Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 6.6e-13 3.1e-08 36.2 2.7 180 264 30 108 22 141 0.76

2 2 0.27 1.2e+04 -1.9 0.0 1 19 142 160 142 162 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	6.6e-13	3.1e-08	36.2	2.7	180	264	30	108	22	141	0.76
2	2	0.27	1.2e+04	-1.9	0.0	1	19	142	160	142	162	0.89

Coding Sequence: ATGAGCACCGGCGGAGGACGCCGAAGAATCGTGGCAAAGTCTTCGACTGAGGTTGCGAGATTAATATTGTACAGCAGACGGAGGCCCGGTTTAGTGTTTATCGTCGAGGAGGAGACCGTCGAGGACGACGAGGAGAACTGGACGAAGCTGTGCAAGGTACTGGTCAGTACGGAGAACGCCGGCGACGGCAGCTTGGACGTGCAATTGGCGCGGTTCGCGAAGGATCGCGAGGAGCTGCAGGTTCGAATTAGTTACTTAAAGTTAGAGCTAGAGGAGGAGAAGAATAGGCAAAGGAAACAGCGAATCGACGAAAGCGGAACGGGATATGACGAGATTGCAGGCGACTTGATCAGACACAAATCGTCGGCGGAGGTCTCCGAGAAATCGCAGGTAGCCTTAAAACTTGAAAAGCGGAAACTGCACAGTGAGGTTCGAAAGGCACAGAAAAGAACAGGACTATTAGAAAGCAGAACCATAAAAGTTGTGGTTCCGCAAGGAAGCATTTTGGCTCCCATTTTATTCTCTCCGTATGCTCCTGATTTAGTTGAATATATCGGTGGGAATCACTGCACCCTGTATGCTGACGATACCAGCGTCTTGATCTTGAAGGCCTATCAACAACAAACCATAGCCGAAGCGAATAAAACATTGGATGTGCTATATAGCTGGTTTTGCTAA
Protein Sequence: MSTGGGRRRIVAKSSTEVARLILYSRRRPGLVFIVEEETVEDDEENWTKLCKVLVSTENAGDGSLDVQLARFAKDREELQVRISYLKLELEEEKNRQRKQRIDESGTGYDEIAGDLIRHKSSAEVSEKSQVALKLEKRKLHSEVRKAQKRTGLLESRTIKVVVPQGSILAPILFSPYAPDLVEYIGGNHCTLYADDTSVLILKAYQQQTIAEANKTLDVLYSWFC

Sequence clustering based on sequence similarity using MMseqs2