Basic Information

Gene Symbol
-
Assembly
GCA_950381575.1
Location
OX494455.1:9009391-9012090[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 0.42 36 5.8 0.2 1 20 159 178 159 180 0.94
2 20 2.3e-06 0.00019 22.4 1.2 2 23 188 209 187 209 0.97
3 20 0.5 42 5.6 0.7 2 23 213 233 212 233 0.94
4 20 0.015 1.3 10.3 1.1 1 23 238 261 238 261 0.97
5 20 0.36 31 6.0 2.2 2 19 269 285 268 288 0.89
6 20 0.93 79 4.7 1.0 2 23 320 342 320 342 0.91
7 20 0.0009 0.076 14.2 1.7 1 23 348 371 348 371 0.97
8 20 0.021 1.8 9.9 0.2 1 21 375 395 375 396 0.94
9 20 0.0034 0.29 12.4 0.6 1 23 404 427 404 427 0.96
10 20 0.0097 0.82 10.9 0.7 1 23 431 454 431 454 0.95
11 20 9.3e-05 0.0079 17.3 0.1 2 23 467 488 466 488 0.97
12 20 0.00076 0.064 14.4 1.3 1 23 494 516 494 516 0.98
13 20 0.026 2.2 9.6 0.4 2 23 522 542 522 542 0.97
14 20 7.1e-05 0.006 17.7 0.6 2 23 548 569 548 569 0.97
15 20 0.88 75 4.8 0.2 2 23 574 594 573 594 0.91
16 20 7.5 6.3e+02 1.9 3.2 2 23 613 634 612 635 0.93
17 20 4.8e-05 0.0041 18.2 3.1 1 23 641 663 641 663 0.98
18 20 0.00076 0.064 14.4 0.9 2 23 670 691 669 691 0.96
19 20 0.092 7.8 7.9 0.8 1 23 697 720 697 720 0.93
20 20 0.035 3 9.2 1.6 2 23 726 748 726 748 0.95

