Basic Information

Gene Symbol
MBD2
Assembly
GCA_034638295.1
Location
CM067849.1:40497933-40499249[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 7.2e-25 2.4e-21 75.5 0.0 1 75 9 78 9 80 0.95
2 2 9.5e-06 0.031 14.2 0.0 27 76 152 210 128 211 0.91

Sequence Information

Coding Sequence
atgcAACTGAACCCAAGCGTGACTATAGAACGCAAGCGAGTCGATTGCAGCGCGCTTCCGAAAGGCTGGCAACGAGAAGAGGTGTTGCGCAAATCTGGAATCGCAGCAGGAAAAGTggatatttattattatagTCCAACAGgcaaaaaaatagatagtaAGCCTCAATTGGCACGACAGCTAGGTGACACATTTGATATAAGCAGTTTTGATTTTCAAAGCGGCAAAATGATACAACATCAGCTGCCACCACCTTCCATTTCACTTTATCGCTGTAATCCTACAATGTCTGCAACGACGAGTGGTTCCGCAATGGCCAACAGTGCGAATGTGCTTAAACGAAAGTACAAATCTCAACAGTCTGGGGTCAGCAATAATATCGTTTCAAACTCACCGACATGCAGCGGCACCACCACCACCGTAGCTAATCTGCGACATCAACTTGAATTCAGCCGCGCATTACGTACCGATGTATCGTTAGTACCTCCAATACGGCAGACCGCATCTATATTCAAACAACCAGTGACAGTAGTACGCAATCACGACAACACTAAAGTTCAACATAATACCAAGAACGGTGCTCAGGAGAAGCCAAAACAACTTTTCTGGGAGAAACGCTTAGAACGTTTGCGTGCTTGTCATGATTCTGGCGAAGAATTCGATGATATTTCTTTGCCAAAAAATATACGCACAGTGGGTCCAAATGTCAACGAACAAACAGTACTACAGTCTCTTGCAACAGCACTGCATGTTCTCAATACCGGTGTACATGGCCAATCATCGACAAAGGCGGAACTTACAAAAAATGCAATGGCATATTTAAATCCCGAGCAACCACTAATGCATACAgtaatgatatcagaagacgACATACGTAAACAAGAAGATCGTGTTAATGTTGCTCGGCGAAAACTTCAAGATGCACTCAAGGTGTAG
Protein Sequence
MQLNPSVTIERKRVDCSALPKGWQREEVLRKSGIAAGKVDIYYYSPTGKKIDSKPQLARQLGDTFDISSFDFQSGKMIQHQLPPPSISLYRCNPTMSATTSGSAMANSANVLKRKYKSQQSGVSNNIVSNSPTCSGTTTTVANLRHQLEFSRALRTDVSLVPPIRQTASIFKQPVTVVRNHDNTKVQHNTKNGAQEKPKQLFWEKRLERLRACHDSGEEFDDISLPKNIRTVGPNVNEQTVLQSLATALHVLNTGVHGQSSTKAELTKNAMAYLNPEQPLMHTVMISEDDIRKQEDRVNVARRKLQDALKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_01195989;
80% Identity
iTF_01195989;