Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 9e-39 9.8e-36 122.1 1.1 1 88 12 98 12 98 0.97

2 3 5.1 5.5e+03 -2.1 0.1 56 80 128 153 125 161 0.66

3 3 9.1 9.9e+03 -2.9 0.1 36 50 158 171 139 171 0.72

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	9e-39	9.8e-36	122.1	1.1	1	88	12	98	12	98	0.97
2	3	5.1	5.5e+03	-2.1	0.1	56	80	128	153	125	161	0.66
3	3	9.1	9.9e+03	-2.9	0.1	36	50	158	171	139	171	0.72

Coding Sequence: ATGCCGCGGCCTTTAAAAGAAAGTTACGGCGATCAGAAGCCACCATTTTCATATATCTCACTAACAGCGATGGCTATATGGAGTTCTCCACAAAAGATGCTGCCCCTCAGTGACATTTACAAGTTCATAATGGACAAATTTCCGTATTATCGCAAGAATACGCAAAAGTGGCAGAATTCATTACGACACAATCTAAGCTTCAACGATTGTTTCATCAAAATTCCACGAAATACCCAAAAAACGGGCAAAGGATCCTACTGGACGCTGCATCCTAAAGCTTTCGACATGTTCGAAAATGGCAGTTTGCTTCGTAGGCGCAAACGTTTTAGAGTGCAAAAGCTAGAAAAAGAGATGCTGAATGGAGAATTGGCTGCCATCGCCAGTTTCAATCGATTCTTCAtgtcgcaacaacaacaacaacaacctcaTATGGATTTCCAAACAAACTGGAATCTACCATCTGAAGCCAACTACATCACCACAAATAATACACCGCGTACTTGGCAAAGTAGCCCATCACCTGATTATGTCAGCGTTTCAAGTGCGTCAATGTCACCGGAGCCAATCGACGTGCTTCAACAACATGGTCAATCATCTATAACCCTGCCACCAACCAGGCCGAAGCGCCTCTTTACAATAGAAAGCATTATAGGCCCCGAACCGAGTCCTACTGGCGAGCTTAAATCGACAATAATACCGACGGAATTACCGCAAGCGCAAATACCGAATTTGCCATTACAAACATTTAGTCCAGCTAATCTACATTTGTTGGCGACAccacatcatcagcatcagcaaccTGCTCCCAACATCGCCCATCCACTACATCAACAACCAGATCATCATTACAActatcatcaacaacaacaactccagcaacaactccaacaacaacaacaacaactagtaTTATTCCATCACCAACAAATGATGGCTGCGCATGCGCATTATCAAGCTAATCATCAAATTGGTGCAACCCCGGCAATAATGCATGATCCACAAAGTCTTTATCGAAATTATCTCGGGCCTCTGCCGgttttctga
Protein Sequence: MPRPLKESYGDQKPPFSYISLTAMAIWSSPQKMLPLSDIYKFIMDKFPYYRKNTQKWQNSLRHNLSFNDCFIKIPRNTQKTGKGSYWTLHPKAFDMFENGSLLRRRKRFRVQKLEKEMLNGELAAIASFNRFFMSQQQQQQPHMDFQTNWNLPSEANYITTNNTPRTWQSSPSPDYVSVSSASMSPEPIDVLQQHGQSSITLPPTRPKRLFTIESIIGPEPSPTGELKSTIIPTELPQAQIPNLPLQTFSPANLHLLATPHHQHQQPAPNIAHPLHQQPDHHYNYHQQQQLQQQLQQQQQQLVLFHHQQMMAAHAHYQANHQIGATPAIMHDPQSLYRNYLGPLPVF

Sequence clustering based on sequence similarity using MMseqs2