Sequence Information

Coding Sequence
ATGAAccgttttaaagaaaaattaagcAATATTCTCCATTGCACTCAGTTTTGTGGGCTTTGCAtagaaaaacaagaaaatattagcGCTCTTGATGATAGCTTCCAAATAATTGATGATGGAGAGTGTTATAGTAAAACATTGAGAGAAATAGTCgaggttgtttttaaaaaaCctgaaaacatattaattgactcccaaatatgtaatatttgttCAGAAAAACTAATTCAGTCATACATCTTCATTAAGAATGCTGAGGATTCATCTGAAATGATGAAGCGCTACATAAATGACCTGTTCACTAAATCAGATGATATAATCAATCATATAACTAATGCAAGTTTAGAAAGTTCAAATGTTGTAATTGTACTGGAAAATAGTATTCCTGGCTGTAATGATAAAGATAGTAAACCAAGAACTGTAATAAAAGATGAGATGAAAAATGATGTTCCAAATccaataaaatctaaatttaaatgTCTGAACTGCAATATAAAACTACCCTCATACAGCGCATTAATGTTACACAAAGTAAAATGTCAAGAAACATGCTTGTTACAATGTGAAGAATGCTTTAAGACATTTAGCAACAAACAATACTTAAATGCTCACTACAGAGTTCATTCTAAAGTAAAATGTAAGGTGTGCAATGAACTAATTAGGAGTAAGAAATTAATCGATCATATGAAGAATCATAGTGATTCTTTGCACAAGTGTGTACAATGCAATgaagattttatttcttttaatgctTTACAAATCCATGAAAAGATGTACCATTCAGAAAAAGTTGAGAATTCTCAATGTTTAATGTGTTTTAAGAGTTTTACTCAAGAAGAATTGCAACTACATAACTGCAAGTATAATTGTCCGGAATGTTCTGAAATTCCATGCATGCATTACaagtatttaatgttttatagagAACAGATGTGTAATAATGCTTTGAAAGCAAAATGTTTGGACTGTGATTATGTCTGTAGGAAAAAGGAGATCTTACTAGGGCATGTTAATCGGGAACACTTGGACCACCATCCATATTCTTGTGATAAATGCGGACAGCAATTTTACTCCAAATTGGTCTTAAGAACTCATATACAAAGGTTCCATGGAGataattttgtttgtcagtACTGTGATTCTGAATTCAGTAATGTGAATTCTTATGAGAACCATGTCAATTCTTGTGAGGATATCAAAAGAATTTTTGCATGTAAAGATTGTCCTGCATCTTTTGATTATTATAAGAAACTGATTGACCATGAAAAACGTAGACATAGCATTATTTTCCCATGTGAATTGTGTAATAAAACATTTCTCAAAGAATCTAAAATGAAAGAGCACATGGTCAAAGTTCATAGTggcattcaaataaaaaacaaagttttgaaTGTAGAATGTGTTGTTTGCCAAGAAAAGTTTGACACGAAAGGTGATTTAGTACAACATATGAAATCTCATGGTCCAAATGTAACATATCCATGCAAGATTTGTAATACAGAGTATGAGACACTAAGACAGTTTCGCGCGCATAATAGAAAACATGGCGGCCCATTTGCAACTTGTGAAGTTTGCGGTAAAGAAATGCGAGCGATACTTCTAAAGAAACATATGACTACCCATAGGGACAGTATTGAGACGTGCGAGACTTGTGGCCGGTCGTTTGCCAACATAACATTACTGAAATACCACCAAAAAGTTCATTTAGAAAGTATGCCTTGTCCAAAATGTAAGAAGTTGATAAACCCGGCGCGATTAAGGAGACATTGGAAAGGACATCTTATTGAAGAGAATCCGAACTTAAAAGgagcaaaaaaacaaactcctAAATTGAAATGTGAACAATGTGACTACATAACCTGGAACAACACACTTCTCGAATGCCATATGAATCGTCATCACTTAAAGATCAAGCCCTATGTTTGTCACGTATGCAGCAAAGACTTTATTGGCAAACATTTGCTAAAAAAACACATAGAAACACATCAGTTAGACAAATCCGTCGTTTGCATGGTGTGTTTGAAAAGTTTTGCAAATTCTGCGTGTTTAAAAATGCACTTACGTTTGCATACTGGCGAAAAACCTTTTACTTGCGACGTATGTGGCGATAGATTTCGATCTTCAAGTATAATGAATGTTCATAAGTTGAAGAAACATTCGGATAAGAGTAATACGTGTCCGTTGTGTTCGAATAAGTTTCATACTGTGAGGGATTTGAGGAGGCATGTGATCAAAGTGCATTGGAAACAGAAGAATAAGCGGTTTGATCCGAGAGAGCTGAAGGGTTTAGATAAGGAGCATTATCACTTGTTTCATGATGGAAGGAGGGTCAAAGTCGCTGAGGAAGATGTCGATTTTTATATGCCGTGTTGA
Protein Sequence
MNRFKEKLSNILHCTQFCGLCIEKQENISALDDSFQIIDDGECYSKTLREIVEVVFKKPENILIDSQICNICSEKLIQSYIFIKNAEDSSEMMKRYINDLFTKSDDIINHITNASLESSNVVIVLENSIPGCNDKDSKPRTVIKDEMKNDVPNPIKSKFKCLNCNIKLPSYSALMLHKVKCQETCLLQCEECFKTFSNKQYLNAHYRVHSKVKCKVCNELIRSKKLIDHMKNHSDSLHKCVQCNEDFISFNALQIHEKMYHSEKVENSQCLMCFKSFTQEELQLHNCKYNCPECSEIPCMHYKYLMFYREQMCNNALKAKCLDCDYVCRKKEILLGHVNREHLDHHPYSCDKCGQQFYSKLVLRTHIQRFHGDNFVCQYCDSEFSNVNSYENHVNSCEDIKRIFACKDCPASFDYYKKLIDHEKRRHSIIFPCELCNKTFLKESKMKEHMVKVHSGIQIKNKVLNVECVVCQEKFDTKGDLVQHMKSHGPNVTYPCKICNTEYETLRQFRAHNRKHGGPFATCEVCGKEMRAILLKKHMTTHRDSIETCETCGRSFANITLLKYHQKVHLESMPCPKCKKLINPARLRRHWKGHLIEENPNLKGAKKQTPKLKCEQCDYITWNNTLLECHMNRHHLKIKPYVCHVCSKDFIGKHLLKKHIETHQLDKSVVCMVCLKSFANSACLKMHLRLHTGEKPFTCDVCGDRFRSSSIMNVHKLKKHSDKSNTCPLCSNKFHTVRDLRRHVIKVHWKQKNKRFDPRELKGLDKEHYHLFHDGRRVKVAEEDVDFYMPC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00186556;
90% Identity
-
80% Identity
-