Basic Information

Insect: Phortica okadai
Gene Symbol: MBD-R2
Assembly: GCA_034638295.1
Location: CM067849.1:44740484-44744442[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.4e-21 1.4e-17 63.4 0.0 4 76 456 526 453 527 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.4e-21	1.4e-17	63.4	0.0	4	76	456	526	453	527	0.93

Sequence Information

Coding Sequence: ATGGGTCGCCGTTGCTGTATTGCCGGTTGTCAATCAACTTCTCGTTTGCCGGAGCATCACGGCGTCACGTATCATTCCTTTCCGCTTGATGCTGCCATACGTGCAGTTTGGATAAAAAACACACGCCTCAGCCCGGAGCGACATATTACCAAAAGCGTTTTGGTTTGCTCCCGTCACTTTCGTCGCAATGATTTCCAACCCATTCGCAATGGAAAATATCTGCTAAAAGCACGCGTGTTTCCCACTGTCTTTCCATGGGGTAAATTGGATCAATCGCAAGTGGAAGCCGATCAAGAGGCGTTGAAAAATGCCAACGTTGATGTATATTCAGCAGTAGCAGTTAATACAAACAGCACAGAGGATGTTACCAAGGCAACCGTAGCCGCAACAGTGGCACAAATACTTGCTGAGACGGCGGAACTAAACGCAGCGGCAGCGGTCGGCAGTAAAACGGCAACAGCGACTGCGACCAAAGCAACATCCTCGGCTAAGTCAGCGGTCACGCCAGCAGCAGTCACGTCCAGCAAAACAGAATCGCCCAGTGTGAAACCCTCAACGCCCGATTTGGACAATACGCCTACAGCAGGTGGAAAATACGAGCCAGCAACGTATTTCGGTGTGGGTGCACGTTTCCAGGCCAAGCGAAGCGATGGCTTGTGGTACGTTGCGCGTGTCTTAGAAGTGGGCGGCAATGGCGAAGAAGTGTTAGTGCGCTATGAGCGCAACAGCAAGAATAAAATGACGTATGATTTGAAACCTGAATggataaataagaaaaattgccGACAGCGTGTAAATCCACGAGGCCTGCCGGTGTTTGCATTGGAAGAGCGCTGTTTAGCACGTTGGTCAGGACCACATAAATTCCCAGGCACCGTCAAAAAAATACTTGAGAATGATACCTATGAGGTGCTATTCGACGATGGATACACAAAGAATGTACGGGCATTACATATGAAGAAGTTACCAGCCGAGACATTAGGATCCGCTTACAGTAGTGTAGATTCGACTAATGTGACTAACATCTCTGCGGCAAGCACAATGGAGCTCAATGCGGATGCGCAAGGTGCTGATGTATCAACTGATGCTAGTATAATGTCAACAACGGCGTTAGGTTCGGACGCAGCAACACCTGCAATCAAGTCTGCCAAGTCTTCAAACGCTGCCgctagcagcaacaacaagaaacgcAGTGCGGTTGCACAGCGCAAGGATTGGCCACTGTTGGATATGTCCAAATTGGATACGGCGGATCTGAACTTGCCAGAAATACCACGCGATGGCGAGTGGACTTGCCACTGGGTTAATGATCAACCCATTGGTACTGAAGGTTTTCTTATTGTTGGTGAACATCGTAAACCAACGGTCATTGTTGAGGATTGGCGTTTACCCGCCGGCTGGGTGAAGCACATGTATCAACGTTCGAATGTGCTTGGTAAATGGGATGTCATACTAGTCTCGCCTGGCGGCAAACGTTTTCGCTCCAAGTCGGACCTAAAAGTATACCTTGAAGATCAAGGCTTAGTGTACAATCCCGATATTTATGACTTCAGCATTCATCGACGTCGTGCTAAGGATATCAATGCCTACGTCTATACATCTGATTATAAGCCACAAGCGCCGATGAAACCCAAGGGCTTGGATATTTCAGATCTTGACACAACGTTGGATGAACCAACAAGTTTACCACTGAGCGTGACATCAACACCTCTACCAGCAAGTAGCGGCGGTGAGTATTTGGAAGCACCCGTGGCACCTCTAGTGCCACCAATGGAACTAATGTCACCGCAGGCGGCAGCTAAATCGGATACGACAGGTATGCTGTCGGAATCAAATTTGGATAGTTCGCCGACTGTTAGCACTAGGAGCGGTTTGAAACTTGAGGATGGCTATGCCTTAATTGGAGGACTCAAAGTGCAGATGATAGACAATCTGTTTCGCTGTCCACATGAAGGTTGCTCAAAGAATTTTCGTAAGGAGGATCATGTTCTCATACACGTTAAGCATTATCACAAGGATATGGCCAAATTGATCAGCGATTGTCCAAAGATGCAAGAATTAGCGGTCAAGCGTACTCATCCTACTTCAGTTGAGCACAATGATTCACATCCTAGGAACCAAATACCAAACCAACAATTCTTCGCAAAATTGCACCAGCAGGACTTGCAGCAATCACGTTCATTTCGGCGCGGAGGTGTTGGCAGTAGCAGTGGAACGGCTACTACACCTGCCTCAGCTGGTCTATCAACGCCGGCAACCCCAACCACTCCTGCGACACCGACTGCTGTATCCCAGCTTGTTTCCCCAACAGTTGCCGGGAAGGAAAGTTCAGACGGATTGTCGGTGGGAAATGCAAATCTTGATACATCAAAGACAAGTGCTAATACCGTTGATCCAGACAATAATATTTCAAGCCCAACTGTGACCGGCAGTTTGGCTTCACCTGCTGTCGCTGATTCGCTTTCAGCTGCGTCACCTAGTTCAAAACGTGCACGTTTCTCGCCCACCAAACGTGCGATTGGCTCTCGCAAGAGTAATCGACAGCGTACAACGCGACGTTACCTAACAGCTGCACAGGCCACCGCGGCACCAAGCGCTTTGCCGTTGGCGCATATACCGGGGGCATCTGGTGACGCCAGCATTGCCAATTCCGATTTCGAGGAATCAAGTCGTCAGTCATATAACAATACGCCCGATGCACGGCCTAGTGAACCAAAGAAACGTCGTGTGGCTGCCAGTGCTACACCTGTTAGTTCTGCGTATTCCCCCGCCACGGGGGATTCCATTTCGACCCCTACTTCCAATGAAGTGGAACTTGAATCAGTGGGCAGTGTGCCACAAGCCCCGGCGCCACAATACATCAAAGAAAATGgagaattaataaaaattgtgcGCATGCGTCAGGAAGAGATTATAAATTGCATTTGCGGCTATGGCGAGGAAGATGGCCTGATGATACAATGTGAGTTGTGCCTCTGCTGGCAGCATGGCGCCTGCAATGGAATTGTCAAGGAATCAGATGTGCCGGACAAGTACGTTTGCTATATATGCCGTAATCCTCAACGGGTACGTGACTCAATGCGCTACAAACACGATCAGGATTGGCTATATGAGGGTAAACTGCCCGTAGCCAATTATCATTTAAGCAATCCCAATTCTGCCAAACTATTCGAGTTTCTTAAGAAATCGCATACGATCACGGGCAACTTGATTGAGATGAAGCGTTTTATGCACTCGCTGCGcgtaaaaatcaacattgcaAATAATCGCCTGCATCCGAAATTGTACCTCTGGGCCAAAAAATGGGATGATGACGAGGAGGCACAGGATGTTAAGCTCAATACGCCATCGAAGCGAATAAAAGTTGGCGGTGCAGCATCTACGCCGGGTTCAGAGCAACCACCCATGCCACACATACCGCAACCGGAGGCTGCCATCGATCCCGAGGAATGTCAGGTGCGCCTGATTGAGCACGTGAAGGTGCAGCAGGACTTGGTTATGCAACGTTTGGACGATATTGAGTCTGAAGTTGATGCTTTGGAAAAAGttgatgatttcgaagatatgaAGGATGCTGATATCTCTCAGACAAAGGAAGCTTTGGCAGTTTATATAAAAGAGCTGGAGACCCTAAAGCAGATTGCCAAGATCAACGCGATTGTCAACACGAAAGAGTCACTGAATGAGTCTCAGAATACCAGCGTTGTAACCTAG
Protein Sequence: MGRRCCIAGCQSTSRLPEHHGVTYHSFPLDAAIRAVWIKNTRLSPERHITKSVLVCSRHFRRNDFQPIRNGKYLLKARVFPTVFPWGKLDQSQVEADQEALKNANVDVYSAVAVNTNSTEDVTKATVAATVAQILAETAELNAAAAVGSKTATATATKATSSAKSAVTPAAVTSSKTESPSVKPSTPDLDNTPTAGGKYEPATYFGVGARFQAKRSDGLWYVARVLEVGGNGEEVLVRYERNSKNKMTYDLKPEWINKKNCRQRVNPRGLPVFALEERCLARWSGPHKFPGTVKKILENDTYEVLFDDGYTKNVRALHMKKLPAETLGSAYSSVDSTNVTNISAASTMELNADAQGADVSTDASIMSTTALGSDAATPAIKSAKSSNAAASSNNKKRSAVAQRKDWPLLDMSKLDTADLNLPEIPRDGEWTCHWVNDQPIGTEGFLIVGEHRKPTVIVEDWRLPAGWVKHMYQRSNVLGKWDVILVSPGGKRFRSKSDLKVYLEDQGLVYNPDIYDFSIHRRRAKDINAYVYTSDYKPQAPMKPKGLDISDLDTTLDEPTSLPLSVTSTPLPASSGGEYLEAPVAPLVPPMELMSPQAAAKSDTTGMLSESNLDSSPTVSTRSGLKLEDGYALIGGLKVQMIDNLFRCPHEGCSKNFRKEDHVLIHVKHYHKDMAKLISDCPKMQELAVKRTHPTSVEHNDSHPRNQIPNQQFFAKLHQQDLQQSRSFRRGGVGSSSGTATTPASAGLSTPATPTTPATPTAVSQLVSPTVAGKESSDGLSVGNANLDTSKTSANTVDPDNNISSPTVTGSLASPAVADSLSAASPSSKRARFSPTKRAIGSRKSNRQRTTRRYLTAAQATAAPSALPLAHIPGASGDASIANSDFEESSRQSYNNTPDARPSEPKKRRVAASATPVSSAYSPATGDSISTPTSNEVELESVGSVPQAPAPQYIKENGELIKIVRMRQEEIINCICGYGEEDGLMIQCELCLCWQHGACNGIVKESDVPDKYVCYICRNPQRVRDSMRYKHDQDWLYEGKLPVANYHLSNPNSAKLFEFLKKSHTITGNLIEMKRFMHSLRVKINIANNRLHPKLYLWAKKWDDDEEAQDVKLNTPSKRIKVGGAASTPGSEQPPMPHIPQPEAAIDPEECQVRLIEHVKVQQDLVMQRLDDIESEVDALEKVDDFEDMKDADISQTKEALAVYIKELETLKQIAKINAIVNTKESLNESQNTSVVT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01195308;
90% Identity: iTF_01195308;
80% Identity: iTF_01195308;