Basic Information

Gene Symbol
topi
Assembly
GCA_030142555.1
Location
JARQTF010000050.1:888540-890810[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.12 8.4 7.1 2.0 1 23 254 276 254 276 0.95
2 16 0.14 9.8 6.9 1.1 2 23 283 305 282 305 0.95
3 16 0.0025 0.17 12.4 0.3 2 21 312 331 311 332 0.92
4 16 1.1e-05 0.00078 19.8 0.8 1 23 339 361 339 361 0.97
5 16 1.2e-06 8e-05 22.9 1.3 1 23 367 389 367 389 0.95
6 16 0.0087 0.59 10.7 0.7 2 23 401 422 400 422 0.96
7 16 0.00059 0.04 14.4 4.1 1 23 438 460 438 460 0.97
8 16 0.14 9.6 6.9 0.2 1 23 466 488 466 488 0.94
9 16 1.3 89 3.8 3.5 1 23 498 521 498 522 0.94
10 16 0.098 6.6 7.4 0.0 1 21 535 555 535 556 0.92
11 16 0.0056 0.38 11.3 0.1 1 23 561 583 561 583 0.98
12 16 2.5e-06 0.00017 21.8 3.1 1 23 589 611 589 611 0.98
13 16 0.00022 0.015 15.7 0.6 1 23 617 640 617 640 0.97
14 16 0.12 8.4 7.1 1.9 1 23 646 668 646 668 0.89
15 16 4e-07 2.7e-05 24.4 2.2 1 23 674 696 674 696 0.99
16 16 7.7e-06 0.00052 20.3 4.9 1 23 702 725 702 725 0.96

