Basic Information

Insect: Philonthus cognatus
Gene Symbol: topi
Assembly: GCA_932526485.1
Location: CAKOBG010000225.1:4-3311[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 0.00083 0.17 14.7 2.4 2 21 138 157 137 158 0.94

2 11 9.7e-07 0.0002 23.9 0.7 1 23 183 205 183 205 0.97

3 11 0.033 6.8 9.6 0.9 3 23 213 233 212 233 0.95

4 11 1.4e-06 0.00028 23.4 0.8 2 23 312 333 311 333 0.97

5 11 0.37 77 6.3 3.4 2 22 376 396 375 399 0.87

6 11 0.00086 0.18 14.6 0.1 1 23 511 534 511 534 0.97

7 11 0.004 0.83 12.5 0.4 1 23 538 560 538 560 0.97

8 11 1.6e-05 0.0034 20.0 5.4 1 23 566 588 566 588 0.98

9 11 0.033 6.9 9.6 0.2 1 23 594 619 594 619 0.96

10 11 0.81 1.7e+02 5.3 3.2 1 23 625 647 625 647 0.86

11 11 0.00014 0.028 17.1 0.2 1 20 653 672 653 673 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	0.00083	0.17	14.7	2.4	2	21	138	157	137	158	0.94
2	11	9.7e-07	0.0002	23.9	0.7	1	23	183	205	183	205	0.97
3	11	0.033	6.8	9.6	0.9	3	23	213	233	212	233	0.95
4	11	1.4e-06	0.00028	23.4	0.8	2	23	312	333	311	333	0.97
5	11	0.37	77	6.3	3.4	2	22	376	396	375	399	0.87
6	11	0.00086	0.18	14.6	0.1	1	23	511	534	511	534	0.97
7	11	0.004	0.83	12.5	0.4	1	23	538	560	538	560	0.97
8	11	1.6e-05	0.0034	20.0	5.4	1	23	566	588	566	588	0.98
9	11	0.033	6.9	9.6	0.2	1	23	594	619	594	619	0.96
10	11	0.81	1.7e+02	5.3	3.2	1	23	625	647	625	647	0.86
11	11	0.00014	0.028	17.1	0.2	1	20	653	672	653	673	0.95

