Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 8 5e+03 -0.7 0.0 8 44 72 108 66 119 0.77

2 3 1.6e-23 1e-20 75.6 0.1 3 108 161 264 159 266 0.91

3 3 1.1 7.1e+02 2.1 0.1 81 107 269 295 265 297 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	8	5e+03	-0.7	0.0	8	44	72	108	66	119	0.77
2	3	1.6e-23	1e-20	75.6	0.1	3	108	161	264	159	266	0.91
3	3	1.1	7.1e+02	2.1	0.1	81	107	269	295	265	297	0.90

Coding Sequence: ATGCGAGTAAGTAGACATTCATACGATTTAGTGTCTGAAATATCATTCAGCGAAAACACCAAAGAAGTGAAGTTGGAATGTATTTCATCTGAATTACCTGAAATCTTACAGACAAGACTAAAACAAGAATATTACACCATTACAACAAATATAGATGATTTACCAGAAGGTTTTGATGAAGATTGTAAATTGAAGCTTCGCATGAGGTATAGTGACGATTCTGTAGACGTATACTATTTAGCGCCAAGAAGAGTACATATGAAGTGTAATATGTGCATACTATTGGGGTGTAACCCACCAATATCACACCTCTTTGATCATGATTTCATgtggattgaacaaaatatgtGGATTCATTTGGGTGGTAAAAGGTTGCAGCGCAACTTGATTTGTggaataaaatttacatttcaGTTTAcattaacaacaaatatttcacatcATTCCAAACCTCAAAAACGGCTTAGTAAAGATCTCTTAAACCTCCTTGATAATTGCCTGTTTACtgatattacaataatatctaATGATGGTACTGAAATTCAAGCACATAAGGGCATATTAGCTACAAGGAGTGCTGTCTTCAGTGCACATTTTGAGCATGACATGGTTGAAAATAGAACCAATATTATTGAATTCCCTATGAATACTGAAGTGCTTCAAGAAGTGTTGAGATATATATACACAGAAGAGGCTCCTAATCTGAATAAAATGCCAGAAGATCTATTAGTAGCAGCAGATTTTTTCCAGTTGATGAATCTGAAAGATCTTTGTGGGGAAGCATTATGTAAGTTGTTAACAGTGGAAAATGTAATAAAGACTTTAGAACTTGCGAATTTACACTCATTAGAGGAATTAAAACTATCATGTTTCCAGTTCATAAATAGTGATGGTCAAGCAATAACAAAGAGTAAAGGCTGGGAAGATATGAAATCTATGgagttcataaaaaatatagccgAATACTTTATGAATCATCCTCATagtaaatag
Protein Sequence: MRVSRHSYDLVSEISFSENTKEVKLECISSELPEILQTRLKQEYYTITTNIDDLPEGFDEDCKLKLRMRYSDDSVDVYYLAPRRVHMKCNMCILLGCNPPISHLFDHDFMWIEQNMWIHLGGKRLQRNLICGIKFTFQFTLTTNISHHSKPQKRLSKDLLNLLDNCLFTDITIISNDGTEIQAHKGILATRSAVFSAHFEHDMVENRTNIIEFPMNTEVLQEVLRYIYTEEAPNLNKMPEDLLVAADFFQLMNLKDLCGEALCKLLTVENVIKTLELANLHSLEELKLSCFQFINSDGQAITKSKGWEDMKSMEFIKNIAEYFMNHPHSK

Sequence clustering based on sequence similarity using MMseqs2