Basic Information

Gene Symbol
E2f1
Assembly
GCA_034638295.1
Location
CM067849.1:49186872-49193337[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 9e-31 6.9e-27 93.3 0.1 2 65 373 436 372 436 0.98

Sequence Information

Coding Sequence
ATGTCTAAATATTTTAGTACATCAACGCCAACACCAGTAACAACATCGTTAATAATCGGCGCTAACAATCACAATAACAGTAACAATAACGGCTACAACAATATAacacaacatcagcagcatcaacatcagcaacaacaaaaacattatgtTATGCGCAAATTTTCACATCTTAATAATCTTAGCGAAAATTGTGGTAGCGGCGGTGATGTTGGTAACaaccaaaacaataacaacaatgtcaTGATGAAAAATGAAAGCTTATATAATGATAACGCAATCATGATCAAATCGGAAAAATTACTTGATGGTGATGATAGTAATGGCGCCGGTGCTGTTTATATGGCAACACATCTGCTTGATCATGGTTATGGTGTTagttgtacaacaacaactccagGAGGAGTAGGAGCAACAACACCGGCAGGTAtaacaacaccagcaacagcGACGCCACGCATAATTTTGACAGCATCATCTAAAACGCAGACAAATGAATTGACGCATTACTATAagCAAGTGAAACGCCGCCTACCTATGACCGAAACGCATCCGAAGAAACAAGCAAAACAGAGTGCGCAACATCAAACTctataccaacaacaacagcagcaacatgtgacacaacaacacaacattaGCAGCAGCAGTGAAAATGGTTTCGCAACGCCTACGCCTTCACCACAAATGCTaatacagcagcagcagcaacaacaacaacaacatcaacatcaacagctgcatcatcatcatcagcagccaCAACGTCCGCCATCGGTCGCTTCGACTACATCGAATAGTAGCTGTAGTCTTGGCAGTAGCAGTCTTAACAGTTATGCTGCATCAGTCGCAACGCCAACATCATCGACGACAACAACTGGTGGCGGTCGATCTTCATCGTCGGGCTATAAATCACATACGCccacatcatcgtcatcatcaacaagcAACAATATATTGGGaaatgttgttgccgctgGGCGGCactcaacgacgacgacagcaacagcaacaacaacaccaacactacaaccatcatcaacaacacaacaaaccACATCCGCCTCTTCCTCTACATCATCGTCAAAACGTACACCGGCCGAAGGCACACGTGCAGATACCTCATTGGgtatattaacaaaaaaatttgttgatttaCTCCAAGATTCACAGGATGGCGTTGTTGATCTCAATGATGCATCACATCGTTTATCGGTGCAAAAACGTCGCATCTATGATATCACAAATGTTCTGGAAGGAATTGGCATATTGGAGAAGAAAtccaaaaataatatacaatGGAAAGGTGGCAATTCAATGgcaacagcatcatcatcgacGGTGGGCGGTGGTCTCGATCGACCAAGCGATGTAACAATGGAGAATAAAAGACTCACAGAAAAGGAGAATCAATTGGATGAAGAGATCGATAAAATGCGCAATGAGTTGAATCATTGCTTTACACACAATGCCAAATTCGCCTATGTGACCCAAAGTGATTTACTTAAATTGGATTTGTTTAGGGATCAGATTGTAATTGCCATTAAGGCGCCACCAGAAGCGAAACTTGTGTTACCTGATACTCCTGTGCCACGTGAGATTTACGTAAAGTCGGAAAATAGCGGCGAAATAAACGTGTTCCTCTGTCACGATAGCTCACCAGTGACTTCGCCAAATTCAAATGGCAGCGTTTATGGCAGCAGCGCAATGGCGTCCAAGACGCGTCTGCCCCCGCAATATCAAAGGCTTAACGATCCGCTCTTCAATGACATAAATCGCTTATCGCCAATGATTGGTGCGGTAATGAATCAAAATCATCATCGAATTGgcgGCTTTGGCACGACCGGCACCCGTTCAGCATCGCGCAATCTAAGCAAATCGCTTGAAGCTGCAGCTGCGGCCGCTGCGAATGGTTCGATAGCAAGTGATTATAGTTGTGATATTGTAGAAAGCTTTCAGgcgcatcagcagcaacaacaacagcaatattgTAATGCTGCCGTTGATTATGTTGTTGATAATGAGGACGATGCTGGTTTCGATATGATACCAAGCATAACACATCCAGTAATGCGTATCATGGGtgccaacaataataataacaataacaaacaacttGATAGCAATAGTAAcactaataacaacaatgctaCTACAGAAGcattaaaattacaaaatgttgCTGATCAAGCGCTCGTCAATGTCGACAAGATATTAGCAACAAGTGCTGGTTTCTCAGCAAACTCAACATCGTCGTCGCCGCCATCGCcgcaatcaacaacaacagtagtaGGAACCGTTGTCGGTTCAGCAGTGATAACGCCAACGCGTACAACGCGAGCagctgctgcggctgcggcTGCTGCAGCAGCACTTGCTGCATTGCAACATGAAGAGTTGCAACcgatgcaacagcaacaaatcatgaataaaaaaaatacgctTAATAGTTGTAATCCAGATAATAAGTCAACGTcgttgtcaacaacaacattagtaGTAGGAGTAGGAGGTGCAGAAGTTAAAGAAGatgcaactacaacaattctTAGAAAAGATGTTACAATGTTTAATTGTGCAATGGATGGACACAAAGTGTCTTTgattaacaacagcaacaacaatccaAATAATGTTTGCGACAATGGCAGTAACGGCGGCAAGCacaacaacgataacgacaatgttgctgctgctgccggcgGAGATGTCGTAGTTGTCGATGACAACGGGGTCATCATTGCCGATCATCAGACAAATTCAACCTGCGAAATTATAAGCAATGCTGCAATTGCCGCCGATAACAGTTGTCATAGCAATTGCAGTAATAGCACTTTGCCACAATTGGACACATTTTTGGGTCAGATCGATCCGCGCATGTCGCACCcATTCTTGGACATGTCGAGCTTTTTGTCTATTGAGCCGCCGTCCGAAGCCGAATATAATTTTGCGCTGAATGAGTCTGAGGGCATTGCGGAATTGTTTAGTGTTTATGCTCCATACGAGGACACATATCCTTAA
Protein Sequence
MSKYFSTSTPTPVTTSLIIGANNHNNSNNNGYNNITQHQQHQHQQQQKHYVMRKFSHLNNLSENCGSGGDVGNNQNNNNNVMMKNESLYNDNAIMIKSEKLLDGDDSNGAGAVYMATHLLDHGYGVSCTTTTPGGVGATTPAGITTPATATPRIILTASSKTQTNELTHYYKQVKRRLPMTETHPKKQAKQSAQHQTLYQQQQQQHVTQQHNISSSSENGFATPTPSPQMLIQQQQQQQQQHQHQQLHHHHQQPQRPPSVASTTSNSSCSLGSSSLNSYAASVATPTSSTTTTGGGRSSSSGYKSHTPTSSSSSTSNNILGNVVAAGRHSTTTTATATTTPTLQPSSTTQQTTSASSSTSSSKRTPAEGTRADTSLGILTKKFVDLLQDSQDGVVDLNDASHRLSVQKRRIYDITNVLEGIGILEKKSKNNIQWKGGNSMATASSSTVGGGLDRPSDVTMENKRLTEKENQLDEEIDKMRNELNHCFTHNAKFAYVTQSDLLKLDLFRDQIVIAIKAPPEAKLVLPDTPVPREIYVKSENSGEINVFLCHDSSPVTSPNSNGSVYGSSAMASKTRLPPQYQRLNDPLFNDINRLSPMIGAVMNQNHHRIGGFGTTGTRSASRNLSKSLEAAAAAAANGSIASDYSCDIVESFQAHQQQQQQQYCNAAVDYVVDNEDDAGFDMIPSITHPVMRIMGANNNNNNNKQLDSNSNTNNNNATTEALKLQNVADQALVNVDKILATSAGFSANSTSSSPPSPQSTTTVVGTVVGSAVITPTRTTRAAAAAAAAAAALAALQHEELQPMQQQQIMNKKNTLNSCNPDNKSTSLSTTTLVVGVGGAEVKEDATTTILRKDVTMFNCAMDGHKVSLINNSNNNPNNVCDNGSNGGKHNNDNDNVAAAAGGDVVVVDDNGVIIADHQTNSTCEIISNAAIAADNSCHSNCSNSTLPQLDTFLGQIDPRMSHPFLDMSSFLSIEPPSEAEYNFALNESEGIAELFSVYAPYEDTYP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01195803;
90% Identity
iTF_01195803;
80% Identity
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