Pful013418.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Phragmatobia fuliginosa
Gene Symbol
-
Assembly
GCA_932526455.1
Location
CAKOBD010000080.1:4488212-4495741[+]

Transcription Factor Domain

TF Family
DACH
Domain
DACH domain
PFAM
AnimalTFDB
TF Group
Unclassified Structure
Description
This family of proteins includes transcription factors involved in the regulation of organogenesis. Members of this family appear to regulate the SIX1, SIX6, and possibly SIX5 genes, influencing myogenesis and the proliferation of precursor cells in myoblasts. They are known to act as corepressors or coactivators in these processes, depending on their interaction with other proteins such as EYA3, CREBBP, NCOR1, TBL1, HDAC1, and HDAC3. These proteins are also implicated in the repression of cyclin-dependent kinase inhibitors, including the p27Kip1 promoter, which is key in cell cycle regulation. Some family members inhibit TGF-beta signaling through interactions with SMAD4. They are characterized by a conserved DNA-binding domain known as the DACHbox-N or DD1 domain, which is structurally similar to the forkhead/winged helix domain and is responsible for their DNA-binding activity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.3e-12 3.4e-08 33.9 0.8 104 155 47 99 22 117 0.83
2 2 0.026 3.9e+02 1.2 0.1 91 133 168 182 162 201 0.58

Sequence Information

Coding Sequence
ATGGCTAAACGCGAGGTGGTTATTGCCGCTAAGAAAACCTTCAACATTTCTCATATAGAAACTGTTTATGATTTAAGAGTAAAAGAGACAGATGTAACACGAATTTCAGGTTTCACTTGTAGTTATGTAGATAAAGTGAAATATCACAAACTGCTAAAAAAAGAGAAAAAGCAGCGAATGATGATTCAAGAACATCTTGAAATTGAGCTGAAGAGAAGGCATAAGATTGAAGAAGCTTTAAAACAGTCTGGCGCTCCTTCCGAGATACTCAGAATAGTAACAGAGAATCTGACATCATCAAATCAAGACACTCCTCGTTCTGAACGTGAGAACGGATCAGAAAGAGAAAGCAAGCCTCCCAGTGCTGAACCTCCACCAGCTTCACCGCCTTTCCAGAGGGATCCTCCTCGTACGCCGGACAAACCTCAGTGGAACTATCCCCCACCACCTGTAGACATTATGGGCGGAGGAGCTGCGTTTTGGCAAAATTACTCTGAATCCCTGGCGCAAGAGTTGGAGATGGAGCGCAAATCCCGTCAGCAGGCCATGGAGCGTGATGTGAAAAGCCCTCTGTCAGACCGCGCCAGCTACTACAAGAACTCTGTGTTATTCAGTTCTGCTACTTAG
Protein Sequence
MAKREVVIAAKKTFNISHIETVYDLRVKETDVTRISGFTCSYVDKVKYHKLLKKEKKQRMMIQEHLEIELKRRHKIEEALKQSGAPSEILRIVTENLTSSNQDTPRSERENGSERESKPPSAEPPPASPPFQRDPPRTPDKPQWNYPPPPVDIMGGGAAFWQNYSESLAQELEMERKSRQQAMERDVKSPLSDRASYYKNSVLFSSAT