Basic Information

Insect: Philonthus spinipes
Gene Symbol: topi
Assembly: GCA_963082785.1
Location: OY720316.1:10812456-10832327[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.00056 0.089 14.6 2.4 2 21 138 157 137 158 0.94

2 13 2.1e-06 0.00033 22.2 1.3 1 23 183 205 183 205 0.97

3 13 0.022 3.5 9.6 0.9 3 23 213 233 212 233 0.95

4 13 2.1e-06 0.00033 22.2 0.6 2 23 311 332 310 332 0.97

5 13 1.2 1.9e+02 4.1 0.1 1 21 338 358 338 359 0.89

6 13 0.25 40 6.2 3.4 2 22 375 395 374 398 0.87

7 13 5.9e-05 0.0093 17.7 0.2 1 23 510 533 510 533 0.97

8 13 0.0027 0.43 12.4 0.4 1 23 537 559 537 559 0.97

9 13 1.1e-05 0.0018 19.9 5.4 1 23 565 587 565 587 0.98

10 13 0.022 3.5 9.5 0.2 1 23 593 618 593 618 0.96

11 13 0.55 86 5.2 3.2 1 23 624 646 624 646 0.86

12 13 1.4e-06 0.00022 22.8 0.5 1 23 652 674 652 674 0.98

13 13 8.8e-06 0.0014 20.3 2.4 1 23 680 703 680 703 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.00056	0.089	14.6	2.4	2	21	138	157	137	158	0.94
2	13	2.1e-06	0.00033	22.2	1.3	1	23	183	205	183	205	0.97
3	13	0.022	3.5	9.6	0.9	3	23	213	233	212	233	0.95
4	13	2.1e-06	0.00033	22.2	0.6	2	23	311	332	310	332	0.97
5	13	1.2	1.9e+02	4.1	0.1	1	21	338	358	338	359	0.89
6	13	0.25	40	6.2	3.4	2	22	375	395	374	398	0.87
7	13	5.9e-05	0.0093	17.7	0.2	1	23	510	533	510	533	0.97
8	13	0.0027	0.43	12.4	0.4	1	23	537	559	537	559	0.97
9	13	1.1e-05	0.0018	19.9	5.4	1	23	565	587	565	587	0.98
10	13	0.022	3.5	9.5	0.2	1	23	593	618	593	618	0.96
11	13	0.55	86	5.2	3.2	1	23	624	646	624	646	0.86
12	13	1.4e-06	0.00022	22.8	0.5	1	23	652	674	652	674	0.98
13	13	8.8e-06	0.0014	20.3	2.4	1	23	680	703	680	703	0.98