Sequence Information

Coding Sequence
ATGCTGAAGGCGGAGTCGATAAGCACGATAAGCGACAGGGACGAAAACTTGGAAGACGACATAGATGATCTCGATGGATCCATAATATGGTCGCAGGACGATCCTCTGTCCTGCAACGAAATTTTAGAAGCGGAGCCGAATATTGGTCCTGGAGGAGATACACTAGGAAGTCCAATCACGTTGTGCCGGTTATGTGCCGGTCAAACTGTAAACccggtatatatttattcggaAATCGGAGAGTCATTGAAACTTGCTCAAAAGATAAACACCTGCTTAAGCATTAagGTAAGAAAGACCGATCCTTTGCCCAAGCAACTCTGCGTTACCTGCGTGGAGAAGATTAACTGGTGCAACGAATTCGACAACGATTGTATAAAAGCCGAGGAAACCTTGACGACTATGCTACGCGAAAAGAGATGTTTTGAAGTATCAGAAATACTAAACAAGGATCAGATTTGCCATAAGTCGTGTCCTTTGTGTCTGGAAGGTCATATGACGACGACTCAATTGAAGACGAACGATCCGACGTTTGAAGAATTGTACGATAGCGATATTGTACTGGACAGTAGTGACGAAGAGAAGATGtttaacgaattaaaaatggaCAAGGAATTCGGGAGCAACGCGATAATGCTTCAATGTCTTGGAAGCAGTCAGCAGTACCTAAAGTGTGGGGCTTGCATGAATCTTTATCACACGAAAGAGACCTTGGACAATCACAAGTGTAAGCCAAACGTCCAGAATACGTCTAAGCCGTATAAATGCCTCATGTGTAATGCCACCTTTACCTTCGAAGAACGATTGAATTTTCACATGCAGTTTCACAAGGGTGTCAAAGCCCTGTATTGCGAAGTCTGCAAAATCACCTTTGGCAAAGAGTTAAAGTTGTTTTACCATTATAAGAGGTATCACTGCGAGGCCATGACGGTGTCCTGTCTGCAGTGCGGAAAACTTTTCGAGAGTCAGGAACAACTCAGAGTTCACGTATGCGTCGATGGGAAGACGAGGCCTCACGTTTGTGAAGTCTGCAACAAGGGCTTCTCCGATGGCTACACCTTGAAGCGACATATAGTAACTCATCTGCCTGAAAAACCATACAAGTGTCCTCAGTGCTCGAAGAGTTTCACGCAAAAATCAAGACTAAATAAGCACGTTGCTGGTCACGGGATTGTTATCGAAAATAGTCAAACCGCCTGGAAATGCGTTCAATGCGGCGAGACTTTTAACAGTTGCGACGAAGCGGATAGTCATTACAAGATTCACGAGGATAAGATCACCTTGATAGAAGAATTATCCACGTCGAAGATGTACCACTGCGAATTCTGCAACAGCCACTTCGTAGACCCTGATAATTTGAAGACGCATCAGAACCAGCACGTAGTCGAAAGACCTTATAGTTGTAATCTTTGTAATACAATTTACAAATCCTTCGCTGAGGCGGTGCTACACTGGAAGGAACATCCTAGAACCTTTAAGGTAGTCACGGTATTCCTCTGCGACCTCTGCAGCAAGGACATGAAAGAGTTGTCCCTGCTGTACAAGCACAAACGGAAGAGACATCATTACGTGCCGAGAAAATCAGAATCCGGCAACGCGAAGTTCATCTGCGAACTTTGCGGCAGTACTTTTGAGAAGAGCGAAGAGATTCAGGAACATGGTAGAGATCAGTGCTCAAAGTTCCCCTGTGATATATGCGGCAGTTTGTTACCAACTGCAAATTCCCTGAATGCCCATAAAAGAAGACACAGTGGTCTGCGTCCTTACGTTTGTAATATTTGTGGAAAAAGTTACACTCAATCCAGTCATATGTGGACGCACAAGAGGTTTCACATGGGCGTGAAACCGTACGCCTGCCAGTACTGTGACCAGAGATTCACGATTAAGCCCGACCTGGCTGATCACACCAGGAAGAAGCACACCAGAGAAAGACCATTTAAGTGCGACGTCTGTCACAAAGCCTTTCTCACTGGGTCTGTCTTTTATCAACATCGACTGATTCACAGAGGAGATAGGCGATACAAGTGTCACTATTGCGAAAAGGCATTCACCAGGACTGAAGCTCTTAACAATCACATTAAGATACACACTGGCGAGAAGCCTCACGCCTGCGATGTATGCGGAAGATGCTTCAGGCAGAAAGGTGACATGAGGAAGCACAGACGTACCCAACACGCTGCCAAGCAAGAACTTTCTTGA
Protein Sequence
MLKAESISTISDRDENLEDDIDDLDGSIIWSQDDPLSCNEILEAEPNIGPGGDTLGSPITLCRLCAGQTVNPVYIYSEIGESLKLAQKINTCLSIKVRKTDPLPKQLCVTCVEKINWCNEFDNDCIKAEETLTTMLREKRCFEVSEILNKDQICHKSCPLCLEGHMTTTQLKTNDPTFEELYDSDIVLDSSDEEKMFNELKMDKEFGSNAIMLQCLGSSQQYLKCGACMNLYHTKETLDNHKCKPNVQNTSKPYKCLMCNATFTFEERLNFHMQFHKGVKALYCEVCKITFGKELKLFYHYKRYHCEAMTVSCLQCGKLFESQEQLRVHVCVDGKTRPHVCEVCNKGFSDGYTLKRHIVTHLPEKPYKCPQCSKSFTQKSRLNKHVAGHGIVIENSQTAWKCVQCGETFNSCDEADSHYKIHEDKITLIEELSTSKMYHCEFCNSHFVDPDNLKTHQNQHVVERPYSCNLCNTIYKSFAEAVLHWKEHPRTFKVVTVFLCDLCSKDMKELSLLYKHKRKRHHYVPRKSESGNAKFICELCGSTFEKSEEIQEHGRDQCSKFPCDICGSLLPTANSLNAHKRRHSGLRPYVCNICGKSYTQSSHMWTHKRFHMGVKPYACQYCDQRFTIKPDLADHTRKKHTRERPFKCDVCHKAFLTGSVFYQHRLIHRGDRRYKCHYCEKAFTRTEALNNHIKIHTGEKPHACDVCGRCFRQKGDMRKHRRTQHAAKQELS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01255863;
90% Identity
iTF_01131009;
80% Identity
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