Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.2e-34 1.7e-30 107.4 0.0 1 86 57 141 57 143 0.97

2 2 4.2 1.7e+04 -1.6 0.5 9 40 229 259 224 264 0.65

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.2e-34	1.7e-30	107.4	0.0	1	86	57	141	57	143	0.97
2	2	4.2	1.7e+04	-1.6	0.5	9	40	229	259	224	264	0.65

Coding Sequence: ATGCCTCCGATATTTGAATCGAACTTCTCTATTCGCAAAATTCTAGCTGCCAACGAGCATTCTCATCCTATCATAAAGGTTGAGCAAAACCTACCACCGACACCGCCACGATCTGAAGGCACATCCTCCCCAGAAAACGCTGCGTCGCCAAACATCGAATCGGCAGAGCAAAGACCCGGCTTCACCTTTGCCGCCATGGTGGCCATGGCAATACGCAGTAGTCCGGAGAAGCGCTTGCCCTTGAGTGCAATACAAGATTGGATCTCGGAACACTTTCCTTACTATCGCAAGGATCAACATGGCTGGCAGAGTCAAGTGCGTCACACTTTGAGCACCAATTCGTGCTTCGTAAAGGTGCCGCGTCCTCTAGATGATCCTGGCCGTGGAAATTATTGGGCGCTAAATCCAGCAGTTGAAGATATGAAAGTAAATGCATCGAGTGGTCGTTTGCAAATCGATCCAAGCAGCGCTGCGGCACGCTCTCATTTTGCTATTCATAATAGTGCCTATGGCGGACATCCCTTGAATCAAGTTATTACCCACGGCGTGCCAATGGTTCATCCTCAAGCCCCTACCGCAGTTTACTTTCCCACGCCGGAGGAACTTGGCCGGGCACAACAGGTCATGATGATGCAGTCTCTGCAGGAGCAACACGGAAGATATGTCTTTcatcaacaacaaaagcaattgATACAACAACAATTATTGCAaatgcagcagcaacaacaatttcaacaaaaatatgaacaaCTGCGACAACAAATGCTATTCCATCAACAACAATGCGAATATATGATGGCCAAATAA
Protein Sequence: MPPIFESNFSIRKILAANEHSHPIIKVEQNLPPTPPRSEGTSSPENAASPNIESAEQRPGFTFAAMVAMAIRSSPEKRLPLSAIQDWISEHFPYYRKDQHGWQSQVRHTLSTNSCFVKVPRPLDDPGRGNYWALNPAVEDMKVNASSGRLQIDPSSAAARSHFAIHNSAYGGHPLNQVITHGVPMVHPQAPTAVYFPTPEELGRAQQVMMMQSLQEQHGRYVFHQQQKQLIQQQLLQMQQQQQFQQKYEQLRQQMLFHQQQCEYMMAK

Sequence clustering based on sequence similarity using MMseqs2