Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_002278615.1
Location
CM008235.1:9486951-9491403[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.1e-16 3.3e-12 46.1 0.0 8 70 433 493 427 499 0.94
2 2 0.4 2.1e+03 -1.4 0.0 42 60 1082 1100 1081 1111 0.84

Sequence Information

Coding Sequence
ATGGGGCGTAAATGTAACGTGTTAGATTGTCCATCGGATTCAAAGCGCCCCGAAGATAATGGTGTTACATTTCACAAAATGCCCTTTCATCCAGATTTACGTCCGAAATGGATTGAATTATGTCGTATTCCAGAAGACCGACAgctaaataaagtaatatatgtatgttccCGACATTTCCGTCGGAcagatttttgtaatttcaaaGGCACAAAGTATATGTTACGACAAGGTGCTTTGCCCTCCGTTTTCCCTTGGACTAGaagctttattaaaatctCCTCAAAATGCTCTACATCGGGGGATGAAAGTAAAAGCTCAGAAACATCAGATATTAAAACGGAACCTATGGATACAGACTCTAAGTCAAATGATGATCTAGAAATGCCAAAAATTAAAGAGGAACCAATGGACGAAGATGATTTcaaacctaaaataaaagataacgaTAAACCACCTAAGATTAAAAAAGAAGTCGATgataaaccaattaaaattaagaaagaaGGAGATGATAAACCTCCTAAATTAAAAcgagaaaatataattgttaaaaaagagAATGATACACCAGCCGCCTTACCTCCGAAACTAAAAGATGAAACACCAATTTCTATTAACTTTTGCGCTGGAACACGAATAGAAGCAAATGATTTTAACGATAAGTGGTATCCGGCTACAATTTTAGAAGTAGATTACGATGAAAATGAggtttttgttgaatttgatCGGAATTTAAATAGAGCAAATGAGTGGATACCTATGGATAGCTCTAGATTACGTCCTTATATTGGTACTAGCAATGCAGAATTTGCCGTCGGGGAAAAATGTATGGCTACTTGGATGAATTCTTGTAGTAAATTTCCTgctacaattaaaaaagttcttGATGGcgATAGTTACGAAGTATTATTTGATGAtggttttacaaaaattttaaaacaatgtaaacttacaaaaataaaagatccGAATAATATGCCTCTTGCACCGAAAGCACCTGTACCACATGCTGCACCACTTTTTGAACCAGTTATTGGTTCAAAAGAAGACCGTAGAGAACGCAaacgaaaattaaatgttgCTCAATTATTTGGTCGCAAAAAACCAAAATCTGATGATATGTTTGAAGATGATAAACAATCTGTAGAAGATTTTCCGGCAACtccaactgCACCGACTCTTCCTTATTCAGAAGGGGAAGAATGGACTTGCCGTTGGTTGAATGGCGAACCTATTGGCATTGAATCAACTTTAGAAAGTCCTGATGGACAAAGGCGCTCAATTATTGTTCCAGATCATAGATTACCTACCGGATGGGAAAAACATTTAACTCAAAGAATGTACGGGAATTCGGCTGGAAAATGGGATGCTATTTTAGTcaaTCCCGATGGTAAAAAGTTCGCAAATcggcaacaaataaaaatgtggtTTGAAGAAAACAAACAAGAATTAAACCTAGAACAATTCGATTTTTCTTTGCATATAAATCGCGCTAAAAAATTAGGTCTATACGAAATTACTGATCCGGAATTGACTGCATCTATTTTAAAGCCAACACCAATGCAAAAACCTCCAGGAGCTAAATCTAAAGGTACAACAAAAGCTCAAAGCACTAAACTTTCAACACCGAAAGGTACCAGTAATGTGGCATTACCTACTACACCAGAAACGCCTGTTCATGAATCTGAAATCGAAGAGGAAACtgacaACGCAggaagtttaaaaatactcCACGAAAACGATAGTTACAAGTGTCCGATAGAAGGATGCGGTAAAAATTTTCGTAAGGAAAATTTAGCGCAAATGCATATAAAACATTACCATCCagaatattctaaattaatcgGCTCTACACCGAACGTGGCCGATCTAGCGTACGCGAGAACAGTAGGTGAACATATCGACGAAATAATACCACAAAAAACCAAATCCGTATCTTCTCCGcttattgaaaaagaaaaacctATTAAAACAGAATCCACCCCGAAACCAAAATCaacaattaaagtattaactCCGAAAACAACAGCTAAAGACGATACAAAAGCAGTTGAACCATTACAAAGTATTAATATCCCTAAACCTGTTTCGAAAGATTCCGAAATAATTCGTTTATTAAACAGCGAaccaaaaagtaaaattgattCTATTTTCGATTCAGTTGAACTTCATAAACAGTTAACATCTGAAGAGCCACTAAATCCTGGAGAAAAATATCCAGAAATAAGACTGCGcgatttattgaataaagcTGAACCGATTCCTATTAAAAAGGATGAAAATTATAGACCACCGGGTATAAAAACGTTACTTCCAGTTCATAGAAATACAGAAGAACCTAAAATGGAAGTTGATAGTGATGCAGATAAACCTTATTTATCTGTGAAACAAGATAAAGGTAAAGCACATAGAAAGCGACAATCTTCAGATAGTCGAAGACGGCAATCATTGAAATATGATACAGATGAAATGTCTGATTATTATGAGGCTGATAGTAGGTCTCAAGATTCGTTTAAAGGGAAGACTCCTGTTGAAACACTTCCACCACCTCCTCCGCAAGAGGGGCAGGTTATTATTGAAGGAGGGGAAGTTATTCGATTGGTCCATATGCGAAGcgaagaaataataaactgtACTTGCGGTATAACTGAAGAAGATGGCCTTATGATACAATGTGAGTTATGTCTTTGCTGGCAACATGCTCATTGCAATAACATCGCGAAAGAAAATGAAGTTCCagataaatatgtttgtaaaatttgtaaaaacccGCAACGAATGCGTCAATCGAAGAAATACGTACATGACCAAGAGTGGGTAAAACAAGGAGTACTTGCAACTGCGAATTATCACTCGAAAGATGAAAAATTACTTGAGAAACGTTTTGAATTACTTCGAAAGTCCCATGAACTTAGCGGTTGTATGGTAGAATTAAATGAGTATCTTCATAATTTACggattaaattgaatattgctGGGAATAAAGACCAccctaaattatatttatgggcTAAACAATGGGACAAACCTTTACCAGACAATACATTAAACTTACAAAAACCTGACTCATTAAAACATGACAAAAAGGACGAAAACTTTAACAGAAGTTTTACAAGTTCTGATCATAGTTATATTAAAGGCTCGACATTCAGTGAATTagctttaaaaacaatgttacAACCAGAAGAAATAAAACCCGAAATAAGCACATCAGAAATCGACTTGAAATTAGAAGACACTAAGATAAAATCCGAATcagaattaatatcaattttagaaGACAACGAACCATCAACATCAACTTCAAACcctgaaataaaagaagaaaatgatGATAATCCCGAATTTCCGAAAATCgatttaaattcaatgatcgttaataatttaactgatAAAATAGATCCGAAAGATGAAGTTTTAACTAAAGAAGAagctttaaattcaattacaaGCGGAATCTTAAGTACAAGTTCATTAGACTTAGCGTTGAGTCAAAGTGATTTAGAGAGATTATCAACGCTTGCTCAATTGAGCGGTGTTGTTTCAGCACAGGATGTGACTCAACAAATACATATACCACAACCGGAAGCTGTTATTGATTCTGCTGATTGTAGATTGAACTTGTTAGATCATGTTACACATTATCAAAGTCTTGTTGAGCAAAGATTAAACGCCGTTGAAGCTGCATTATGCGaattggAAGAAGAAGATCCAAGTGCTATATTAGATGATGatgaaactgaaattaaaacaaaacaaacgcTACAAATGCTTATTAGAGATCTTGGTACTATGCGAGAAATTGcagctttaaataattaa
Protein Sequence
MGRKCNVLDCPSDSKRPEDNGVTFHKMPFHPDLRPKWIELCRIPEDRQLNKVIYVCSRHFRRTDFCNFKGTKYMLRQGALPSVFPWTRSFIKISSKCSTSGDESKSSETSDIKTEPMDTDSKSNDDLEMPKIKEEPMDEDDFKPKIKDNDKPPKIKKEVDDKPIKIKKEGDDKPPKLKRENIIVKKENDTPAALPPKLKDETPISINFCAGTRIEANDFNDKWYPATILEVDYDENEVFVEFDRNLNRANEWIPMDSSRLRPYIGTSNAEFAVGEKCMATWMNSCSKFPATIKKVLDGDSYEVLFDDGFTKILKQCKLTKIKDPNNMPLAPKAPVPHAAPLFEPVIGSKEDRRERKRKLNVAQLFGRKKPKSDDMFEDDKQSVEDFPATPTAPTLPYSEGEEWTCRWLNGEPIGIESTLESPDGQRRSIIVPDHRLPTGWEKHLTQRMYGNSAGKWDAILVNPDGKKFANRQQIKMWFEENKQELNLEQFDFSLHINRAKKLGLYEITDPELTASILKPTPMQKPPGAKSKGTTKAQSTKLSTPKGTSNVALPTTPETPVHESEIEEETDNAGSLKILHENDSYKCPIEGCGKNFRKENLAQMHIKHYHPEYSKLIGSTPNVADLAYARTVGEHIDEIIPQKTKSVSSPLIEKEKPIKTESTPKPKSTIKVLTPKTTAKDDTKAVEPLQSINIPKPVSKDSEIIRLLNSEPKSKIDSIFDSVELHKQLTSEEPLNPGEKYPEIRLRDLLNKAEPIPIKKDENYRPPGIKTLLPVHRNTEEPKMEVDSDADKPYLSVKQDKGKAHRKRQSSDSRRRQSLKYDTDEMSDYYEADSRSQDSFKGKTPVETLPPPPPQEGQVIIEGGEVIRLVHMRSEEIINCTCGITEEDGLMIQCELCLCWQHAHCNNIAKENEVPDKYVCKICKNPQRMRQSKKYVHDQEWVKQGVLATANYHSKDEKLLEKRFELLRKSHELSGCMVELNEYLHNLRIKLNIAGNKDHPKLYLWAKQWDKPLPDNTLNLQKPDSLKHDKKDENFNRSFTSSDHSYIKGSTFSELALKTMLQPEEIKPEISTSEIDLKLEDTKIKSESELISILEDNEPSTSTSNPEIKEENDDNPEFPKIDLNSMIVNNLTDKIDPKDEVLTKEEALNSITSGILSTSSLDLALSQSDLERLSTLAQLSGVVSAQDVTQQIHIPQPEAVIDSADCRLNLLDHVTHYQSLVEQRLNAVEAALCELEEEDPSAILDDDETEIKTKQTLQMLIRDLGTMREIAALNN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01229777;
90% Identity
iTF_01229777;
80% Identity
iTF_01229777;