Basic Information

Gene Symbol
Mbd2
Assembly
GCA_037055365.1
Location
JAWJWE010000001.1:1723720-1725523[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.9e-09 4.5e-06 25.6 0.3 9 74 11 96 4 99 0.91

Sequence Information

Coding Sequence
atgtCGAGTGATAAGAGACGATACGAATCGTCCAGCATCTCAAAGTCGTGGGGAAGGGACGACGTTATGAGAAAACAGAGTCTCTCCTCAGGAAAAgttgatatttattattacagCAGGGGAATGAGAAGTGATGCATCTCTGGTTCCACCCATAAGACAAACTGcatcaatttttaaacaacCAGTAACAGTTCACCGAACTCAGGCAGAAGGAAAAGTCAAGTCAGACTTCAAGCATGGAACACAGGAGAAACCAAAGCAGCTCTTCTGGGAAAAACGTTTGGAAGgtCTTAGAGCTTGTGATATTGATGGGCACGAATTTAACATAATGGAGCTTCCCAAGAGTCTGAAGACCATAGGACCTCACATCGCAGATGAAACTATCCTGCAGTCTGTGGCTACAGCGTTGCACGTGTCGAGTCAGCCTGTGACTGGGCAAAACACCCTGAAAACCAGCATGGACAAAAATCCAGGTGTCTTCATAAATCCTGAACAGCCGTTGGTTCAGGCTGTCAATGTATCCGACGAAGACATCAAGAAGCAGGAGGAGAAAGTACTGATTGCTCGCAGAAAACTTCAGGAGGCCTTGTGCGTTCACTAA
Protein Sequence
MSSDKRRYESSSISKSWGRDDVMRKQSLSSGKVDIYYYSRGMRSDASLVPPIRQTASIFKQPVTVHRTQAEGKVKSDFKHGTQEKPKQLFWEKRLEGLRACDIDGHEFNIMELPKSLKTIGPHIADETILQSVATALHVSSQPVTGQNTLKTSMDKNPGVFINPEQPLVQAVNVSDEDIKKQEEKVLIARRKLQEALCVH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00362539; iTF_01164907;
80% Identity
-