Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.2e-11 7e-08 34.3 12.8 2 68 54 123 53 125 0.87

2 3 9.7e-05 0.57 12.2 2.9 1 23 162 184 162 189 0.89

3 3 0.00013 0.77 11.7 1.7 55 70 190 205 184 205 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.2e-11	7e-08	34.3	12.8	2	68	54	123	53	125	0.87
2	3	9.7e-05	0.57	12.2	2.9	1	23	162	184	162	189	0.89
3	3	0.00013	0.77	11.7	1.7	55	70	190	205	184	205	0.86

Coding Sequence: atggCAACAATGAATGAACAAAAGCCAGCCAATGTTGAGGTGGTCATAGACAAAAAGGCTCAAAAAGCAGGCGAAAAAATGTTAAGAGCCCAAAAAGAACAAGAAATTTATCACAACTTTGCAACGCCTTTAGTAGGCACCTTCTTGAATTTAACCCAAGAACCGGCCTTAATTAAATGTCCCAGTTGTGGCATAGAAGAACTAAGCGAAGTTGTGGATGAGTTAAAATGGTGGGCCACTGAAATTAATCGTTTTGTTGGATGTTTATTTGTTTCAttgtgttgttgctgttgtttggACTATTCCCTGCCCTGTAAATCCAGTGATCGTAATcattattgtaaaaattgtggCTGCTTTTTTGGGCGGGCCATGAGAATTCCGCctttgaaaaaaGTTATTTTAAACATTGTGAACTACTCAATTTCTATTTCGACCATGCAAAACGAATCTCTGCCACCACCTGTGTACTTTGCTGTTGGTCCCCAACCCCATGAGGTCTCCTGTccattttgtaaacaatacAGCAAAACAACAATGAAACGTTCAATTCTTCGTTGCTGCCTACGCCGCCATTATTGCTCCCAGTGTGGGGAATATTTGGGTTCTTATAGACGTCCTCAGCTGTAG
Protein Sequence: MATMNEQKPANVEVVIDKKAQKAGEKMLRAQKEQEIYHNFATPLVGTFLNLTQEPALIKCPSCGIEELSEVVDELKWWATEINRFVGCLFVSLCCCCCLDYSLPCKSSDRNHYCKNCGCFFGRAMRIPPLKKVILNIVNYSISISTMQNESLPPPVYFAVGPQPHEVSCPFCKQYSKTTMKRSILRCCLRRHYCSQCGEYLGSYRRPQL

Sequence clustering based on sequence similarity using MMseqs2