Sequence Information

Coding Sequence: ATGAACAGGGACGAAAACACGGCATATCTGAGATTCCACCGGATTTTCCCCGATGGTTCGATACAGTCCGTCCAATTGAAAATCGACTGCAGGACCAACCAGGTGATCGCCAGGATGCCCATAAATTCGGAATTGCCCCCCGGACACGATCAAAATTTCAGTGaggaaaaattcaattttaattacaacagCCTGAAACTGAACGATTCGTCCATAAGGGTGATAAAACTGGGCGGCGTTGAGGATCTGAATCCGTTGAATTACGCCTCGGAGATATCCACCGTTTTAAATGATCCGATTCAAGTGAAAACATCGCCGAGCAGTAGTTTTGTTTCAAACaatcagaataataacaataacaccAACTTACAGAAGAGGGAATCGAAAGTTCCTAATATTCCAACGATGATACGATGTCAGAATTGCGATACGAATTTTCCGACTAAATATCAATTCCAGCGGCATCAGTGCGAGTTTAATGCGGAGAAAGTCGTTTTAAAGCCGAATATTGATGCGAAGGATGTTGATAAAGGGGTGCGTATGAAATTTGATTGTACTACATGCGGAAAACAGTTTGTTAGTAAAAATAATCTTGAACGGCATTTGACTAGCCATGATgaggataatattaatatttgcgagttttgtaataaacaatttgtaaGTGAAAACCGCTTGCGTATTCACAAAGAAAACCATTGCAAGAAAGCGggtgatattttgaaattttaccgCAGCGACGTGACCGTGTGGAAATGCATAAAATGCTACCAAGTATTCTCCTCGGATGTTTACGCTTGCACTCATTCAGATAACTGCACCGAATTTTTAAACCCCGAAGAATTCCAATCCCGTAACATAATGATCAACGAAAACCAGGAAGAAGTAAAATTCGATTACGTGGAAAAAGTTTTAACGGAACTACTCCTCCAATGCGAATACTGCAACAAAACATACGCCGATAAAGACTCATTGCTCTTGCACCAAAACACCCACACGACGGAATCGAATTACCATTGCGTGATCTGCTTAGAGACATTCGAGTCCTACACCCTGGCAGCGAAGCACTGGCTCACGAAATGCGTAAACGAGGCGAATCTATTCTACCTCCCGAAACTAACCTACTGCAGCACCTGCGAACGGACTTTCAAATCCCACGAAGTCCTCTACTCGCACAAAATCAAGAAGAAACACTACAAACCGAAAAAGTACGTGAATTCCGAACCGATCGAAACGGTCGACTTGGCTGATAAGGAGGAGAACAAGGAGACCATCATTAAGTTGATCGAGGATGTTTTGTGTTCGATTAAATTGAATGTGGGTGAGGGTAAGGAGAAGGCTTCTGAGGATGGGGGGGATGTGGTGGTGAAGAGTGAGATGATGAGCGAGAATAGTAGTTTGAGTATTTCGGAGAATGTGCAGGATGGGGAGGGTTCCGGGAAGAAGAAGAGGGGGAGGAAGAGGAAAATCACGGCGCAGAGTAGTAAGGCTAAGCGGTTGGCTAACAGCGTCGATCCGGGGTTTAAGTATCAATGCGAGAGATGCGGTAAGGTTTTCGATAGGGTTTTGGATTTGGAGACGCACAGGGACACGGATCATACTGCCAATTATAAATGCGAGGAATGCGATCAGgtAGTACACAGTTCGAAAGCCCTATTGATCCACAGCAGAGCCCACCAACGACTCAAACCATACGTCTGCGAAATATGCAAAAGATGCTATTCCCAAACGTCCCACTTGTGGCAGCACATGCGGTTCCATCAAGGTATTAAACCCTTTGCGTGCCCGCACGAAGGCTGTGAAGCTAGGTACACGATTCGTCCGGATTTGAAAGATCACATTAGGAAAGTGCACACCAGGGAACGACCTTTCAAGTGCTCCGTTTGCTCAAAATGTTTTTTGACGGGTTCTGTTTATTATCAGCATAGGTTGATACATACGAATGATCGAAGATACGCATGTGATATTTGCAACAAAAGATTCTTCAGAGCTGATGCGTTGAACAACCACAGAAGGATACACACCGACGAAAGGCCGTATCCCTGCAACGTCTGCGGGAGGCATTTTAGGCAGAAAGGAGACAGGAACAAGCACGTACGCACCCAGCATCCAGATGTTCAgatttaa
Protein Sequence: MNRDENTAYLRFHRIFPDGSIQSVQLKIDCRTNQVIARMPINSELPPGHDQNFSEEKFNFNYNSLKLNDSSIRVIKLGGVEDLNPLNYASEISTVLNDPIQVKTSPSSSFVSNNQNNNNNTNLQKRESKVPNIPTMIRCQNCDTNFPTKYQFQRHQCEFNAEKVVLKPNIDAKDVDKGVRMKFDCTTCGKQFVSKNNLERHLTSHDEDNINICEFCNKQFVSENRLRIHKENHCKKAGDILKFYRSDVTVWKCIKCYQVFSSDVYACTHSDNCTEFLNPEEFQSRNIMINENQEEVKFDYVEKVLTELLLQCEYCNKTYADKDSLLLHQNTHTTESNYHCVICLETFESYTLAAKHWLTKCVNEANLFYLPKLTYCSTCERTFKSHEVLYSHKIKKKHYKPKKYVNSEPIETVDLADKEENKETIIKLIEDVLCSIKLNVGEGKEKASEDGGDVVVKSEMMSENSSLSISENVQDGEGSGKKKRGRKRKITAQSSKAKRLANSVDPGFKYQCERCGKVFDRVLDLETHRDTDHTANYKCEECDQVVHSSKALLIHSRAHQRLKPYVCEICKRCYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCSVCSKCFLTGSVYYQHRLIHTNDRRYACDICNKRFFRADALNNHRRIHTDERPYPCNVCGRHFRQKGDRNKHVRTQHPDVQI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01185478;
90% Identity: iTF_01185478;
80% Identity: -