Sequence Information

Coding Sequence: ATGAACAGGGACGAAAACACGGCATATCTGAGATTCCACAGGATATTTCCAGATGGTTCTATACAGTCCGTCCAACTGAAAATCGACTGCAGGACCAACCAAGTCATCGCTCGGATGCCTATAACTTCCGAGTTGCCCCCCGGATACGACCAGAATTTCAGTGAGGAAAAATTCAATTTCAATTACAACAGCTTAAAGTTAAACGACTCCTCGATAAGGGTAATAAAATTAGGCGGTGTTGAGGATTTGAACCCGTTAAATTACGCCTCGGAAATATCCACCGTTCTAAACGATCCTATTCAAGTTAAAACTTCCCCGAGTAGTAGTTTTGTTTCCAACAATCAGAATAACAACAATAACGCCAACTTACAGAAGAGGGAGTCAAAAGTCCCTAACATTCCAACGATGATACGATGTCAGAATTGCGATACTAATTTCCCGACTAAATACCAATTCCAGCGACATCAGTGCGAGTTTAACGCAGAGAAAGTTGTTTTAAAACCGAATATTGATGCCAAGGATATTGATAAAGGGGTGCGGATGAAATTCGATTGCCCCACTTGTGGAAAACAGTTTGTTAGTAAGAATAATCTTGAACGGCACCTGACTAGCCATGACGAGGATAACGTTAACATTTGCGAGTTTTGTAATAAGCAGTTTGTAAGCGAAAACCGCTTGCGGATCCATAAAGAAAACCATTGCAAAAAAGCGGGTGATATTTTGAAATTTTATCGGAGCGATGTGACTGTGTGGAAATGCGTTAAGTGCTATCAAGTGTTTTCCTCTGATGTTTACGCTTGCTCTCATTCTGGGAATTGCACTGAAATTTTAAACCCTGAAGAATTCCAAGCGCTGAGTTTGAATGTTGTTGAAAACCAGGACTCGGAGGTTAAAGTTGATTACGTGGAGAAAGTCTTAACAGAATTGTTGTTACAATGTGAATATTGTAATAAAACCTATTCGGATAAAGAATCGTTGTTGATACATCAAAACACTCATTCAACGGACACTAATTATCATTGCGTGATTTGTATGGAGACTTTCGAATCGTTCACTCTGGCAGCCAAGCATTGGCTTACAAAATGCGTAAATGAGGCTAATCTATTCTATCTTCCTAAATTAACCTATTGCAGCACGTGTGAAAGAACTTTTAAATCCCACGAGGTTTTGTATTCGCATAAAATCAAAAAGAAACACTACAAGCCCAAAAAGTTTGTAAACTCCCAACCGACTCAAACCGTAGATATAGCTGATAAGGAGGAGAATAAGGAGACTATCATTAAGCTGATCGAGGATGTTTTGTGTTCGATCAAGTTGAATGTTGGGGAGGGTAAGGAGAAGAATTCTGAGGATGGGAGTGAAGTGGTGGTGAAAAGTGAAATGATTAGTGAGAACTGTAGTTTGAGTATTTCGGAGAATGTCCCGGAAGCGGAGCCTCCTGGGAAGAAAAAAAGGGGGAGGAAGAGGAAACTGGTTTCGCAGAGCAGTAAGGCTAAAAGGTTGGCTAATAGTGTTGATCCTGGGTATAAGTATCAGTGTGAGAGGTGTGCTAAGGTTTTTGATAGGGTTATGGATTTGGAGGCGCACAGGGATACGGATCATCCTGCTAATTATAAATGTGAAGAATGTGATCAGGTAGTACACAGTTCAAAAGCCCTATTAATTCACAGTAGAGCCCACCAAAGTCTCAAACCATACGTTTGTGAAATATGCAAACGGTGCTATTCACAAACATCCCATTTATGGCAGCACATGCGATTCCATCAAGGTATTAAACCCTTTGCTTGTCCTCACGAGGGCTGCGAAGCAAGGTACACGATACGTCCGGATTTGAAGGACCACATCAGGAAAGTGCACACCAGGGAAAGGCCCTTCAAGTGCTCCGTTTGTTCGAAATGTTTCCTGACGGGTTCTGTTTATTATCAGCATAGGTTGATACATACGAATGATCGAAGATACGCATGTGATATTTGCAACAAGAGATTCTTCAGAGCGGATACGTTAAACAACCACAGAGCGTTTCAATGA
Protein Sequence: MNRDENTAYLRFHRIFPDGSIQSVQLKIDCRTNQVIARMPITSELPPGYDQNFSEEKFNFNYNSLKLNDSSIRVIKLGGVEDLNPLNYASEISTVLNDPIQVKTSPSSSFVSNNQNNNNNANLQKRESKVPNIPTMIRCQNCDTNFPTKYQFQRHQCEFNAEKVVLKPNIDAKDIDKGVRMKFDCPTCGKQFVSKNNLERHLTSHDEDNVNICEFCNKQFVSENRLRIHKENHCKKAGDILKFYRSDVTVWKCVKCYQVFSSDVYACSHSGNCTEILNPEEFQALSLNVVENQDSEVKVDYVEKVLTELLLQCEYCNKTYSDKESLLIHQNTHSTDTNYHCVICMETFESFTLAAKHWLTKCVNEANLFYLPKLTYCSTCERTFKSHEVLYSHKIKKKHYKPKKFVNSQPTQTVDIADKEENKETIIKLIEDVLCSIKLNVGEGKEKNSEDGSEVVVKSEMISENCSLSISENVPEAEPPGKKKRGRKRKLVSQSSKAKRLANSVDPGYKYQCERCAKVFDRVMDLEAHRDTDHPANYKCEECDQVVHSSKALLIHSRAHQSLKPYVCEICKRCYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCSVCSKCFLTGSVYYQHRLIHTNDRRYACDICNKRFFRADTLNNHRAFQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01186477;
90% Identity: iTF_01186477;
80% Identity: -