCAACTAACCTAAATATGACATCCTCAGCGCAACATCCTTTACAAAGTCCAATGTTACCGCCGCCCAAACTAAACCAGCAAGTTTTTCCCAGTCCTAACAACTTACAAAACATGTTACCTCTAACTCCAAATAGATGTCTAAGTCCCAATCGAGATTTTCAAGGTTCAGGATCAAATTCTAGTGGTGGAAGTTCTGGTAAAAGAGCTAATAGAACACGTTTTACAGACTATCAAATTAAAGTATtgcaagaattttttgaaaataacgctTACCCAAAGGATGACGACTTGgaatatttatcaaaactacttaGTCTAAGTCCAAGAGTGATAGTTGTATGGTTTCAAAATGCAAGACAAAAAGCTAGGAAAGTATATGAGAATCAACCAGCTGCTGAACCAGCCCCTGGAATTCCAGAAGAAGCTGGTACCAATAGATTTCAAAGAACACCAGGGTTAAACTATCAATGTAAGAAATGCCTACTTGTGTTCCAAAGATACTATGAATTAATACGACACCAGAAAACGCACTGCTTCAAAGAAGAAGACGCAAAAAGGTCTGCGCAGGCTCAAGCAGCAGCTGCTCAAATTGCTGCCGTCCTCAGTTCCGAAGATTCTAATAGTAGTACAACCATAGAACAAAACCAACAGCAACCGCCTATACCGCAAAGTCCTCAAATCCAAGGTACCTCTTCGCAAAGCCCCATTCAACCTAATCCACCAACAACACCCACACCGACAAGTGGAAATTTTCCGAACTCTCCTATGTCTTCCTCTGGCACAACCGAAACGAAAGAAGGCACATTTCAATGCGATAAGTGTAACCTAGTATTTCCCAGATTTGATCTTTGGAGAGAACATCAGCTAGTTCATATCATGAATCCAAATCTGTTTCCGTCATATCCTCCCGATTCTCCTTTTGGTATCCTGCAGCAACATGCCCAACTACAACAGTTAAATGCTAACCTGGTAACAGAACAATCTAACAATAAGACAGCCTCCCCAATTCCTCATCCACTTATGAACATGTTGAACAATGTGAAtgctcaaaaaagaaaattggaaGAGTACGATGGAGAAAGTGACGTTTCCGATCAACCTAAAGATAAACGATTACGAACAACCATTCTACCCGAACAGCTGGATTACCTTTACCAAAAGTACCAAATTGAAAGTAATCCTTCCAGGAAGATGCTAGAAAATATAGCCAGAGAAGTGGGATTAAAGAAACGAGTGGTGCAAGTGTGGTTTCAAAACACCAGAGCTCGCGAACGCAAAGGGCAATTTAGAGCACATGCCCAGGTGATTAACAAAAGATGTCCTTTCTGTCCAGCCCTCTTTAAAGTAAAATCTGCTTTAGAATCACATTTAACGACCAAGCATGCGGATCAGTGCGCCAGAGGTGAAATCAACATTGATGCCTTACCGGACGAAGAAGCAAGCCTCGAATCGTCACCTAGCTTAAGTTCGGGCGGTGATAATAAATTCCAACAAACTCCTGCTGGCATGATTCCTCCAATGTTTCACAGTATGAATCCAGAAATGGAGAATTCAATCAAGAAATACTATGAAGAGAGTATGAAAAGGTATATCAGCGAACTGCAAGCACATGCTGCCTCCTCTAATGGTgataaaagtgaaataaaaactGGTAAAGAAGAAGGCGAAATTCCATTAGATTTGTCTAAACCTGTTGACCTGTCGCGGCCTATGAAAGTTAATATGGACCATGAACGAAATCTGTGTGATCCAGGCCCTTTAACGGATTTAAGTGAACGATCTCTATGTGATGAAAGAAGTGATTCTATGTCGGAAACTACCGAATTCTACGACGATGAAAGTAATCCCACATCACCCGCCAGTAGTACACAAAGCAATCAACGGCCCCCAACATCCGGTAGTGGTAATACTGGGGGAGGTGGAAGTAACAGTGGTACAAAAAGATTTCGAACTCAGATGTCTTCGGTACAAGTGAAAGTTATGAAGTCTTTATTCGGTGATTACAAAACACCAACCATGGCAGAGTGCGAAATGTTGGGTAAAGAAATCGGATTACCCAAACGCGTCGTGCAAGTGTGGTTTCAAAACGCTAGAGCGAAAGAAAAGAAGGGTAAACTAGCCTTACAAAAAGTTCTCGGTAATTCTGAATCGGAAAATCCGCCGTTACCCGACGATTGCAAGTACTGTTGTTTCAAGTATTCACACAAATACTCGATCCAAGACCACATATTCACGAAAAGCCACATAGCCAATGTTAGAATTCATCTAGAAAACGCCAGTAAAGATAATATGTGTGATGGTGAATTTACGGTGCCTCCAATACCCGGTGCTTCTGGTGCGGTGTCCGCTGACTCCACTACGAATCCTCAACAGCAAAACTTGAACAACAACACCCAGTTGCAGTTGCTCCAAATGGCGGGTATTCAAGTTGGTGCCAACAAGGTTGAACAAGATGATAACCAAGAAGCCTTCTTCCAGCAGCTCTACGGCCTCAGCAGTAACAGTTCATATGGTGCTCAGAATCCGTTCCTCCAGCATGCTGTCTTCGGCGCTAGTGGtgaACAAAAAGCTAGGAAAGTATATCAAAATCAACCAGCTGCTGAACCCGCCCCTGGAATATCAGAAGAAGCTGATACTAATAGATTTCAAAAAACAGCAGGGTTAAACTATCAATGTAAGAAATGCCTATTTGTGTTCCAAAGATACTATGAATTAATACGACACCAGAAAACGCACTGCTTCAAAGATGAAGACAGAAAAAGGTCTGCGCAGGCTCATGCAACAGCTGCTCAAATTGCTGCCGTCCTCAGTTCCGAAGATTCTAATAATAGTATAATCATAGAACAAAATCAACAGCACCCGCCTATATCGCAAAGTCCTCAAATCCAAGGGACCTCTTCACAAAGCCCTATTCAACCTAACCCGCCAACAACACCCAAACCGACAAGTGGAAATTTTGCGTACTCTTCTATATCCTCCTCTGACACAACCGAAACAAAAGAAGGCATATTTCAATGCGATAAGTGTAACCTGGTATTTCCCAGATTTGATCTTTAG
Protein Sequence
MCNFISTVDVSYIGSVIFICMKYVTRILVVIIRITNDAVKPERRDSVNSDSNIIEQPKDQQIKTEPSEDIEEIRPPREISTNSHICPYCEYSNDSEMRIQAHILAQHGTNSSSETHFQCPLCQDSFKERPNLERHVMQIHSVNNEGLQRLLMLVDQSHWLNHASRTSTPNNSTTNNQIQTASHQLISPTSVSSKDSNKLDKNDSTNLDVEPDIMSPNSDDNTDFEYERCGTCFKNFKNIDELCFHQNETGHLEIKQTPSGPGYVCWKKGCNQFFPTAHTLQMHFKDVHAKNSITTMSVSEKHVYKYRCNQCSLAFKTLEKLQLHSQYHLIRDATKCVLCGRSFRSLVALHKHVESVHSELTDEELAAYKQSLMNNPLLLAGLQGQVLDSSTNDLLKKESLRADDVEYNDCDDGKDLNTSHEDSNQNDGENSDDSIIYKDQQFLEDYLNSQAIAEDSYNDPNRKYKCHRCKVAFTRQSYLTAHNKTLLHRKGEKLSYPMEKYLDPNRPYKCDVCKESFTQKNILLVHYNSVSHLHKLKRAMQEQQQNNNNNPPVSPIISQPQNMTLTPKSTSSEEDDKKRYRCNICKVAYTQGSTLDIHMRSVLHQTRASKLQDLALTGQIDLSKPLIEQPEAMQSPKQSSPTPCSGEKGSPTPPSPGLGAGSQGMMGCPKCGALFSSQDQLSAHQQLYCMFAAPMAIFQQAQEPGQAKSPPPGDQDLVSKLNLPKKTGSHMYKHLLESFGFDLVMQYNESHQRRQRQQQQQQQAQQQPQQQHREVEEKIHSPPPTHDVDLDATSRTEEEIESSLPEVSRSTCQHCNKEFSSVWVLKSHCEEVHKDLVPLEFLEKYAQQFKNEYEKKSVVVTAATSSSTLNTDPRVTTPGATTTTTSPADTTPEKEDESKEALHAKLNLQSTPEVTAASTAPSTPTSSSTPASSTDSLPANIQAMIAQSMAQNPMALAQQMSEMQAALNVMQLQQQLNFNPMMQMMGMGLPLGLNALAAMNLQPPLVPLMMPPPPYDPMSQFASQDPQTMLAKQQAMIQQQAAVNAAANQKRARTRITDDQLKILRSHFDINNSPSEEQILEMASQSGLPPKVIKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYEKTGEAKVLPLNSSGSSTEENAIKNKSPPPPLQNEIKSEMKEELVEDMPSTKYHNIEEHKHPSDDLDEKPNIFNLASNLQPPPSPASSISGSESHNMSHLSTPNTPNSLTLTSIIASQLGDTMTTTSTPTNLNMTSSAQHPLQSPMLPPPKLNQQVFPSPNNLQNMLPLTPNRCLSPNRDFQGSGSNSSGGSSGKRANRTRFTDYQIKVLQEFFENNAYPKDDDLEYLSKLLSLSPRVIVVWFQNARQKARKVYENQPAAEPAPGIPEEAGTNRFQRTPGLNYQCKKCLLVFQRYYELIRHQKTHCFKEEDAKRSAQAQAAAAQIAAVLSSEDSNSSTTIEQNQQQPPIPQSPQIQGTSSQSPIQPNPPTTPTPTSGNFPNSPMSSSGTTETKEGTFQCDKCNLVFPRFDLWREHQLVHIMNPNLFPSYPPDSPFGILQQHAQLQQLNANLVTEQSNNKTASPIPHPLMNMLNNVNAQKRKLEEYDGESDVSDQPKDKRLRTTILPEQLDYLYQKYQIESNPSRKMLENIAREVGLKKRVVQVWFQNTRARERKGQFRAHAQVINKRCPFCPALFKVKSALESHLTTKHADQCARGEINIDALPDEEASLESSPSLSSGGDNKFQQTPAGMIPPMFHSMNPEMENSIKKYYEESMKRYISELQAHAASSNGDKSEIKTGKEEGEIPLDLSKPVDLSRPMKVNMDHERNLCDPGPLTDLSERSLCDERSDSMSETTEFYDDESNPTSPASSTQSNQRPPTSGSGNTGGGGSNSGTKRFRTQMSSVQVKVMKSLFGDYKTPTMAECEMLGKEIGLPKRVVQVWFQNARAKEKKGKLALQKVLGNSESENPPLPDDCKYCCFKYSHKYSIQDHIFTKSHIANVRIHLENASKDNMCDGEFTVPPIPGASGAVSADSTTNPQQQNLNNNTQLQLLQMAGIQVGANKVEQDDNQEAFFQQLYGLSSNSSYGAQNPFLQHAVFGASGEQKARKVYQNQPAAEPAPGISEEADTNRFQKTAGLNYQCKKCLFVFQRYYELIRHQKTHCFKDEDRKRSAQAHATAAQIAAVLSSEDSNNSIIIEQNQQHPPISQSPQIQGTSSQSPIQPNPPTTPKPTSGNFAYSSISSSDTTETKEGIFQCDKCNLVFPRFDL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2