Pors027129.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Platygaster orseoliae
Gene Symbol
MBD-R2
Assembly
GCA_030522825.1
Location
JAPYZL010093628.1:7367-16133[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 9.3e-17 6.6e-13 49.7 0.5 6 75 340 409 335 411 0.92
2 2 5.6 4e+04 -4.1 0.0 43 61 1023 1041 1022 1043 0.76

Sequence Information

Coding Sequence
ATGAAAACCTCATACCCCCAAGAGGATATGGAATTCATAAATAACGGAATATCTGAATTCGACTTATCTGCTTCTGACGCTAATGTTAACAACATTAACAATGCGGAAAAAACTCCAGCCTGTATCCACCAGGgaaacaatactgaaaaaaatgaagagaaaaaacaaataaataacaatcaaaaagtgTTGAATTTCACTCCTGGAGCTCGATTGGAAGTGAAAGATTTCAGTGAAAAATGgtACGCCGCACGAATTGTAGAAACCGATTATGTTGAACGAGAAGTGTTGATTCACTTTGAAAAATGGAGTGCAAGTTTCGACGAGTGGATCTCGATGGACAGTTGCAGGCTACGAGCAGCTCAAGCTCAGCCCAAGTTGCGAGTTGTGCTACCGAAATCCGTTCAACCAAGTGAAGTGCAGAAACCTTGGACACCACCACCTCCGGAACCCAGCAAAACCAAGGAATTCGTCGTTGGCGAAAGAGTTCTGGCGACGTGGGGCGATGGAAGAAAATATCCTGCCCATATCAGCAGTGTCTTGGCTAATGGTCGTTATGATGTTTTGTTTGACGATGGGTACGCCAAAGTCATCAAAGCATCGAAGATTGTGAAAATGTCTGGCACTGCTGATAAGtatcTGGTGAATGATTACATAGGAAGCAAACAAGAACGAAGAGACAAAAAAAGAAAGCACTCGGTGATGGAATTATTCAATAAACACGCCAAGAAAAAACCACCGCCTGTGACAGAAAGGTTGAAAAAAGAGGATGAAAAAAATGGCCAAGAAACGATGAATATTCAAGTGAAAGAAAAAACCTCAGCCTTTAATACCATGGCAGAAAACAATGTCAACAGGAATTCGCAAAATTTGGAGTCAATAAAACAGGAAGAATTGAATTACGATTTGGATTATGACGAAGAAATAGGCACTAGATGGATCAATGGAGAACCTCAAGGGATCGAAGCTTTTATTCAAGAAGGGAGCGATGGTCGAAgtcCTCGAAGATCTATAATTGTCTATGACAAAAGACTTCCTCCTGGTTGGCAAAGACATTTCACCCAAAGAAGAACTGGCTGTTCTGCTGGAAAATGGGACGTTTTTTTTGTACATGAGAAAAGCGtgaaaaaatttcgttcaaaAAGTGAAATCAAGATGTATTTGGATAGCATGGGTGATTTTGATTACGATATGGGACAGTTTGACTTTTGTGCCCGTCGAAAGAGAAAAGTGGCGCCTTTTTCAAAGATGAAGAAcaattcagaaatgaaaaaaaaccagACCTTTATGCCAAAGAACAACTCTTCAGGTTTTCATGGTGCTACCGGATTGACGCCAGAATTTTCGCATGCCGACGATAATGCTGTTTTCATCGGCACCCTTCGAGTTGAAATAGAAAACAGTGCATACAAGTGCCCCAAGGAAGGCTGTCACAAACAATTTCGCAAAGAAAATCTACTGCAGATGCACATCAAACATTACCATCCTGAATATTCCAAGTTTTTGGGCTCGACACCGAACGTCGCGGATTTAGCTTACGCGCGAACAATCGGAGAATCCGTTGACGGCATTACTCCGAAAAAGCATTCATATTTTTCGGATCGCCCAAAGTTGGACAGGCGAAAGGAGAAAACGCCTTTGGCCCCGGTTTTGTCTCCTATGATGAACCAAATGCCGCCCGTCATTAGAGACTCGTCGATTTTGCCACCGGTGTTGGAAGCGGAAGgaacaaaaaaagatttgaagGAATCGTTTGTCGATTCCAGCATTCGAATGGGTATAGAAAATGATCCGGGACATTTCGAAACCGAGCCTCTTTCTCCAAATACagcttttcacaaaaaaatgagcAAAGGAGAAAAGGCTTTTTCAGGTCTCAGGACCTTATTCCCGGTAAGGCACGAGGACAAAGCGAAAACCGAGGAGAAAAAAAAGACGTTCTTCGAACGCGAAAatccaaaacaggaaaaatgGCAAGaCACGTTGGATTACGAGTTAGCTGATGATGACAGCACATTAGACACGGACAAATCGTCATTTTCTTATCGGTTCAGCAAGATGAAAAATAGTCCACTTATTGAAAATCGCTTTGACAAAGTCACCGCCTTAAAAGGAACAGATTCAGATAAGAAAACTGATAATGATATTGAAGAAAAAGaggGACCATCGACAATGATGATCAATGGTGAGCTCGTGAAATTGGAGCGACTTCGTCGCGAAGAGATCATCAATTGCACTTGCCGGATCATGGAAGAGGATGGTCTAATGATTCAGTGCGACGTATGTTTGTGCTGGCAGCATGCTTATTGTAGCGGCGTTGACAGCGAAAGTCAAGTTCCTGATAAATATATCTGCAGTATCTGCCAAAATTCGTATCGCCAGAGGCCTTCGAAAAAATATGCTCACGATCAAGAATGGATCAAAGAAGGAAAATTGCCGAGTTTGCCTGGCAGAGCTAAAAACCAACAGAAAATGAATCTGCGAACAGCAGTCCTCAAAAGATGCTTCGATTTGGTTAATGCACTTTTGCAAATTCAAGAAGTTTTGCACAGTTTGCGTGTAAAAATCAACGTCGCCAAAGAAAAGGATCATCCGAAGCTGTATCTTTGGGCAAAAAATTGGCCAAAGATAGGCATCCCAAAAGTGGACACCGAACCAGTTCCAGTGATGAAGTATGAaagatccaaaaattttaaaaacggaTTTTCTCAAAACGACGAATTGCTTTTTGATGCGGTGAACTCCAGAAATGGTTTTGAGAAAACCATCACTTCGAATTCAGAGCTGATGACAATTCTGGAAGGTGATAACGCTTTGTTGGAGAATCCATTTTTCCACTCCAATAATGAGAATGACATGGATGTTCTAATGAAAGATGATACCACACAAGATACACAAACTGGATCATCAAACCAGTCGAGTTTTCACATGAACTTTGCCAATGAACAAGCCCATGCACCGCCTCGGCCTGTTGCCCCTGAACCAGAGGCACCAATCGATCCAATGGAATGCAGGATCAGACTTTTGGAGCACATCAGGGATGTGCAAATTCACATCGATTTAAGATTAAACTCTATCGAAACACAAATAACATATTTGGAAGAAGGTGGGGACTATACCGAGCCATCTGACCAAGGCCTACTACGAAACAAGCAAACTGTGCAGATGTTGCTTCGAGATTTGTTAACGATTCGCAAGCTGGCGGCTtccttttga
Protein Sequence
MKTSYPQEDMEFINNGISEFDLSASDANVNNINNAEKTPACIHQGNNTEKNEEKKQINNNQKVLNFTPGARLEVKDFSEKWYAARIVETDYVEREVLIHFEKWSASFDEWISMDSCRLRAAQAQPKLRVVLPKSVQPSEVQKPWTPPPPEPSKTKEFVVGERVLATWGDGRKYPAHISSVLANGRYDVLFDDGYAKVIKASKIVKMSGTADKYLVNDYIGSKQERRDKKRKHSVMELFNKHAKKKPPPVTERLKKEDEKNGQETMNIQVKEKTSAFNTMAENNVNRNSQNLESIKQEELNYDLDYDEEIGTRWINGEPQGIEAFIQEGSDGRSPRRSIIVYDKRLPPGWQRHFTQRRTGCSAGKWDVFFVHEKSVKKFRSKSEIKMYLDSMGDFDYDMGQFDFCARRKRKVAPFSKMKNNSEMKKNQTFMPKNNSSGFHGATGLTPEFSHADDNAVFIGTLRVEIENSAYKCPKEGCHKQFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVDGITPKKHSYFSDRPKLDRRKEKTPLAPVLSPMMNQMPPVIRDSSILPPVLEAEGTKKDLKESFVDSSIRMGIENDPGHFETEPLSPNTAFHKKMSKGEKAFSGLRTLFPVRHEDKAKTEEKKKTFFERENPKQEKWQDTLDYELADDDSTLDTDKSSFSYRFSKMKNSPLIENRFDKVTALKGTDSDKKTDNDIEEKEGPSTMMINGELVKLERLRREEIINCTCRIMEEDGLMIQCDVCLCWQHAYCSGVDSESQVPDKYICSICQNSYRQRPSKKYAHDQEWIKEGKLPSLPGRAKNQQKMNLRTAVLKRCFDLVNALLQIQEVLHSLRVKINVAKEKDHPKLYLWAKNWPKIGIPKVDTEPVPVMKYERSKNFKNGFSQNDELLFDAVNSRNGFEKTITSNSELMTILEGDNALLENPFFHSNNENDMDVLMKDDTTQDTQTGSSNQSSFHMNFANEQAHAPPRPVAPEPEAPIDPMECRIRLLEHIRDVQIHIDLRLNSIETQITYLEEGGDYTEPSDQGLLRNKQTVQMLLRDLLTIRKLAASF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01214794;
90% Identity
-
80% Identity
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