Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.36 1.5e+03 -0.7 0.0 6 14 5 13 3 30 0.74

2 4 2.3 9.7e+03 -3.2 0.7 59 63 48 52 43 56 0.62

3 4 2e-17 8.5e-14 51.4 3.9 4 70 100 166 97 166 0.96

4 4 0.14 6.1e+02 0.6 0.1 5 15 171 181 167 188 0.59

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.36	1.5e+03	-0.7	0.0	6	14	5	13	3	30	0.74
2	4	2.3	9.7e+03	-3.2	0.7	59	63	48	52	43	56	0.62
3	4	2e-17	8.5e-14	51.4	3.9	4	70	100	166	97	166	0.96
4	4	0.14	6.1e+02	0.6	0.1	5	15	171	181	167	188	0.59

Coding Sequence: ATGGGATCGGCTGTTATTTGTCAGATATGTGGTGAAAAATTTACAGTACTAAATGAAACTGAACGTGCAACCATATTAGGACAACATTTAATGGAAAAACATCCATCTATTGAAATGGCACATTTCTCTAAAGATAATTTATGTCAATGTTGTACAGAAGAAGAAGATTTATCAaaaaagcagaaacaaaatgaaagtttgaaatcaccCTGTAGCTGTCCAGCAATAGAAAATCAGAAAAAGCCTCGTTCGTCTTGTATTTTTAAAACTACAGTTGAAACTTGGAGACAAGCTACCGTACGTGTACTATGTCCGAAATGCAACACATTAGATCGTCCATGTATAAGGCGACAAAGAAATAGAGTTGCCCATTCCCCATTAGGAGCTCTATGCCTTTTAATTTGTTGGCCAGTTTGTTTTCTACCATTTCTAATGCCACAAGGCAATCGAATCGATTTGTTTTGTAGAAATTGCGGCGtatttttagGTCAATATGACaaaaagaatggaaaattgaaatgCCCACCATGCCCAGCAGTAGTAGTTGAAGACATCAATGTTCACACTTTACCAACATTGgcttaa
Protein Sequence: MGSAVICQICGEKFTVLNETERATILGQHLMEKHPSIEMAHFSKDNLCQCCTEEEDLSKKQKQNESLKSPCSCPAIENQKKPRSSCIFKTTVETWRQATVRVLCPKCNTLDRPCIRRQRNRVAHSPLGALCLLICWPVCFLPFLMPQGNRIDLFCRNCGVFLGQYDKKNGKLKCPPCPAVVVEDINVHTLPTLA

Sequence clustering based on sequence similarity using MMseqs2