Basic Information

Insect: Phlebotomus argentipes
Gene Symbol: MBD-R2
Assembly: GCA_947086385.1
Location: CAMTYR010000005.1:2404021-2407387[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 6.9e-18 1.7e-14 52.6 0.1 4 70 377 440 374 447 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	6.9e-18	1.7e-14	52.6	0.1	4	70	377	440	374	447	0.90

Sequence Information

Coding Sequence: ATGGGAGGCCGAAAATGTGTGGTTTCCGGCTGTCCATCGCACTCGGCGAGGAAGGAGGATCGCGGAGTGACATTTCACAAGTTTCCTCACAATCCCAAGACACGCATTCAGTGGCTGAACATGTGCAAAATGGATCCGACACTGTTGCCCCCGAAGAGCATGAATGTGTGTTCTCGCCACTTTCGTCAAGTGGACTTTCAGACATTTAAGGGCACCAAATGCCTCCTGAAAATTGGAACCTATCCGACAATCTTTCCCTGGGGCGTGACGCCAGATCTACCGACAGAGGGCGATCAGAAGAAGCTAAACGCTAAAGAGACAGGGACTTCGAAGGCTCCTGTTGAGAAGGGAGAGGATAGTCTTAAGCCTCCTCTCACCGCTGAGCAGCTTAAGCTGAAGAAGAGCAGTGCAGTGAAGAGATCAGCCAGTTTGGAGAATGTGAATAAGCAGCCACAGAAGAAAATCCTTAGAAAGGCATCAGACTCGAGTATTGCCAAAGAGGAGAAAATCGCGTCGCCGACAAAGAAGTTTGACCCGGTGACTTGCTTCACGCCGGGGACGCGCATCGAGGCGCAGGATTTCAATAACGTGTGGCATTCGGCAATGGTCATGGAGGTGGATAATGCCGACCGAGAAGTGCTCGTTCATCTGGAGATCAAGGATCCGGAGAAGTCCACTGGGATTGTCGACGAGTGGATTCCAATGGATAGCAGTCGCTTGAGACCAATGCAGGTGAAGAGTGAGGTTGACAAGCAGAAACCTCTGGTGACATACACAATTGGTGAGAAGATTCACGCTCGTTGGAATGATGCTCGCAAGTTTAGGGCTACGGTTACGCAAGTTCTGGAGAACAACACTTACGAAATACTGTTTGACGACGGCATTTCGAAGGTGGTGACCACAAAGGAGATGTGGAAGATTCGTCCCAGTGTGAACAATTTATTTGGCAAAGCCCGTCCTCGTCCGAAGAAACGTCCAAAGCTGGGAAAAATGCGCATTCCGTCGCGATACTACAGAAAGAAGGCGAGCTCTGTAAATGAAAACGAATGGTATTGTCAATGGATTGACGATCGACCCGTGGGCAGAGAGGGATTCATCGAGTGTGCGTCGGAGACTAAGAAGAGTTCAACGATTGTGGACGATCCGAGACTCCCTGAAGGCTGGGAGAAGCACATCGTTGCTCGCTTCTCTGGCGTGACGAAGTGGGACGTGATACTCGTGCACCCGAACGGGAAGAAGTTCCGCAACAAGCAGGAACTAAAGATCTATCTTGAAGAGACGAATGAGTATCAGTATGATCCGAATGTGTTTGACTTTGGTATCCACAAGAAGCGCGCTCGGTTGATGAAAGTATACACGTACACAGAAGAGTACAAGGCGAAATTTGCTGAGATGGCAAAAGCTCAACAATTGGCCGCTCTGGAGGCGAAATCCTTGGGGAAGGTGGATGCAACAGTTGCTGCTGTTGTGGGGGAGCAAATTATCGGCGAGGGATTTGTCTTGGTGGATGGTCTGAAGGTGCAGATAATTGAGAATTTGTTCAGATGTCCCAAGGAGGGGTGCTTCAAAAACTTTAGGAAGGAGAATCTCTTAAAGATACACATCAAGCACTATCACGAGGAGATTGCGAGGCAGCTTACAGCTCCGCCCACAATGACTGACCTCGCGTACCAGAGAACAGTTTGTCAGGCCATTGAAGAGATCATCCCAGAAAAGTCTCCGAGGGTGCAGCAGTTGGAGAAGAGTACACAAGACACTTCCCCGCCAAGGCTGCAGAGGAAATCCAACACTGGGTCGAGTGGCGGGAAAGTTGGTGAGGTCAGGGTGAAACTGGAGGGCGGATATTTCAGACAAGGGAGTGATATGCAAGCGGACATCGTGAAGATCGAGCCAGAAAGTGTGCTGTCGAAGGAGATGCTGGCTGAAGAGCCTCGTCGGAAGTACAGTCTTCTGGAGGAGGCACTCAATTCCAAGGGCCCGTTGGATATAGGGAGGGACAGCAAAGGGCTGAAGTCACCTCTGTCTGAGCATTCCCAGGATGTAGAGTACACTGTGGACCCAGAGATGCACATCAAGACTCATGCGGTGAGTCGACCCCAACTCCTGAAGCGCAAGAAGAGCCATACTAAGTTCCGAGGAGTTTCCTCTTCAACGGGATATCGACGAAACTACGTGAAGAGGCGATTGATGCTGAAGAACCGCATGGTTCTCGAAGCTATGGGGGATTCTGAGGAGACTCGACACTCTTTCAGTGCTGACAATTTGTCGCATCGACCATCACTGAGGAGGGCCTTCGATGATGCTCATGAGACAACAAATAGTCAAACGACAACCACGGAGCACAGTCAAAGTCCGCAGTATATCAACGAGGGTGGGGAATTGATAAAGATTGTGCGGATGCGCCAGGAGGAGATAATCAACTGTCTGTGCTCCTTTTCGGAGGAGGACGGCCTCATGATCCAGTGTGAGCTGTGTCTGTGCTGGCAGCACGGCATCTGTAATGGAATTGAGAAGGAGAGTCAAGTGCCGGAGAAGTACATTTGCTACATCTGTCGCAATCCAGCTCGTGGCCGCGAGTCTATGAAGTATATTCACGATCAGGATTGGCTGTATGATGGAAAACTATCCACGACGCAGTATCACGCGCAAAATCCAAGTCTCTCGGATCGCTTTGACACATTGAAGTCCAGTCACACGCTCACGGGTAATTTGCTGGAGTTGAAGCGCTTCATGCACAGTCTGAAGCTGAAGATCAACATTGCTGAGAACAAGGATCATCCGAAGATGTATCTGTGGTCGAAGAAGTGGGAATCGAGTCCGCCGCCAGCGGAGTCCGGCAGTCAGGTGGAGGGTGTGAAGCTGGAGGAAGGGAAGAAGGTGAAGCCAGAAGGAGGCACTGGCGTGTCGCCGCAGAAGGTGAACAATGTGCAGCAACCCAAGATTCCAGAGCCTGAGGCGGCCATTGACCCGAAAGAGTGCCAACTGCGTCTTCTAGACCACATTCAGAAGATGCAAAGTCTGGCCATGATGCGACTGCAGACCATAGACGAGGAGATAATGGCTTTGGAGGAGGCTGACAAGGGCTTTGCACAAATGGAACCTGTGGACAATTGCCCAAAGACGAAGCAGACAATGCGAATGCTTCTCGCAGACCTCCAGACACTCCACAAAATCGCCAAGATTCAAGGGTAA
Protein Sequence: MGGRKCVVSGCPSHSARKEDRGVTFHKFPHNPKTRIQWLNMCKMDPTLLPPKSMNVCSRHFRQVDFQTFKGTKCLLKIGTYPTIFPWGVTPDLPTEGDQKKLNAKETGTSKAPVEKGEDSLKPPLTAEQLKLKKSSAVKRSASLENVNKQPQKKILRKASDSSIAKEEKIASPTKKFDPVTCFTPGTRIEAQDFNNVWHSAMVMEVDNADREVLVHLEIKDPEKSTGIVDEWIPMDSSRLRPMQVKSEVDKQKPLVTYTIGEKIHARWNDARKFRATVTQVLENNTYEILFDDGISKVVTTKEMWKIRPSVNNLFGKARPRPKKRPKLGKMRIPSRYYRKKASSVNENEWYCQWIDDRPVGREGFIECASETKKSSTIVDDPRLPEGWEKHIVARFSGVTKWDVILVHPNGKKFRNKQELKIYLEETNEYQYDPNVFDFGIHKKRARLMKVYTYTEEYKAKFAEMAKAQQLAALEAKSLGKVDATVAAVVGEQIIGEGFVLVDGLKVQIIENLFRCPKEGCFKNFRKENLLKIHIKHYHEEIARQLTAPPTMTDLAYQRTVCQAIEEIIPEKSPRVQQLEKSTQDTSPPRLQRKSNTGSSGGKVGEVRVKLEGGYFRQGSDMQADIVKIEPESVLSKEMLAEEPRRKYSLLEEALNSKGPLDIGRDSKGLKSPLSEHSQDVEYTVDPEMHIKTHAVSRPQLLKRKKSHTKFRGVSSSTGYRRNYVKRRLMLKNRMVLEAMGDSEETRHSFSADNLSHRPSLRRAFDDAHETTNSQTTTTEHSQSPQYINEGGELIKIVRMRQEEIINCLCSFSEEDGLMIQCELCLCWQHGICNGIEKESQVPEKYICYICRNPARGRESMKYIHDQDWLYDGKLSTTQYHAQNPSLSDRFDTLKSSHTLTGNLLELKRFMHSLKLKINIAENKDHPKMYLWSKKWESSPPPAESGSQVEGVKLEEGKKVKPEGGTGVSPQKVNNVQQPKIPEPEAAIDPKECQLRLLDHIQKMQSLAMMRLQTIDEEIMALEEADKGFAQMEPVDNCPKTKQTMRMLLADLQTLHKIAKIQG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01191238;
90% Identity: iTF_01191238;
80% Identity: iTF_01191238;