Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_943735935.1
Location
CALSEV010001501.1:436608-443194[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.5 4.4e+03 -1.4 0.0 43 71 91 178 60 182 0.64
2 3 2.2e-21 2e-17 63.8 0.1 4 76 421 491 418 492 0.93
3 3 1.9 1.7e+04 -3.3 0.0 45 63 929 945 927 950 0.77

Sequence Information

Coding Sequence
ATGGGTCGCCGGTGTTGTATAGCCGGGTGCAGTTCAACATCACGCTTACCGGAACATCATGGTGTTACTTACCATTCCTTTCCCTCCGATCAAAATGCACGCTCTGTTTGGATACGCAATACCAAAATAAGTGCTGATCGCCACCTTACGAAAAGTGTTTTGGTTTGTTCCAGACACTTTCGGCGCGCAGACTTCCAGCCACAGCGAAGTGGTAAATATATGCTAAAACAAAAAGTGTTTCCCACAGTATTTCCCTGGGGTAAAATAGATGCGGCCCAGATTGAGGAAGATTTGGAATTTTTAAATTCAACAGGCTCGGCAGCGCCAAGTAATTTGTTGACTACTTCCTCTACGGTAGATGAAGATACAAAAGCTACCGTGGCTGCCACGGTGGCACAGATAATGGCACAAACTGCTGAATTGAATGCAGCAGCTGGCATAAAAGTGGAAAAAGTTGATGGTGGTATGGATGAAACTTTAAATGATGCGGCTGCTGTTAATCCATCTACGCCTCCAAATTTTAAGTTTGAACCAGTGACTTCCTTTAATCCGGGAGCTCGTTTAGAGGCTCAGGACTTTGATGGCATTTGGCATACAGCACGTATTGTTGAAGTTGATAATGATGACCGTGAGGTACTCATTAAGTTCGAAAAGACTGGTAAAAATAAATCAAATATGGCTGGTACCGAAGAATGGATACCTATGAATTCTTCTCGCCTTAGACAACGTATTTCCACAAAACCCATATTAAATTTCGAATTGGAGGAGAAATGTTTAGCACGTTGGTCGGGTCCACGAAAATTTCCTGGCACAGTTAAGAAGATTTTACCCAATGATGTATATGAGATTTTATTCGATGATGGTTACGTGAAGAATGTTCGTGCTATTCATATGAATAAAATGCAGCCTATAGCTATGTTGGAACCAGAAGTTGTAGAGTGTGTGCCAGCTGAAGTTTCTGCTATGGTACCGGTTACTCCCGCTGACACCGTTGAAAATTCGTTGCCCTTGCCGGTAACCCCTACTACCATTTCTGTTAAAAGGCCTTCTTCTGGACAGAATTCTGGCTCTAACCCTAAAAAACGTGCTCCGAATGGACCAAGAAAGGATTGGCCTCTGCTGGATTTATCAAAATTGAATTTATCCTCCCTTAATCTTCCAGAAATTCCCAAAGATGGGGAATGGACTTGTCATTGGGTTAATGATCAGCCCATTGGTCGCGAAGGATATTTGGTTGTTGGGGAACATCGTAAACCCACAGTAATAGTAGAAGATTGGCGTTTACCTTCCGGATGGGTAAAGCATATGTATCAACGTTCCAATGTTTTGGGAAAATGGGACGTTATATTAGTCACACCAAATGGCAAACGTTTTAGATCGAAAGCTGATCTAAAAACTTACTTGGAGGAACTGGGTCAAGTATATAATCCTGACATTTATGACTTTAGCATCCACCGCCGAAGAGCCAAAGATATCAATTGTTATGTTTACACATCCGACTATGTGCCCCAACAGCCAGTAAAATCAAAGTCTTCACTAAATACTTCTCTTGATACTAGCTTAGAAACTAAACCTTCAGATTTAGCGGGAACAATAGCGGCTGTCTCGTCTCCTTATATTGATACTCCTATCGCTGAAGCTCTGCCACCCATAGAGTTGTTAACAACTTCCTCGAGTAGCTTAGCTGCTGAAGATAAAAGTGTGACCCAGGTAGAGGCAGAAGTACCAAAACAGTTGTTAGAATCGGCCGAAGTTAGTTCGACACCAACGCCTACATCTACGCCTACAGTAGGTTTTAAAGAAGAGGCTGCCGTTTCATCAGATTGTGCAACGCCTACACCTATTTTAGCAGCAGGAGCAACAACATCGGATATTCCAACTGCTGAAATATCGCAAAAAGTTGAGGACGGTTACGCTCTTATTGGCGGCCTAAAAGTGCAAATCATAGATAATCTATTTCGTTGTCCCCAGGAGGGCTGCTTAAAGAATTTCCGCAAAGAAAATCATTTGCAAATTCACGTTAAGCATTATCATCGCAATTTAATAAAATTACTTGGTTCTTGCCCTAAAATGTTGGAATTGGCCGAAAAACGCACCCATCCTGTTGACAATGATGCCGCAGAACCAGTGCCTAAAAATCAAATACCCAATCAACAGTTTTTTGCTAAATTGCATCAGCAAGATTTAGAACAAACTAGAGCTCATCGCAGAAGTACTGGAGCTCTAAAGAGTTTAATGGAATTACCGCCTACAGAAATTAAAACAGAACATTTGGACGAATCTTCCATTAAAGTAGAGGAACAAAATATGGATACCTCACAAAATGATACTTCTGTAAATAATAACACTACAGTTTCTAGCGCTCTTTTGGAGAGTTCTTTTGCTTCAACAAGTGCAGCAGATGAGTCAGTGGTTGCTGAAACATCAGGAGCTGAGCCACCGGCCAATAAAAGATCTAGATTTTCAACCAGTAAAAGATCATCTGGCTCACGCAAAAGTAATCGACAAAGAACTACTAGGAAATATCTTACGGCAGCTCAGGCTACTGCAGGTGTGGTAGGATCCGTCATCCCTTTACCAATAGCACCTGATACTAGTTTCAGTGGCGTGGCAGAATTTGAGGAGACTCGCCATTCTTTTAATGCTACACCGGAAATCAATAAAGATGCCAAGAAACGTAAAATCGTGCTGCCCTCTAATACCCCTCTTAGTAGCGTTGATTCTCCCATAACAGCCGACTCCGGCTCAAACTCGTTTCAACTTCAAAATCCCACGGACATCGATATAATTAATCAACCTCCCCAATACATCAAGGAAAATGGTGAATTAATAAAAATTGTACACATGCGTCAAGAAGAAATCATTAATTGTTTGTGTGGCTACTGTGAGGAAGATGGCCTTATGTTACAATGTGAACTTTGTTTGTGTTGGCAGCATGGCCTCTGCAATGGCATTGATAAGGTCCTGCAGGTCCCTGATAAATACGTCTGTTATATATGTCGTAATCCCCAAAGAGCTCGCGAGTCTGTACGATTTAAACATGACCAAGATTGGCTGTATGAAGGCAAATTACCCGTGGCTAACTACCATGCTTCCAATTCTTCTCAGCTAAACAAAAGAGCCGAGTACCTTAAACGTTCCCATATTTTAACTGGCAATCTTTTGGAGTTGAAAAACTATATGCATTCGCTAAGAGTTAAAATTAATATAGCCAACAATAAATGTCATCCAAAACTTTATTTATGGGCAAAGAAATGGGATGAAGATGTGCCAGCAGTAAAAAATGAAATTAAATATGAAACCGAGGAAGACAAAACAAACAATGCTAGTATGCCTGTAACACCCACAAAGAAAATCAAATCCGAACCTACAACCCCGGCCCGTCTAGTGCCAAATATACCTCAACCTGAGGCGCCCATAGATCCAATTGAATGCCAGCAGCGTTTAATGGAACACATTAAGATACAGCAGGAATTAGTTTTGGGACGTTTAGGTTATATAGAAGCGGCCATAGATGTTTTGGAAAGTGAAGATGATTTGCCAGATTTGCGTGAGGACGATTTAGGTGCCACCAAGGATGCTTTAGCCGCCTTTATTAAAGAATTGGACACTGTTAAACTAATTGCCAAGCTAAATAGTTTGGAACATACTAAACTGGCGTACAAAAATCCCATAACTCCAGTTAAATAG
Protein Sequence
MGRRCCIAGCSSTSRLPEHHGVTYHSFPSDQNARSVWIRNTKISADRHLTKSVLVCSRHFRRADFQPQRSGKYMLKQKVFPTVFPWGKIDAAQIEEDLEFLNSTGSAAPSNLLTTSSTVDEDTKATVAATVAQIMAQTAELNAAAGIKVEKVDGGMDETLNDAAAVNPSTPPNFKFEPVTSFNPGARLEAQDFDGIWHTARIVEVDNDDREVLIKFEKTGKNKSNMAGTEEWIPMNSSRLRQRISTKPILNFELEEKCLARWSGPRKFPGTVKKILPNDVYEILFDDGYVKNVRAIHMNKMQPIAMLEPEVVECVPAEVSAMVPVTPADTVENSLPLPVTPTTISVKRPSSGQNSGSNPKKRAPNGPRKDWPLLDLSKLNLSSLNLPEIPKDGEWTCHWVNDQPIGREGYLVVGEHRKPTVIVEDWRLPSGWVKHMYQRSNVLGKWDVILVTPNGKRFRSKADLKTYLEELGQVYNPDIYDFSIHRRRAKDINCYVYTSDYVPQQPVKSKSSLNTSLDTSLETKPSDLAGTIAAVSSPYIDTPIAEALPPIELLTTSSSSLAAEDKSVTQVEAEVPKQLLESAEVSSTPTPTSTPTVGFKEEAAVSSDCATPTPILAAGATTSDIPTAEISQKVEDGYALIGGLKVQIIDNLFRCPQEGCLKNFRKENHLQIHVKHYHRNLIKLLGSCPKMLELAEKRTHPVDNDAAEPVPKNQIPNQQFFAKLHQQDLEQTRAHRRSTGALKSLMELPPTEIKTEHLDESSIKVEEQNMDTSQNDTSVNNNTTVSSALLESSFASTSAADESVVAETSGAEPPANKRSRFSTSKRSSGSRKSNRQRTTRKYLTAAQATAGVVGSVIPLPIAPDTSFSGVAEFEETRHSFNATPEINKDAKKRKIVLPSNTPLSSVDSPITADSGSNSFQLQNPTDIDIINQPPQYIKENGELIKIVHMRQEEIINCLCGYCEEDGLMLQCELCLCWQHGLCNGIDKVLQVPDKYVCYICRNPQRARESVRFKHDQDWLYEGKLPVANYHASNSSQLNKRAEYLKRSHILTGNLLELKNYMHSLRVKINIANNKCHPKLYLWAKKWDEDVPAVKNEIKYETEEDKTNNASMPVTPTKKIKSEPTTPARLVPNIPQPEAPIDPIECQQRLMEHIKIQQELVLGRLGYIEAAIDVLESEDDLPDLREDDLGATKDALAAFIKELDTVKLIAKLNSLEHTKLAYKNPITPVK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01174299;
90% Identity
iTF_01235775;
80% Identity
iTF_01235775;