Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 9.9e-05 1.4 10.3 0.1 16 50 41 75 32 79 0.85

2 6 0.00021 3.1 9.2 0.2 23 45 76 98 72 101 0.89

3 6 0.0018 27 6.2 0.2 20 44 101 125 97 134 0.85

4 6 0.023 3.4e+02 2.7 0.1 21 44 130 153 127 161 0.86

5 6 0.0007 10 7.6 0.0 23 45 160 182 154 188 0.91

6 6 1.6 2.4e+04 -3.2 0.0 22 33 213 226 211 230 0.65

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	9.9e-05	1.4	10.3	0.1	16	50	41	75	32	79	0.85
2	6	0.00021	3.1	9.2	0.2	23	45	76	98	72	101	0.89
3	6	0.0018	27	6.2	0.2	20	44	101	125	97	134	0.85
4	6	0.023	3.4e+02	2.7	0.1	21	44	130	153	127	161	0.86
5	6	0.0007	10	7.6	0.0	23	45	160	182	154	188	0.91
6	6	1.6	2.4e+04	-3.2	0.0	22	33	213	226	211	230	0.65

Coding Sequence: ATGACCTCAAGAGGAGAGTTTGAGGAAACAATGCCTATTAATGGTGTAGTCGCTATGTACACATGCAAGAGATGCAACAAGATATTCCCCTgtaagcgtgaccagcttctgcataaaaaagaagtgcattcccaaacgaaatcatcctatgagtgcaaaatatgttcaaagttcttctgcaatagcggtaatttggagcgtcacatgaaagttcacaatgatgtgagaccttttgtttgtcgcatctgtggcaaggccttcgcccagtctgttaatctaaatcgtcactattcagtacataatggtgaacgtccgtacccatgtacgttttgcactaaaacatttacccaacaatcaaacatgcaacgccatcagctaacacacacaggtgaaaaaccttttcgctgtaaacgttgtggccgctatttttcccaacgtgttaaccttaaaaagcatattatgggtcatttaaatacaaaaccatacacgtgcaaaatctgtcaaaaatcgtttatacaattgggcaattttaaaaaacacctacaatctcatatcaaggatggcatagaaattgatatgAAGTCGCTTGTGGCCGAAGCGCAGGCGATGGCTAAACAGAGTTTGGAAATGGCTGATGAGCAACCAGTTGGCTTCGAATGCGCCGTCTGCCGTTCAATTTTTAACAATTTCACCGACTTTGAAATGCATGAAAGCGAGTGCAACGATAATGCACAGGCTGCCATGGAGCAAAAATACAATCCAGATCAACAACTACACGAAGTTGTTGTCGAAGAGGTCGAAGATCATGTTGAAGAACATGTTATACCACACGAAGGTGGAAGCAGTGTTAGCCATTTTGGCAGTTTTGCCCCCTTAAAATTTAGTGTCTCACAGTTAGATACACATGAAATAATTATTGAAACCAGTCGATAA
Protein Sequence: MTSRGEFEETMPINGVVAMYTCKRCNKIFPCKRDQLLHKKEVHSQTKSSYECKICSKFFCNSGNLERHMKVHNDVRPFVCRICGKAFAQSVNLNRHYSVHNGERPYPCTFCTKTFTQQSNMQRHQLTHTGEKPFRCKRCGRYFSQRVNLKKHIMGHLNTKPYTCKICQKSFIQLGNFKKHLQSHIKDGIEIDMKSLVAEAQAMAKQSLEMADEQPVGFECAVCRSIFNNFTDFEMHESECNDNAQAAMEQKYNPDQQLHEVVVEEVEDHVEEHVIPHEGGSSVSHFGSFAPLKFSVSQLDTHEIIIETSR

Sequence clustering based on sequence similarity using MMseqs2