Pnob051515.1
Basic Information
- Insect
- Poecilobothrus nobilitatus
- Gene Symbol
- -
- Assembly
- GCA_947095535.1
- Location
- OX352773.1:210892270-210894610[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 0.26 1e+03 1.5 0.0 39 99 81 141 63 148 0.82 2 5 3.9e-07 0.0015 20.3 0.3 23 111 167 256 147 266 0.82 3 5 1.7 6.6e+03 -1.1 0.2 20 71 317 368 306 402 0.65 4 5 0.024 95 4.9 0.1 18 83 429 495 415 515 0.80 5 5 1.7e-06 0.0066 18.3 0.2 14 110 518 616 511 626 0.85
Sequence Information
- Coding Sequence
- ATGTCAGAAGATCATTATTTTCGTGATACCGAAATAAATAACATTTCAACTTCACAAATTATAAAAAGATATAAGAATAATAGGGAAGAAATGATTCAAAAAAGTTTGGATGAAGACACTAAAGAATTTCTAATTTTAAACATTTTGAAAGTGGAAGATATAGCTGAAAGTAATTCAACAAAACCTCCAAGCGAAATAAAGTTGAAAAAAGAAGATGAATCTGGTGATGCGATAGTTGATTCGACTTCTGTTTTAGAAATGAATAACTATTGTACTAAAAATATTATAAAAAAACATAACAAAAATGTTGGGATGCTGGATGATACATATTTGAATAGTTATAAGGACATTGAAGCTCCAAATATTGTTAAAATTAAAGAAGAAATTGTTGAAAATTGTCCTTTAATAGAGTCAGACGAAATTATATTGGAATCAGATGATAAATCGCAAATCTTCATTGATTGTTTAAAGCTTCGCCCAAAAATTTCTAAAGAAAAAAAGGAAATTTTAATTAATTTGCATAAATCTGGCATGCCGGTTGTTAAAGCTGCTGCTGCTGTTGGAATAAAAAACAGTACAGCTAATACTATAATAAAAAGATATAAGGAGGATGGAGAAAAGTTTTTTACAAAGCGTTGGGGTGGTCATAGAAAAAAACTTCGAACTCAAAAAGTTTTAGAAACTATAAAAGAAATAGTTGAAACTAATCCTTCCATAACATTACATAAAATTCAAAAGGAGTTGATAGAAAAAAATATTTCTCTGAGTAAAACTTCTATTCATACAGCTTTGAGTCATGATTTAGAAGAATTGATTGATCGTAGGAAAAAGCATCGCGCTTCAAAGATACTGAAAATTAAAGATGAAGGAATTATTGAACGCAATTCTCATGCGAAAGGAAATGAAAAAAATTTAGAAATAAATAGAAAAGGTAATCCAAGTATTTCTAATGAGAAAAAGGAAATATTAATAAATTTGTATGAATCTGGGATACCAATTGTTAAAGCTGCTAATGCTATGAAAATAAATTGTAATACAGCCCATAGTATTATTAGAAGACATAGAAAGGAAGGAGTGGTTGCTAGCAAGCTTTGGGTTTGTAATAATAAAAAATTTAAGGTTGTAAAAAAGTTGGAAACTAAAGAGAAAAATGATGCATGCCAATCTCCTAAAAAGAAAAGTAAAACTTTATTTGAATCGGTAGAAAAAGGTATTATTTTTAAAATGTCTTTGTTTCTAAATATTAATATATATGTACTTACAAAAGTTGAAGGTCGACTAAATATTACTAAAGAACAAAAACAAAGGTTAATTAATTTGTATAGATCTGGCACGGCTATTGTTAATGCTGCTAAGATAATTGGAATAAACTGTAATAGCGCTAATTCTATTATAAAAAGATACAGGAATGACGGAGAGAAATTAATTGAAAAACGATGGGGTGGTCATAAAAAGAAATCGCAAGCTGCAAATATGTTGAAAACTGAAGAAGAAAAAGTTGAAAATCATCTTCCAATTACGGAAGATCAAATTGAATTTCAGTTAGATGTGAAAGGCCGTCAAAGTATTTCTAATACCAAAAAGATGATGTTGATAGACTTATATAAATCTGGAACGTCAATTGTTGATGCTGCTAACTATGTCGGAATAAAATGCAATAGCGCCAATAGTATTATAAGACGATATAAAAAAGATGGTGAGGAATTTATTGTAAAGCGTTGGGGAGGTCATAGAAAAAGACTTCGAACTCAAGAAGTGTTAAAAACAATAGAAGAAATGGTTAAAACTGATCCTTCTATAACCTTACATAAAATTCAAATGGAATTGATACAAAAAGGTATTTCTTTAAGCAAAAGCTCTATTCATAAGGCTTTAAATGATGATTTAGGAATTTCAACAAAATTAGTTCGATGTCGAATGGAAAGTTGTACATAG
- Protein Sequence
- MSEDHYFRDTEINNISTSQIIKRYKNNREEMIQKSLDEDTKEFLILNILKVEDIAESNSTKPPSEIKLKKEDESGDAIVDSTSVLEMNNYCTKNIIKKHNKNVGMLDDTYLNSYKDIEAPNIVKIKEEIVENCPLIESDEIILESDDKSQIFIDCLKLRPKISKEKKEILINLHKSGMPVVKAAAAVGIKNSTANTIIKRYKEDGEKFFTKRWGGHRKKLRTQKVLETIKEIVETNPSITLHKIQKELIEKNISLSKTSIHTALSHDLEELIDRRKKHRASKILKIKDEGIIERNSHAKGNEKNLEINRKGNPSISNEKKEILINLYESGIPIVKAANAMKINCNTAHSIIRRHRKEGVVASKLWVCNNKKFKVVKKLETKEKNDACQSPKKKSKTLFESVEKGIIFKMSLFLNINIYVLTKVEGRLNITKEQKQRLINLYRSGTAIVNAAKIIGINCNSANSIIKRYRNDGEKLIEKRWGGHKKKSQAANMLKTEEEKVENHLPITEDQIEFQLDVKGRQSISNTKKMMLIDLYKSGTSIVDAANYVGIKCNSANSIIRRYKKDGEEFIVKRWGGHRKRLRTQEVLKTIEEMVKTDPSITLHKIQMELIQKGISLSKSSIHKALNDDLGISTKLVRCRMESCT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -