Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.072 5.9e+02 2.3 0.0 25 36 132 143 118 154 0.70

2 5 1.8 1.5e+04 -2.2 0.0 25 45 162 182 155 189 0.72

3 5 0.0014 11 7.8 0.2 22 48 187 213 180 217 0.85

4 5 4.3e-05 0.35 12.6 0.0 21 52 214 245 210 246 0.89

5 5 0.005 41 6.0 0.0 21 48 242 269 240 271 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.072	5.9e+02	2.3	0.0	25	36	132	143	118	154	0.70
2	5	1.8	1.5e+04	-2.2	0.0	25	45	162	182	155	189	0.72
3	5	0.0014	11	7.8	0.2	22	48	187	213	180	217	0.85
4	5	4.3e-05	0.35	12.6	0.0	21	52	214	245	210	246	0.89
5	5	0.005	41	6.0	0.0	21	48	242	269	240	271	0.89

Coding Sequence: ATGGACTCTAGAGATGATTGTGACGAATTTCACTCTTCTCTGGAACCAGttgtaattattaatgatgaaGATGTGGAGGATGAAATTttcaataataaaaatgaagatgAAAGTGATGATTGTGAAACAGATCCCTTATCAATGGAAAATTCAGGAAAAGATGACATTATAAATTCTATAGGCCCAGAAATTTCTATTATACCTGTGAAGAAAAAAAGACCTCAAATAAAGATTCGATTATTTCAAAAAGAATATTCACCTTCCAAGGATGATACTAATACTGCGAAAGTACAAAGTTATATCAGAGCCCCCCGTGAGAAAGTGCGTCGTGTCTCTCAGGATGAAGCTTTAAGTGCAGAAGATACCTATGCGAAACGTAAATCTCACCCTCTAGAGAAATGCCCTATATGTAAAAAGTACTTCCGTAGAATGAAAACTCACTTACTTAAGCATGAGATGATAAGTCGGGCTCCAGAGGATCGCCTGTCATGCTCCTACTGCATGAAGGCGTTCAACACGCAAAGCAACCTGGCCATACACATGAGAACACATACAGGGGACAAGCCTTATGTATGTGAGGTGTGTCAGAAATCATTCTCACAGTCGTGTAACTTGGTGAACCACATGCGGGTGCACACAGGTGAAAAGCCTTTCAAATGTCCTCACTGTGACAGAGCCTTCACTCAATCCGGTAACTTGAACAATCACATTCGCCTGCACACAGACGAGAAGCCTTTCAAATGCCATTTTTGTGACAAAGCTTTTGTACAGTCCGGTAACTTGAGTTCTCATATTAGAAATAACCATAAGTATGATGATAATTCGATTGAAATTATATTGACCTCTCAATAA
Protein Sequence: MDSRDDCDEFHSSLEPVVIINDEDVEDEIFNNKNEDESDDCETDPLSMENSGKDDIINSIGPEISIIPVKKKRPQIKIRLFQKEYSPSKDDTNTAKVQSYIRAPREKVRRVSQDEALSAEDTYAKRKSHPLEKCPICKKYFRRMKTHLLKHEMISRAPEDRLSCSYCMKAFNTQSNLAIHMRTHTGDKPYVCEVCQKSFSQSCNLVNHMRVHTGEKPFKCPHCDRAFTQSGNLNNHIRLHTDEKPFKCHFCDKAFVQSGNLSSHIRNNHKYDDNSIEIILTSQ

Sequence clustering based on sequence similarity using MMseqs2